Heme Onc Flashcards
hereditary spherocytosis in new born
macrocytic
jaundice, splenomegally, spherocytes
ddx w/ RBC fragility test w/ glycerol lysis
Rx for child with ITP
No active bleeding= observation- most resolve 6 mo w/ no rx
bleeding: IVIG/ steroidsw
Hereditary angioedema s/s
C1 esterase deficiency
edema everywhere
ab pain from intestine edema
NO urticaria
Leukemoid rxn
WBC > 50,000 IN RESPONSE TO SEVERE INFECTION
HIGH ALK PHOS (vs CML will not have this)
major toxicity of mycophenolate
immunosupressent
bone marrow supression
examples of type 4 hypersensativity
tb skin test
allergic contact dermatitis
aquied angioedema
low C1q
SCID
absent t cells
dysfxn b cells
rx: stem cell transplant
CVID vs bruton
CVID presents later in life and is less severe
major toxcity of azathioprine
immunosupressant
diarrhea
leukopenia
hepatotoxic
etidronate is?
bisphosphonate
can you trust the g6pd assay
not really
CGD defect
NADPH oxidase
cant kill cat + bugs
most common side effect of cyclosporin
nephrotoxicity
DIC labs
- thrombocytopenia
- prolonged PT and aPTT
- low fibrinogen
- schistocytes
s/s of thrombotic throbocytopenic purpura
thrombocytopenia
hemolytic anemia
fever
neuro (ams)
Pyruvate kinase deficiency
chronic hemolysis
big liver/spleen
skin ulcers
pigmented galstones
Cancers most likely to raise AFP
testicular
liver
What causes elevation of homocystine
folate or b12 deficiency
Haptoglobin is decreased in?
hemoytic anemia
Most common cause of isolasted thrombocytopenia
ITP
IgG vs plt membrane
ddx of exclusion
must check for hep c and hiv
Hypochromic microcytic anemia
elevated iron
decreased TIBC
sideroblastic anemia
coombs test detects?
autoimmune hemolytic anemia
ddx of malaria
giemsa stain of blood
Auer rods are seen in?
AML
Leukocyte adhesion deficiency
impaired PMN migration
deleyed umblical cord seperation
chediak higashi
AR
albino
recurrent skin infections
Post splenectomy rx
daily pcn x 5 years
vaccines: anti-pneumococcal, haemophilus, meningococcal (best weeks BEFORE surgery)
deleyed umblical cord seperation
leukocyte adhesion deficiency
most common bleeding problem
von wilebrand
prolonged bleeding and aPTT
ABO mismatch rxn in blood transfusion
1 HOUR*
fever, chills, flank pain, hemoglobinuria
TRALI
6 HOURS*
pulm edema
Most common reaction to blood transfusion
febrile nonhemolytic rxn
1-6 hours
fever, chills, mailase
