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USMLE > Heme Onc > Flashcards

Heme Onc Flashcards

1
Q

hereditary spherocytosis in new born

A

macrocytic

jaundice, splenomegally, spherocytes

ddx w/ RBC fragility test w/ glycerol lysis

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2
Q

Rx for child with ITP

A

No active bleeding= observation- most resolve 6 mo w/ no rx

bleeding: IVIG/ steroidsw

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3
Q

Hereditary angioedema s/s

A

C1 esterase deficiency

edema everywhere
ab pain from intestine edema
NO urticaria

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4
Q

Leukemoid rxn

A

WBC > 50,000 IN RESPONSE TO SEVERE INFECTION

HIGH ALK PHOS (vs CML will not have this)

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5
Q

major toxicity of mycophenolate

A

immunosupressent

bone marrow supression

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6
Q

examples of type 4 hypersensativity

A

tb skin test

allergic contact dermatitis

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7
Q

aquied angioedema

A

low C1q

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8
Q

SCID

A

absent t cells
dysfxn b cells
rx: stem cell transplant

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9
Q

CVID vs bruton

A

CVID presents later in life and is less severe

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10
Q

major toxcity of azathioprine

A

immunosupressant

diarrhea
leukopenia
hepatotoxic

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11
Q

etidronate is?

A

bisphosphonate

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12
Q

can you trust the g6pd assay

A

not really

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13
Q

CGD defect

A

NADPH oxidase

cant kill cat + bugs

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14
Q

most common side effect of cyclosporin

A

nephrotoxicity

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15
Q

DIC labs

A
  • thrombocytopenia
  • prolonged PT and aPTT
  • low fibrinogen
  • schistocytes
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16
Q

s/s of thrombotic throbocytopenic purpura

A

thrombocytopenia
hemolytic anemia
fever
neuro (ams)

17
Q

Pyruvate kinase deficiency

A

chronic hemolysis
big liver/spleen
skin ulcers
pigmented galstones

18
Q

Cancers most likely to raise AFP

A

testicular

liver

19
Q

What causes elevation of homocystine

A

folate or b12 deficiency

20
Q

Haptoglobin is decreased in?

A

hemoytic anemia

21
Q

Most common cause of isolasted thrombocytopenia

A

ITP

IgG vs plt membrane

ddx of exclusion

must check for hep c and hiv

22
Q

Hypochromic microcytic anemia

elevated iron

decreased TIBC

A

sideroblastic anemia

23
Q

coombs test detects?

A

autoimmune hemolytic anemia

24
Q

ddx of malaria

A

giemsa stain of blood

25
Q

Auer rods are seen in?

A

AML

26
Q

Leukocyte adhesion deficiency

A

impaired PMN migration

deleyed umblical cord seperation

27
Q

chediak higashi

A

AR
albino
recurrent skin infections

28
Q

Post splenectomy rx

A

daily pcn x 5 years

vaccines: anti-pneumococcal, haemophilus, meningococcal (best weeks BEFORE surgery)

29
Q

deleyed umblical cord seperation

A

leukocyte adhesion deficiency

30
Q

most common bleeding problem

A

von wilebrand

prolonged bleeding and aPTT

31
Q

ABO mismatch rxn in blood transfusion

A

1 HOUR*

fever, chills, flank pain, hemoglobinuria

32
Q

TRALI

A

6 HOURS*

pulm edema

33
Q

Most common reaction to blood transfusion

A

febrile nonhemolytic rxn

1-6 hours

fever, chills, mailase

USMLE (46 decks)

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