Abdominal pain Flashcards

1
Q

An international study involving referral to 26
surgical departments in 17 countries revealed nonspecific
1
2
3
the most common conditions.

A
abdominal pain (34%),
 acute appendicitis (28%) 
and cholecystitis (10%)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T or F

As a general rule, upper abdominal pain is caused
by lesions of the upper GIT and lower abdominal
pain by lesions of the lower GIT

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Colicky midline umbilical abdominal pain

(severe) → vomiting → distension = ______

A

small bowel

obstruction (SBO).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Midline lower abdominal pain → distension →

vomiting = _______

A

large bowel obstruction (LBO).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

If cases of acute abdomen have a surgical cause,

the pain nearly always precedes the _____

A

vomiting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

________ must be considered in
an elderly person with arteriosclerotic disease or
in patients with atrial fibrillation presenting with
severe abdominal pain or following myocardial
infarction

A

Mesenteric artery occlusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Up to ________of presentations of abdominal pain
are considered to be non-specific, whereby no
specific cause is found

A

one-third

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q
A study on chronic abdominal pain 4 showed that the
commonest reasons (approximate percentages) were
A
no discoverable causes (50%), 
minor causes including muscle strains (16%),
 irritable bowel syndrome (12%), 
gynaecological causes (8%), 
peptic ulcers and hiatus hernia (8%).
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Red flag pointers for acute abdominal pain

History
1
2
3
4
5
6
A
  1. Collapse at toilet
  2. Lightheadedness
  3. Ischaemic heart disease
  4. Progressive-vomiting pain, distension
  5. Menstrual abnormalities
  6. Malignancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Red flag pointers for acute abdominal pain

Signs
1
2
3
4
5
6
A
  1. Hypotension
  2. Atrial fibrillation or tachycardia
  3. Fever
  4. Prostration
  5. Rebound tenderness and guarding
  6. Decreased urine output
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q
Dangers of misdiagnosis
• \_\_\_\_\_\_\_\_ → rapid hypovolaemic shock
• \_\_\_\_\_\_\_\_ → rapid hypovolaemic shock
• \_\_\_\_\_\_\_\_ → peritonitis/pelvic abscess
• \_\_\_\_\_\_\_\_ → peritonitis
• \_\_\_\_\_\_\_\_ → gangrene
A
Ectopic pregnancy
Ruptured AAA
Gangrenous appendix
Perforated ulcer
Obstructed bowel
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Early appendicitis
presents typically with ___________some 4 to 6
hours later.

A

central abdominal pain

that shifts to the right iliac fossa (RIF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Disaccharidase deficiencies, such as _______ are associated with cramping abdominal pain,
which may be severe

A

lactase

deficiency,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Specific pitfalls in the dx

Failing to examine _______ in a patient
with intestinal obstruction

A

hernial orifices

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Misleading temporary improvement (easing of

pain) in _____ or ______

A

perforation of gangrenous appendix or

perforated peptic ulcer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Spinal dysfunction of the _____ or _______ can cause referred pain
to the abdomen

A

lower thoracic spine

and thoracolumbar junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

________ can be most relevant, especially
in recurrent or chronic abdominal pain where no
specific cause can be identified in most cases.

A

Psychogenic factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

_______ is hospital admission by
deception, often with severe abdominal pain without
convincing clinical signs or abnormal investigation

A

Munchausen syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

special clinical tests for abdominal pain:

_______ (a sign of peritoneal tenderness with acute cholecystitis); iliopsoas and obturator signs

A

Murphy sign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

_______ occur through
defects in transversus abdominal muscle lateral
to the rectus sheath—usually below the level of
the umbilicus

A

Spigelian hernias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

PE:

Palpation: palpate with gentleness—note any
guarding or rebound tenderness: guarding
indicates _______

rebound tenderness indicates _____ (bacterial peritonitis, blood)

A

peritonitis;

peritoneal irritation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Patient pain indicator:

the ______indicates focal peritoneal irritation;

the_______indicates visceral pain

A

finger pointing sign

spread palm sign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Atrial fibrillation: consider ____

A

mesenteric artery

obstruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q
  • ______ sepsis and volume depletion
  • _______: sepsis, pneumonia, acidosis
  • Pallor and ‘shock’: _______
A

Tachycardia:
Tachypnoea
acute blood loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Auscultation: note bowel activity or a_______ (best before palpation and percussion)
succussion | splash
26
Causes of a ‘silent abdomen’: 1 2 3
``` diffuse sepsis, ileus, mechanical obstruction (advanced ```
27
Hypertympany indicates _____
mechanical obstruction
28
_______if raised to greater than three times normal upper level acute pancreatitis is most likely
serum amylase and/or lipase (preferable
29
What can you see in a plain abdominal xray ``` — _______—70% opaque — _______—only 10–30% opaque — air in biliary tree — calcified aortic aneurysm — marked distension sigmoid →_____ — distended bowel with fluid level → __________ — enlarged caecum with large bowel obstruction — blurred right psoas shadow →_______ ```
kidney/ureteric stones biliary stones sigmoid volvulus bowel obstruction appendicitis
30
What can you see in a plain abdominal xray sentinel loop of gas in left upper quadrant (LUQ) → _________
acute pancreatitis
31
chest X-ray: air under diaphragm → _______
perforated ulcer
32
Dxtics ________ good for hepatobiliary system, kidneys and female pelvis
ultrasound:
33
T or F UTZ can be affected by shadows
T
34
_________—diagnosis of acute | cholecystitis
HIDA or DIDA nuclear scan
35
__________: gives excellent survey of abdominal | organs including masses and fluid collection
CT scan
36
________: shows bile duct obstruction and pancreatic | disease
ERCP
37
______ is a rhythmic pain with regular spasms of recurring pain building to a climax and fading. It is virtually pathognomonic of_____
Colicky pain intestinal obstruction
38
______ is a true colicky abdominal pain, but so-called biliary colic and kidney colic are not true colics at all
Ureteric colic
39
________ usually arises from disorders of the embryologic foregut, such as the oesophagus, stomach and duodenum, hepatobiliary structures, pancreas and spleen
Epigastric pain
40
_______ usually arises from disorders of structures of | the embryologic midgut
Periumbilical | pain
41
structures from the _______ tend to refer pain to the lower abdomen or suprapubic region
hindgut
42
The intra-abdominal sensory receptors can be considered as innervating______ or ________ peritoneum.
visceral or parietal
43
Visceral _________ are triggered by intestinal distension or tension on mesentery or blood vessels while _______ are triggered by mechanical, thermal and chemical stimuli
mechanoreceptors nociceptors
44
The pain from viscera is felt as __________localised while stimulation of parietal peritoneal nociceptors gives a pain that is experienced directly at the site of insult.
diffuse and poorly
45
Acute abdominal pain in children Common causes/probability diagnosis: 1 2 3
* infant colic * gastroenteritis (all ages) * mesenteric adenitis
46
Acute abdominal pain in children Serious causes, not to be missed: * ________ (peaks at 6–9 months) * ________ (mainly 5–15 years) * bowel obstruction
intussusception acute appendicitis
47
Acute abdominal pain in children: ``` Rarities: 1 2 3 4 ```
* Meckel diverticulitis * Henoch–Schönlein purpura * sickle crisis * lead poisoning
48
This is the occurrence in a well baby of regular, unexplained periods of inconsolable crying and fretfulness, usually in the late afternoon and evening, especially between 2 weeks and 16 weeks of a
Infant ‘colic’ (period of infant distress)
49
Infant ‘colic’ (period of infant distress) Crying worst at around ______ weeks of age
10
50
Infant ‘colic’ (period of infant distress) Drugs are not generally recommended, but for very severe problems some preparations can be very helpful (e.g. _________
simethicone
51
__________is the diagnosis that should be foremost in one’s mind with a child aged between 3 months and 2 years presenting with sudden onset of severe colicky abdominal pain, coming at intervals of about 15 minutes and lasting for 2–3 minutes
Intussusception
52
What is the pathophysiology of Intussusception?
``` It is due to the telescoping of a segment of bowel into the adjoining distal segment (e.g. ileocaecal segment), resulting in intestinal obstruction. ```
53
What is the cause of Intussusception?
It is usually idiopathic but can have a pathological lead point (4–12 years) (e.g. polyp, Meckel diverticulum)
54
Sign of Intussusception?
Sausage-shaped mass in right upper quadrant (RUQ) anywhere between the line of colon and umbilicus, especially during attacks (difficult to feel)
55
Signs of Intussusception • _________ (i.e. emptiness in RIF to palpation) • Alternating high-pitched active bowel sounds with absent sounds • Rectal examination: _______
Signe de dance ± blood
56
Diagnosis of Intussusception • Ultrasound •___________ (with caution) also used for diagnosis and treatment
Oxygen or barium enema
57
Treatment of Intussusception • _______ by air or oxygen from the ‘wall’ supply (preferred) or barium enema • Surgical intervention may be necessary
Hydrostatic reduction
58
In any child complaining of acute abdominal pain, | enquiry should be made into ______
drug ingestion
59
A common cause of colicky abdominal pain in children | is _______
cigarette smoking (nicotine)
60
AA in children This may occur at any age, being more common in children of_________ and in adolescence, and uncommon in children under 3 years of age
school age (10–12 years)
61
A serious point of confusion can occur between ________, causing diarrhoea and vomiting, and acute gastroenteritis
pelvic | appendicitis
62
This presents a difficult problem in differential diagnosis with acute appendicitis because the history can be very similar. At times the distinction may be almost impossible
Mesenteric adenitis
63
T or F with mesenteric adenitis localisation of pain and tenderness is definite, rigidity is less of a feature, the temperature is higher, and anorexia, nausea and vomiting are also lesser features
F pain and tenderness not as definite
64
Mesenteric adenitis can sometimes present an anaesthetic risk and patients are usually quite ill in the immediate _______ period. Treatment is symptomatic and includes ample fluids and paracetamol.
postoperative
65
__________—three distinct episodes of abdominal pain over 3 or more months— occurs in 10% of school-aged children
Recurrent abdominal pain (RAP)
66
How many percent of RAP can organic cause be found?
In only 5–10% | of children will an organic cause be found
67
Possible causes of RAP ``` • Constipation •_________ (pain with extreme pallor) •_________ (symptoms related to milk ingestion) • _________ (may disturb child about 60 minutes after falling asleep) ```
Childhood migraine equivalent Lactose intolerance Intestinal parasites
68
Non-organic RAP Clinical features * __________ abdominal pain * pain localised to or just above_______
acute and frequent colicky umbilicus
69
Non-organic RAP * no radiation of pain * pain lasts less than _____ * nausea frequent and vomiting rare
60 minutes
70
Non-organic RAP ``` • ______(never wakes the child at night) • minimal umbilical tenderness • anxious child • __________ personality • one or both parents intense about child’s health and progress ```
diurnal obsessive or perfectionist
71
Psychogenic factors Some children will have obvious psychological problems or even be school avoidant, a common factor being ______
family disruption
72
Abdominal pain in the elderly Problems arise with management because the ________ and there is _________so that fever and leucocytosis can be absent
pain threshold is raised (colic in particular is less severe) an attenuated response to infection
73
An ______ may be asymptomatic until it ruptures or may present with abdominal discomfort and a pulsatile mass noted by the patient
AAA
74
AAA _______ is advisable in first-degree relatives over 50 years
Ultrasound screening
75
The normal diameter of the abdominal aorta, which is palpated just above the umbilicus, is 10–30 mm, being 20 mm on average in the adult; an aneurysm is greater than _____ in diameter.
30 mm
76
Greater than _____ is significantly enlarged and is chosen as the arbitrary reference point to operate because of the exponential rise in risk of rupture with an increasing diameter
50 mm
77
AAA TX The patency of a _____after 5 years is approximately 95% (
Dacron graft
78
AAA Investigations • ______ (good for screening) in relatives >50 years (obesity a problem) • CT scan (clearer imaging). ________ scan is investigation of choice. • MRI scan (best definition)
Ultrasound Helical/spiral
79
This is a real surgical emergency in an elderly person who presents with acute abdominal and perhaps back pain with associated circulatory collapse
Rupture of aneurysm
80
intense pain + pale and ‘shocked ± | back pain ______
ruptured AAA
81
Acute intestinal ischaemia arises from ________occlusion from either an embolus or a thrombosis in an atherosclerotic artery
superior mesenteric artery
82
Clinical features of aute mesenteric ischemia 1 2 3 4
• Abdominal pain—gradually becomes intense (see FIG. 34.7 ) • Profuse vomiting • Watery diarrhoea—blood in one-third of patients (later) (refer CHAPTER 44) • Patient becomes confused
83
``` Signs of aute mesenteric ischemia 1 2 3 4 ```
• Localised tenderness, rigidity and rebound over infarcted bowel (later finding) • Absent bowel sounds (later) • Shock develops later • Tachycardia (may be atrial fibrillation and other signs of atheroma
84
Dx of aute mesenteric ischemia. X-ray (plain) shows _____ due to mucosal oedema on gas-filled bowel. _______ gives the best definition while ______ is performed if embolus is suspected. However, it is commonly only diagnosed at______
‘thumb printing’ CT scanning mesenteric arteriography laparotomy
85
Management of aute mesenteric ischemia. Early surgery may prevent gut necrosis but massive ______may be required as a lifesaving procedure.
resection of necrosed gut
86
In pts with mesenteric ischemia: • _______ can occur but usually in patients with circulatory failure. • _________ occlusion is less severe and survival more likely
Mesenteric venous thrombosis Inferior mesenteric artery
87
_______ usually causes severe lower abdominal pain, which may not be apparent in a senile or demented person.
Acute retention of urine
88
Causes of Acute retention of urine 1. 2 3
enlarged prostate or prostatitis bladder neck obstruction by faecal loading or other pelvic masses or anticholinergic drugs
89
Mx of Acute retention of urine • Perform a _______and empty rectum of any impacted faecal material. • _________to relieve obstruction and drain (give antibiotic cover). • Have the catheter in situ and seek a urological opinion. Send specimen for MCU.
rectal examination Catheterise with size 14 Foley catheter
90
_____ is encountered typically in the aged, bedridden, debilitated patient. It may closely resemble malignant obstruction in its clinical presentation. Spurious diarrhoea can occur, which is known as _____
Faecal impaction ‘faecal incontinence’
91
localised RIF pain + a/n/v + guarding
acute appendicitis
92
AA signs pain on resisted flexion of right leg, on hip extension or on elevating right leg (due to irritation of psoas especially with retrocaecal appendix)
± Psoas sign:
93
AA signs _________pain on flexing patient’s right thigh at the hip with the knee bent and then internally rotating the hip (due to irritation of internal obturator muscle)
± Obturator sign:
94
AA signs _______ tenderness in RIF while palpating in LIF
Rovsing sign:
95
Variations and cautions in AA • _________ → localised mass and tenderness • _________: pain and rigidity less and may be no rebound tenderness; loin tenderness; positive psoas test • _________: no abdominal rigidity; urinary frequency; diarrhoea and tenesmus; very tender PR; obturator tests usually positive
Abscess formation Retrocaecal appendix Pelvic appendix
96
Variations and cautions in AA • ________: pain often minimal and eventually manifests as peritonitis; can simulate intestinal obstruction • Pregnancy (occurs mainly during second trimester): pain is higher and more lateral; harder to diagnose; peritonitis more common • Perforation more likely in the ____, ________, ______
Elderly patients very young, the aged and the diabetic
97
AA plain X-ray findings
may show local distension, blurred | psoas shadow and fluid level in caecum
98
Management of AA Immediate referral for surgical removal. If perforated, cover with ____ or _______
cefotaxime and metronidazole
99
SBO The more _____ the obstruction, the more severe the pain.
proximal
100
colicky central pain + vomiting + | distension
SBO
101
Signs of SBO ``` • Patient weak and _____ • Visible peristalsis,______ • Abdomen soft (except with _____) • Tender when distended • Increased sharp, tinkling bowel sounds • Dehydration rapidly follows, especially in children and elderly ```
sitting forward in distress loud borborygmi strangulation
102
LBO The cause is commonly________r (75% of cases), especially on the left side, but it can occur in ______ or _______ of the sigmoid colon (10% of cases) and caecum
colon cancer diverticulitis or in volvulus
103
LBO _____is more common in older men and has a sudden and severe onset. The pain is less severe than in SBO
Sigmoid volvulus
104
ddx of LBO pseudo-obstruction of the colon or ______
(Ogilvie syndrome
105
Clinical features of LBO * __________ pain (even with cancer) * Each spasm lasts less than 1 minute * Usually hypogastric midline pain (see FIG. 34.11 ) * Vomiting may be absent (or late) * Constipation, no flatus
Sudden-onset colick
106
colicky pain + distension ± vomiting
LBO
107
X-ray of LBO: distension of large bowel with separation of haustral markings, especially caecal distension — sigmoid volvulus shows a ______ — ________ confirms diagnosis
distended loop gastrografin enema
108
T or F perforated duodenal ulcer is more common than a gastric ulcer
T
109
3 stages of perforated peptic ulcer 1 2 3
``` 1 prostration 2 reaction (after 2–6 hours)—symptoms improve 3 peritonitis (after 6–12 hours ```
110
sudden severe pain + anxious, still, | ‘grey’, sweaty + deceptive improvement
perforated peptic ulcer
111
presents as severe true colicky pain due to stone movement and ureteric spasm
ureteric colic
112
________is not a true colic but a constant pain due to blood clots or a stone lodged at the pelvic– ureteric junction
Kidney renal colic
113
Features of ureteral colic * _____—stone in kidney * ______—ureteric stone * ______—stone in bladder
loin pain kidney/ureteric colic strangury
114
Clinical features of ureteral colic • Maximum incidence ______ years (M > F) • Intense _____: in waves, each lasting 30 seconds with 1–2 minutes respite • Begins in_______ (see FIG. 34.13 ) * Usually lasts <8 hours * ± Vomiting
30–50 colicky pain loin and radiates around the flank to the groin, thigh, testicle or labia
115
Dxtics of ureteral colic ______microscopy; blood testing strip (negative does not exclude calculus) • Plain X-ray: most stones—kidney, ureter, bladder (75%)—are ______ (calcium oxalate and phosphate) ________ confirms opacity, level of obstruction, kidney function and any anatomical abnormalities
Urine: radio-opaque • IVP:
116
Dxtics of ureteral colic • Ultrasound: may locate calculus but will exclude obstruction • ________ is the ‘gold standard’ (sensitivity 97%, specificity 96%) (will show easily missed radiolucent 11 uric acid stones
Non-contrast spiral CT
117
In ureteral colic: Further pain can be alleviated by __________ but should be limited to two a day.
indomethacin | suppositories
118
The calculus is likely to pass spontaneously if | ______ (90%) <4 mm pass spontaneously
<5 mm
119
If calculus ______ intervention will usually be required by extracorporeal shock wave lithotripsy or surgery
>5 mm
120
A repeat IVP may be necessary if there is evidence | of obstruction for more than _____
3 weeks
121
Facts about urinary tract calculi • The prevalence is _______ population per year • The lifelong incidence is _____ • The recurrence is up to ______ (most within 2 years) • The typical age range is 20 to 50 years (peaks at 28 years)
1 to 3 per 1000 10% 75%
122
Some patients who present with typical colic may be feigning their pain mainly because they are opioid dependent and seeking drugs by deception. What is this called?
Phony colic
123
the stereotyped patient is female, 40, fat, fair and fertile it can occur from adolescence to old age and in both sexes
Biliary pain
124
Features of Biliary pain * acute onset severe pain * _______or at night (often wakes 2–3 am) * constant pain (not colicky) * lasts 20 minutes to 2–6 hours * maximal______
post-prandial RUQ or epigastrium
125
Biliary pain: • may radiate to ____ • painful episode builds to a crescendo for about 20 minutes; may recede or last for hours • some relief by assuming_________ • ± nausea and vomiting with considerable retching • often a history of biliary pain (may be mild) or jaundice
tip of right shoulder or scapula flexed posture
126
Signs of Biliary colic ``` • Patient anxious and restless, usually in a flexed position or rolling in agony • Localised tenderness_______over fundus of gall bladder (on transpyloric plane) • Slight rigidity ```
(Murphy sign)
127
Diagnosis of biliary obstruction ``` • Abdominal ultrasound/DIDA • Helical CT • _________ if previous cholecystectomy • LFTs may show elevated ____ and _____ ```
Intravenous cholangiography bilirubin and alkaline phosphatase
128
Tx of biliary obstruction • Gallstone dissolution or _______ (in those unable to have surgery) • ____________ (main procedure)
lithotripsy Cholecystectomy
129
Types of gallstones:
Two main types—cholesterol and pigment | bilirubin
130
70% of people with gall bladder stones are asymptomatic, but risk of developing symptoms is about _____ over 20 years
15%
131
______ is associated with gallstones in over 90% of cases and there is usually a past history of biliary pain. It
Cholecystitis
132
The causative | organisms of acute cholecystitis are usually aerobic bowel flora (e.g. _____ and _____
E. coli, | Klebsiella species and Enterococcus faecalis).
133
With acute pancreatitis there may be a past history of ________ or a past history of ______ (35%) or gallstone disease (40–50%).
previous attacks alcoholism
134
severe pain + nausea and vomiting | + relative lack of abdominal signs
acute | pancreatitis
135
acute pancreatitis dx ``` WCC—______ • Serum _________ (preferred as more sensitive and specific) or serum amylase • CRP—elevated • Serum glucose ↑, calcium ↓ ```
leucocytosis
136
In comparison to acute pancreatitis, the pain of | chronic pancreatitis is _______
milder but more persistent.
137
____ and _______may result from pancreatitis and weight loss and steatorrhoea become prominent features
Malabsorption and diabetes
138
Pain associated with _________ is indistinguishable from that of chronic pancreatitis but generally tends to be more severe and more prominent in the back
pancreatic cancer
139
Chronic Panc Give pancreatic enzyme supplements (e.g. pancrelipase) for________
steatorrhoea
140
The patient with __________ is usually over 40 years of age, with long-standing, grumbling, leftsided abdominal pain and constipation, but can have irregular bowel habit
acute diverticulitis
141
Typical clinical features of acute diverticulitis are: * acute onset of pain in the_________ * pain increased with walking and ______ * usually associated with constipation
left iliac fossa change of position
142
Can be generalised due to intra-abdominal sepsis following perforation of a viscus e.g. peptic ulcer, appendix, diverticulum
Peritonitis
143
abx for peritonitis
Usual antibiotic treatment is IV cephalosporins or amoxy/ampicillin + gentamicin + metronidazole. 1
144
Spontaneous bacterial | peritonitis can occur in any patient with _______
ascites.
145
What to do in abdominal stitch
• stop and rest, then walk—don’t run • apply deep massage to the area with the palps (fleshy tips) of the middle three fingers • perform slow or deep breathing
146
___________—this may allow the identification of chronic adhesive obstruction, small bowel tumours or inflammation, or intra-abdominal malignancy
laparoscopy
147
T or F It is possible to have recurrent episodes of subacute inflammation of the appendi
t