High Risk Pregnancy Flashcards
A _______ is one in which the fetus is
at increased risk of stillbirth, neonatal morbidity or
death, and/or the expectant mother is at increased
risk for morbidity or mortality
high-risk pregnancy
The WHO definition of maternal mortality is the
death of a woman during ______, _______, __________, irrespective of
duration or site of the pregnancy, from any cause
related to or aggravated by the pregnancy or its
management.
pregnancy, childbirth or
in the 42 days of the puerperium
The ________ is the number of deaths per 100 000 confinements. In first world countries it is approximately 10.
maternal mortality ratio
The latest
triennium statistics for Australia was ____________ confinements—
_______ for non-Indigenous
Australians and 21.5 for ASTI people (c.f. Africa
approx. 900).
8.4 deaths per
100 000
8
The main causes of direct maternal deaths in Australia are (in order)
- amniotic fluid embolism
- thrombosis and thromboembolism
- haemorrhage
- hypertensive disorders of pregnancy
- cardiac conditions
- anaesthetic-associated deaths
Some Australian obstetric statistics for 2003:
- average age of all mothers was _____
- spontaneous vaginal births—______
- caesarean section (CS) rate—______
- instrumental delivery rate—_____
- multiple pregnancies—____
- 5 years
- 3%
- 5%
- 7%
- 7
The_______ is the total number of deaths
of children within 28 days of birth (early neonatal
deaths) plus fetal deaths at a minimum gestation
period of 20 weeks or a minimum fetal weight of 400 g
expressed per 1000 births
perinatal mortality
The major factors associated with perinatal mortality in NSW are 1 2 3
very premature birth, congenital
abnormalities and hypoxia during the antenatal
period or in labour.
A review of perinatal deaths
occurring in 2003 in Australia found that _____
of perinatal deaths (or 45.7% of stillbirths) were
unexplained antepartum deaths
30.9%
The earlier that ultrasound is performed after _______of gestation, the more accurate the determination.
6–7 weeks
Hypertensive disorders complicate about _____ of all
pregnancies
10%
________ which in
fact complicates 2–8% of pregnancies, can occur at
any time in the second half of pregnancy or even just
following delivery
Pre-eclampsia,
What is pregnancy induced HPN
— SBP >140 mmHg and DBP >90 mmHg,
occurring for first time after 20th week of
pregnancy and regressing postpartum
or
— Rise in SBP >25 mmHg or DBP >15 mmHg
from readings before pregnancy or in first
trimester
_____________BP up to 170/110 mmHg in
absence of associated features (
Mild pre-eclampsia.
Severe pre-eclampsia. BP >170/110 mmHg and/or associated features, such as 1 2 3 4 5
kidney impairment, thrombocytopenia, abnormal liver transaminase levels, persistent headache, epigastric tenderness or fetal compromise
____________ Chronic
underlying hypertension occurring before the
onset of pregnancy or persisting postpartum
Essential (coincidental) hypertension.
__________ Underlying
hypertension worsened by pregnancy
Pregnancy-aggravated hypertension.
Test for pre-eclampsia:
1
2
3
spot urinary albumin– creatinine ratio, or 24-hour urinary protein excretion
The following are risk factors for pregnancy-induced
hypertension
- nulliparity/primigravida
- family history of hypertension/pre-eclampsia
- chronic essential hypertension
- diabetes complicating pregnancy
- obesity
- donor sperm or oocyte pregnancy
- multiple pregnancy
- hydatidiform mole
- hydrops fetalis
- hydramnios
- kidney disease
- autoimmune disease (e.g. SLE)
Clinical features of superimposed pre-eclampsia include 1 2 3
hypertension, excessive weight gain,
generalised oedema and proteinuria (urinary protein
>0.3 g/24 hours).
Risks of severe pre-eclampsia/ hypertension
Maternal risks (poor control)
- Kidney failure
- Cerebrovascular accident
- Cardiac failure
- Coagulation failure
Risks of severe pre-eclampsia/ hypertension
Risks to baby
- Hypoxia
- Placental separation
- Premature delivery
In pre-eclampsia
The BP level should be kept below _______
mmHg because at this level intra-uterine fetal death is
likely to occur and there is a risk of maternal stroke
160/100
Contraindicated drugs for pre-eclampsia are
ACE inhibitors and diuretics
Commonly used medications for pre-eclampsia
• beta blockers (e.g. labetalol, oxprenolol and
atenolol) (used under close supervision and after
20 weeks gestation)
• methyldopa: good for sustained BP control
• nifedipine
_____, _______ and _______are useful
for rapid control of BP in hypertensive crises (e.g.
hydralazine 5 mg IV bolus every 20–30 minutes or
continuous infusion).
Labetalol, hydralazine and diazoxide
Guidelines for urgent referral/admission
to hospital
Maternal factors
•Progressing pre-eclampsia including development
of proteinuria
• Inability to control BP
• Deteriorating liver, blood (platelets), kidney
function
• Neurological symptoms and signs
Guidelines for urgent referral/admission
to hospital
Fetal factors
• Abnormal cardiotocograph (CTG) indicating fetal
distress
• Intra-uterine growth retardation
Treatment of severe pre-eclampsia: prevention of convulsions
1
2
3
• Control BP: use IV hydralazine or diazoxide—don’t
suppress to <140/80 as this can induce fetal hypoxia
• Magnesium sulphate 50% 4 g IV (given over
10–15 minutes) followed by an infusion 1 g/hour
for a minimum of 24 hours (if normal kidney
function)
• Corticosteroid therapy IM for fetal lung maturity
if gestation ≤ 34 weeks
What to monitor is severe pre-ecl
Monitor fetus and maternal BP, urine output,
urine protein, coagulation profile
The best treatment for pre-ecl is
termination of pregnancy with early delivery—by CS or vaginal delivery if favourable circumstances
Treatment of convulsion
bolus of 2 g MgSO 4 .
Consider an alternative—IV diazepam or clonazepam
In Mx of eclampsia
- Avoid _____ in the third stage.
- Be prepared for a possible _____
ergometrine
postpartum haemorrhage
What is HELLP syndrome
Haemolysis Elevated Liver enzymes Low Platelets is
a severe form of pre-eclampsia occurring in 20% of
these patients. Treat as for severe pre-eclampsia with
early delivery
Anaemia is defined as a haemoglobin _____.
Levels below this, particularly less than __, require
investigation.
<110 g/L
100 g/L
Important types of anaemia in pregnancy:
1
2
3
• iron deficiency (approximately 50%)
• megaloblastic anaemia (usually due to folic acid
deficiency)
• thalassaemia (most commonly β -thalassaemia
Treatment of anemia according to cause:
— iron deficiency: ______
— megaloblastic anaemia: ______
— thalassaemia: no treatment is possible but
_____
ferrous sulphate 0.9 g (o) daily, iron infusion may be required
folic acid 5 mg (o) bd
partner also needs to be screened
Fetal effects of DM
Large for dates (macrosomia), fetal abnormalities
(neural tube, cardiac, kidney, vertebral, etc.
defects), hypoxia and intra-uterine death (IUFD),
miscarriage, malpresentation, IUGR, preterm
delivery
Postnatal effects on fetus of DM
Early hypoglycaemia, respiratory distress
syndrome, jaundice
Effects on the mother of DM
Increased risk of pre-eclampsia, diabetic
ketoacidosis, polyhydramnios, intercurrent
infection, psychological effects, first trimester
miscarriage, obstructed labour (shoulder
dystocia), placental abruption, CS
Aim for diabetic control:
FBS and Hba1c
fasting blood sugar 4–7
mmol/L: HbA1c <7%
When to do fetal morphology tests in DM mothers
• Screen for fetal morphology and growth:
ultrasound at 18 weeks then 4 weekly and as
required; cardiotocography as required—usually
weekly from 32–34 weeks until delivery
Aim to deliver in DM mothers at term at latest:
— vaginally if optimal control
— CS if __________
large fetus (>90th weight percentile
or >4000 g) or evidence of fetal distress or
breech presentation
In DM, postpartum care involves:
Cease insulin infusion and ↓ insulin to
pre-pregnancy regimen immediately after
delivery; organise contraception; avoid oral
hypoglycaemics during breastfeeding
Gestational diabetes is the onset or initial recognition
of abnormal glucose tolerance during pregnancy. If
suspected a diagnostic________
oral glucose (75 g) tolerance test is indicated.
GDM
Diagnosis: fasting blood glucose ______
or
2-hour level______
> 5.5 mmol/L
> 8.5 mmol/L
_______ in pregnancy is unhelpful for
screening because it is common in pregnancy and
lacks specificity
Glycosuria
On GDM
Follow up GTT at 6 weeks and then every
5 years. Gestational diabetes is likely in subsequent
pregnancies and there is a ______ risk of developing
diabetes in later life—even <10 years
30%
_______ in pregnancy is uncommon and
usually mild. It is associated with infertility. It is
associated with a higher rate of fetal loss, miscarriage,
fetal abnormalities and IUGR
Hypothyroidism
When to do testing for TFT
TFTs should be checked at first presentation if past history is relevant and at 36 weeks
_______ is usually the preferred agent in Graves in pregnancy
Propylthiouracil
The highest risk of maternal mortality during pregancy is where
pulmonary blood flow cannot be increased
(e.g. pulmonary hypertension, Eisenmenger
syndrome
______ and _______ may be a pointer to a
cardiac disorder
Syncope and dyspnoea
________is important for those
with structural cardiac problems (e.g. valvular
problems), most congenital malformations
Antibiotic prophylaxis
Patients with an increased risk of bacterial
endocarditis (especially with rheumatic heart
disease) require an antibiotic cover in labour of
______ and _______
penicillin and gentamicin
What to avoid in Cardiac do
As a rule avoid lithotomy, ergometrine,
sympathomimetic drugs
Crea level with increased CX
↑ maternal and fetal complications in moderate
failure (s. creatinine 0.125–0.25 mmol/L) and
severe kidney failure (>0.25 mmol/L).
T or F
Pregnancy does not seem to cause exacerbations
of SLE.
T
SLE in pregnancy
Increased incidence of spontaneous abortions
and stillbirths—related to_____ and ______
lupus anticoagulant
and anticardiolipin antibodies