Hepato cellular Cancer

Question 1

LIRADS

Answer 1

Liver imaging reporting and data systems

Question 2

LIRADS classification

Answer 2

LR 1 - 100% benign
LR 2- probably benign
LR 3- intermidiate possibility of HCC
LR 4- Probably HCC
LR 5 - 100% HCC

Question 3

Most common primary malignant tumour of liver

Answer 3

HCC

Question 4

Risk factors for HCC

Answer 4

Hepatitis B (Earlier) reduction after vaccine
Hepatitis C (17% increase)
Diabetes mellitus
Obesity alcohol
Cirrhosis of liver
Alpha-1- antitrypsin deficiency
Haemochromotosis
Wilsons disease
Thorotrast exposure

Question 5

Thorotrast exposure increases the risk of

Answer 5

HCC
Cholangiocarcinoma
RCC

Question 6

Vinyl chorise increase the risk of

Answer 6

Angiosarcoma

Question 7

CF of HCC

Answer 7

Male
Hepatomegaly ( early presentation)
Abdominal pain
Jaundice (late sign)
Paraneoplastic sx

Question 8

Paraneoplastic sx associated with HCC are

Answer 8

Hypoglycemia(mc)
Biochemical hyperlipidemia (mc)
Gynecomastia
Hypercalcemia

Question 9

IOC of HCC

Answer 9

Triple phase CT

Question 10

Triple ohade CT in HCC shows

Answer 10

Diffrentiates HCC from metastasis

Question 11

Three phases in triple phase CT

Answer 11

Non contrast (both hypodense)
Arterial(HCC hypodense)
Washout/venous( HCC hyperdense)

Question 12

Doubt of HCC can be confirmed by

Answer 12

Tru-cut biopsy

Question 13

Staging of HCC is done by

Answer 13

PET-CT

Question 14

Tumour markers of HCC

Answer 14

Alpha feto protein
Pivka -2 ( protein Induced in vit k antagonism) (des gamma carboxy prothrombin)
Glycipan
HEP PAR-1
Neurotensin-B

Question 15

Fibrosvasular variant in HCC the tumour marker isl

Answer 15

Neurotensin-B

Question 16

The HCC response to therapy is monitered by

Answer 16

Alpha-feto protein(AFP)