Hemorragia e Trombose

Question 1

Qual a causa de defeito da atividade coagulante plaquetária?

Answer 1

Síndrome de Scott.

Question 2

Fatores de risco para trombose venosa?

Answer 2

Venous
Inherited:
Factor V Leiden 
Prothrombin G20210A 
Antithrombin deficiency 
Protein C deficiency 
Protein S deficiency 
Elevated factor VIII 

Acquired:
Age 
Previous thrombosis 
Immobilization 
Major surgery 
Pregnancy and puerperium 
Hospitalization 
Obesity 
Infection 
APC resistance, nongenetic 
Smoking 

Unknown:
Elevated factor II, IX, XI
Elevated TAFI levels
Low levels of TFPI

Question 3

Fatores de risco para trombose venosa e arterial?

Answer 3

Venous and Arterial
Inherited:
Homocystinuria
Dysfibrinogenemia

Mixed (inherited and acquired):
Hyperhomocysteinemia

Acquired:
Malignancy 
Antiphospholipid antibody syndrome 
Hormonal therapy 
Polycythemia vera 
Essential thrombocythemia 
Paroxysmal nocturnal hemoglobinuria 
Thrombotic thrombocytopenic purpura 
Heparin-induced thrombocytopenia 
Disseminated intravascular coagulation

Question 4

Qual o fator que é exclusivamente avaliado pelo TP?

Answer 4

Fator VII.

Question 5

Fatores avaliados pelo TP?

Answer 5

I, II, V, VII, X.

Question 6

Causas de aumento do tempo de trombina e tempo de reptilase?

Answer 6

Prolongados se:

1. Fibrinogénio baixo (<80-100mg/dL),
2. Fibrinogénio qualitativamente aN (disfibrinogenemias),
3. Quando há interferência dos produtos de degradação do fibrinogénio/fibrina (PDFs).