Chemotherapy Of Breast Cancer

Question 1

Indications

Answer 1

Positive lymphnode
Locally advanced
ER, PR negative HER 2NEU+ve
>1cm in size

Question 2

If the person is HER2NEU positive along with chemo which is given

Answer 2

Trastuzab(Herceptin)

Targeted therapy

Question 3

Traditional chemo cycles

Answer 3

CAF 6 cycles
(Cyclophospamide, adriamycin, 5-FU)

CMF
(methotrexate)

Question 4

Side effect of cyclophospamide

Answer 4

Hemorrhagic cystitis

Question 5

What is the metabolite which causes hemorrhagic cystitis

Answer 5

Acrolein

Question 6

Prevent agent in hemorrhagic cystitis

Answer 6

MESNA

Question 7

Side affect of adriamyocin

Answer 7

Dilated cardiomyopathy

Question 8

5-FU side effect

Answer 8

Bone marrow suppression

Question 9

Nowadays given chemo

Answer 9

4 cycles AC(Adriamycin, cyclophospamide)

Followed by 4 cycles of
Paclitaxel Or docxetaxel

Question 10

Paclitaxil can cause

Answer 10

Neuropathy

Question 11

If HER2NEU positive

Answer 11

Herceptin Or transtuxumab

(SE- cardiotoxicity)

Question 12

Avoid chemo in breast cancers

Answer 12

Poor performance status(kornofsky/ECOG)
>70 Years of age
T1 T2 N0 M0 ER PR +-ve HER2NEU -ve
Early stages molecular test done

Question 13

Should a triple negative person be given chemo

Answer 13

Yes

Question 14

Names of molecular test

Answer 14

Oncotype Dx(21 gene assay, only ER, PR +ve)

Mammaprint (70 gene assay ER, PR +ve Or negative)

Endopredict(12 gene)

Pam 50 (50 gene assay)

Question 15

Molecular test is done to know

Answer 15

Recurrence score

Question 16

Recurrence score developed in india

Answer 16

Canassist

Question 17

Device through which chemotherapy is given

Answer 17

Chemoport