Heme Onc Flashcards
1 hour after transfusion
fever, flank pain, hemoglobinuria
ABO mismatch
SOB 6 hours after transfusion
TRALI
fever, chills, malaise 4 hours after transfucion
febrile nonhemolytic rxn
leuks release cytokines in donor blood
What does warfarin inhibit
vit k factors:
2 7 9 10 C S
How does heparin work
activates antithrombin 3–>
inhibits
2a, 9a, 10a
How does clopidogrel work?
blocks adenosine diphophate –> prevents plt activiation
Bernard soulier syndrome
- AR
- missing plt glycoprotein Ib-IX-V (vwf receptor)
- bleeding out of proportion vs mild thrombocytopenia
Aplastic crisis
acute severe anemia in SCD
sudden drop in hgb and retic count
NO heptosplenomegally
usually from parvo b19
Aplastic anemia
pancytopenia
hypoplastic fat filled marrow
Can you use MSV to help guide spherocytosis ddx
NO
these fucks are all over the map
What is the very last step of coag cascade (the thing actually making clot)
Fibrinogen –(thrombin)–> fibrin
when do you use thrombolytics in DVT
if iliofemoral involvement
What prevents IgA anaphyaxisis vs blood?
washing the red cells
most common cause of b12 deficiency
prenicious anemia
also has double risk of gastric ca
Thrombotic thrombocytopenic purpura rx
emergent plasma exchange
what is in cryoprecipitate
clotting factor
fibrinogen
vwf
usually used in DIC
Acute chest syndrome
SCD
pulm vasooclusion
fever, CP
problem in paroxysmal nocturnal hemoglobinuria
absent CD55 sets off complememnt cascade –> cell destruction
Side effects of EPO
worsening HTN**
HA**
Flu like s/s**
high yeild
deferoxamine
iron chelator
Imatinib is?
tyrosine kinase inhibitor
key therapy for CML
Choice of med for chemo NV
serotonin antagonost
All trans retenoic acid receptor treats?
APML
subtype of AML
Methotrexate moa?
alters folic acid metabolism
Scopolamine
anti-cholinergic
motion sickness rx
metoclopramide
Da antagonist
used in NV
