Hematologic Disorders Flashcards
- where RBC & platelets made
•Bone marrow
• – removes old red blood cells from circulation
Spleen
•Blood –
Contains RBCs, WBCs, clotting factors, protein, plasma, platelets, electrolytes, enzymes, and hormones.
›Transports oxygen, nutrients, cellular waste
›Regulates body temperature, pH, fluid balance
›4-6 L, 52-62% is plasma, 38-48% are cells
›Produced by red bone marrow
›Acts as a transportation medium
•Red blood cells (erythrocytes
) – transports O2 and CO2
›Biconcave, without nuclei, carry O2 bonded to the iron in Hgb
›Need sufficient protein and iron in diet to synthesize Hgb, folic acid, Vit B12
›Live for about 120 days
›Heme portion of Hgb is converted to bilirubin when RBCs become fragile and are phagocytized, if bilirubin isn’t excreted properly jaundice occurs
Type A blood
A and O blood
Tybe B blood
b and o blood
Type o blood
Can only receive type o
Universal donar
Type AB blood
aB, a, b, o
Universal recipient
RH+
rH + and -
RH-
RH- only
Age related changes
- Bone marrow becomes less productive
- Hematologic function not affected unless a person is unusually stressed with trauma, a chronic illness, or treatment for cancer
- In conditions necessitating a higher production of blood cells, bone marrow usually responds to the increased demand, given time
Nursing asses.
- Inquire about bruising easily, bleeding for an unusually long time, or chronic fatigue
- May be the symptoms of an underlying hematologic disorder
Family hx
- Sickle cell disease or hemophilia
* Death of a family member at a young age for reasons other than trauma may indicate a genetic hematologic disorder
: using the patient’s own blood
›Patient donates blood several times before procedure
›Blood is stored by the blood bank and reinfused into the patient if needed intraoperatively or postoperatively
•Autologous transfusion
›When platelet count falls
•Platelet transfusion
›Plasma separated from whole blood by centrifugation and quickly frozen
›Contains all the clotting factors as well as the plasma proteins
›Cryoprecipitate contains only fibrinogen and factor VIII; can be further separated out from plasma and administered alone
•Fresh frozen plasma transfusions
Immune system attacks red blood cells of the donor
Reaction of blood transfusion
Hemolytic
Immune system attacks white blood cells of the blood
Reaction of blood transfusion
Febrile
Allergic reaction hives and itching
Reaction of blood transfusion
Anaphylactic
Person revives to much blood overload of heart
Reaction of blood transfusion
Circulatory overload
S/s blood transfusion reaction
•Back or chest pain, fever, chills, decreased blood pressure, urticaria, wheezing, dyspnea, or coughing during the transfusion
Blood transfusion reactions intervention
- Stop transfusion immediately; keep intravenous line open with normal saline
- Immediately notify physician, nursing supervisor, blood bank
- Be prepared to administer oxygen, epinephrine, Solu-Cortef, furosemide (Lasix), antipyretics as prescribed by physician
- Save the unused portion of the blood bag for the blood bank
- Stimulates bone marrow to produce more red blood cells
- Effects on the hematocrit not apparent for several days; not an option for patients immediately needing to elevate their red blood cell counts
›Erythropoietin (Epogen)
•Too many red blood cells are produced
•Increased cells make blood more viscous (thicker); doesn’t circulate freely throughout body
Can turn face red
Polycythemia Vera