Breast Cancer Flashcards
Prevalence of br cancer
1 in 21 women in India
1 in 8 women (2025)
Risk factors for breast cancer( hormone driver cancer)
Age
Early menarche
Late menopause
Family history (both maternal and paternal)
Obesity
Alcohol consumption
Smoking (premenopausal br cancer)
Hormone replacement therapy (HRT)
E+P
Low dose OCP don’t increase risk
Nulliparity
Maternal age at first live birth <=20 yrs protective
>30 yrs slightly
Atleast 1 year breast feeding
Sporadic breast cancer
90%
Most common gene mutated in familial breast cancer
BRCA 1
Gene mutated in sporiadic br cancer
P53 mutation
BRCA 1 and BRCA 2 increase risk of Ccancers
Breast
Ovarian colorectal
Primary colorectal
Male br cancer
Prostate cancer
BRCA 2>BRCA 1
Pancreatic
Male br cancer
Prostate cancer
Most common hiatology of BRCA 1 tumours
Medullary carcinoma
Basal subtype br tumour
BRCA 1
Luminal subtype br cancer
BRCA 2
HBOC SX 1st degree relative scanned for
BRCA gene mutation
Lifestyle changes in BRCA mutation
Wt reduction
Regular exercise
No smoking and alcohol
MRI Screening
Risk reduction in BRCA Mutation
Prophylactic mastectomy (95%)
Bilateral salphingo oopherectomy(90%)
SERM(tampxifen) (47%)
Most common quadrant affected in breast cancer
Upper outer quadrant
Least common quadrant affected by breast cancer
Lower inner quadrant
