GYN Cancer Flashcards

1
Q

Is cervical carcinoma more prevalent among old or younger women?

A

younger women

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2
Q

What are some etiological factors contributing to gynecological cancers? (6 answers)

A

Poor, early sexual activity, multiple partners, pelvic lesions (HPV & HSII), Smoking, Nulliparity

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3
Q

What had helped to increase the early detection of cervical cancer?

A

Pap smears

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4
Q

what portion of cervical cancer is caught in the early non-invasive stage?

A

2/3

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5
Q

What is a gynecologic cancer risk factor specific to married women? (1 answer)

A

Those with husbands that have penile cancer

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6
Q

What does the effect of DES (Diethylstilbestrol) have on the risk for gynecological cancer?

A

Those that were exposed to DES before birth have a higher risk to develop Clear Cell Cervical and Vaginal cancer

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7
Q

What is attributing to the increase in endometrial cancer? (2 answers)

A

An aging population, Diets high in fats and calories

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8
Q

What is the peak incidence age for gynecological cancer?

A

58

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9
Q

What are two other health conditions that contribute to the occurrence of gynecological cancer?

A

Diabetes and hypertension

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10
Q

Those that are 50 lbs heavier are likelier to develop gynecological cancer. True or False?

A

True, 9x more likely

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11
Q

What are the nodes involved in the gynecological cancer region? ( 5 answers) “Physicians Commonly Intervene Extra Objectively”

A

Periaortic, Common Iliac, Internal Iliac, External Iliac, and Obturator Nodes

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12
Q

What is the outermost portion of the Gyn tract?

A

Vulva

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13
Q

What are the three sections of the vulva?

A

Labia majora, Labia Minora, and Clitoris

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14
Q

Where is the perineum located in female anatomy?

A

Between the vulvovaginal complex and anal verge

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15
Q

Explain the vagina. Characteristics? Dimensions? Location? ( 4 answers)

A

Muscular tube, 6-8 inch sup from the vulva, Ant to rectum, and Post to Bladder

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16
Q

What is the most inferior portion of the uterus that extends into the apex of the vagina?

A

The cervix

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17
Q

Explain the cervix. Characteristics? ( 3 answers)

A

Firm/round structure, 1.5 cm to 3 cm diameter, protrudes into the vagina creating spaces called fornices

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18
Q

Explain the Cervical Os. (1 answer)

A

canal the extends into the vagina through the cervix into the uterine cavity

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19
Q

Explain the Uterus. Characteristics? Dimensions? Location? (4 answers)

A

Hollow muscular structure, Overlays the bladder, extend laterally to fallopian tubes (transfer tube for eggs into the uterus), and Parametrium is tissue lateral to the uterine cervix

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20
Q

What are three important structures to consider in gynecological cancer?

A

Bladder, rectum and Small Bowel

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21
Q

What portion of the anatomy should be considered in the treatment design for gynecological cancer? ( 2 answers)

A

Primary lesions and draining lymphatics (inguinal, Pelvic and Para-aortic)

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22
Q

What is the most common malignant female genital carcinoma?

A

Endometrium Cancer

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23
Q

Endometrium cancer is ___ most common in women.

A

4th

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24
Q

What is the mucous membrane lining the uterus called?

A

Endometrium

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25
Q

What is the smooth muscle portion of the uterus called?

A

Myometrium

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26
Q

What is the outer portion of the uterus called?

A

Perimetrium

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27
Q

What two factors are contributing to the increase in endometrial cancer?

A

Hormone exposure w/o progesterone and obesity (3-5x more likely)

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28
Q

What does endometrium cancer present as? (2 answers)

A

Postmenopausal bleeding (1/3 of experience is cancer) and sometimes putrid discharge

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29
Q

What percentage of gynecological diagnosis are early stage?

A

80%

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30
Q

What are some prognostic factors for endometrial cancer? (4 answers)

A

Grade, Depth of Invasion, Nodal involvement, Tumor size

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31
Q

What is the gold standard for the detection of endometrial cancer?

A

Fractional dilation and curettage

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32
Q

What are some technologies used for diagnostics of endometrial cancer? (4 answers)

A

CT/MRI, Cystoscopy, Proctoscopy, and CA-125 levels

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33
Q

What is the staging system used for endometrium cancer?

A

FIGO staging, (only difference is FIGO staging indicates the depth of invasion)

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34
Q

What is the relative 5-year survival rate for endometrium cancer?

A

15-90% depending on staging

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35
Q

What is the most common histology of endometrial cancer?

A

Adenocarcinoma

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36
Q

What is the method of spread for endometrial cancer? (2 answers)

A

Pelvic and Para-aortic nodes

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37
Q

What are the treatment options for endometrium cancer? (3 answers)

A

Surgery, RT, and Chemo ( all depend on stage, grade, and status)

38
Q

What does TAH stand for in gynecological cancer situations?

A

Total Abdominal hysterectomy

39
Q

What is the radiotherapy regime used for endometrial cancer?

A

EBRT with 50 Gy boost to 75 Gy brachytherapy

40
Q

What is the name of the devices used to aid in the treatment of the vaginal cuff? (2 answers)

A

Vaginal Cylinders and Colpostats

41
Q

What type of imaging is used for treatment planning?

A

Orthogs

42
Q

Describe the simulation/set-up for endometrial cancer. ( 3 answers)

A

Pt flat, pillow for comfort, immobilize feet,

43
Q

What other devices are utilized in simulation to add image clarification? (2 asnwers)

A

Rectal and Vaginal markers

44
Q

What are the critical structures to consider when treating endometrium cancer?

A

Endometrial cavity (75-90 Gy), Bladder/Rectum (65-75 Gy), Small bowel (below 50 Gy), Nodes (45-50 Gy)

45
Q

What age group does ovarian cancer mostly affect?

A

50-70 yo

46
Q

Ovarian cancer is the ____ leading cause of cancer deaths in women.

A

5th

47
Q

What are some of the risk factors for Ovarian Cancer? ( 6 answers)

A

Older age, Family History, Late/Few pregnancies, Late menopause, Other cancer history, Diets high in meats and fats.

48
Q

What is the most deadly of the Gyn Cancers?

A

Ovarian Cancer

49
Q

Why is ovarian cancer so deadly?

A

Symptoms don’t present until widely disseminated

50
Q

What are the common symptoms of Ovarian Cancer? (4 answers)

A

Abdominal, Pelvic Pain, Nausea, and Constipation

51
Q

What is the route of spread for ovarian cancer?

A

into the abdominal cavity lymph nodes through pelvic nodes

52
Q

What percentage of Ovarian Cancers are epithelial?

A

90%

53
Q

What staging system is used for ovarian cancer?

A

FIGO

54
Q

What is the treatment of choice for early-stage ovarian cancer?

A

TAH with bilateral salpinhoopherectomy

55
Q

What is the treatment of choice for epithelial ovarian tumors?

A

Debulking and surgical evaluation

56
Q

What is true about early-stage ovarian cancer?

A

Usually have good outcomes

57
Q

In the case of ovarian cancer, XRT is often given pre or post-op?

A

Post-op

58
Q

The entire peritoneal cavity is included in the treatment field for ovarian cancer. True or False?

A

True

59
Q

Cervical carcinoma is more prevalent among what demographics?

A

Younger women 20-50, Poor women and early sexual active women

60
Q

What two viruses are found in 99% of cervical cancers?

A

HPV 16 and 18

61
Q

What two lifestyle factors influence the risk of cervical cancer?

A

Nulliparity and Smoking

62
Q

What does cervical cancer present as?

A

Bleeding, Slow growing, Hematuria and discharge

63
Q

At what age are routine pap smears recommend for women?

A

21

64
Q

What are diagnostics taken for cervical cancer?

A

Colposcopy with biopsy for abnormal pap smear

65
Q

What are some imaging diagnostics utilized for Cervical cancer?

A

PET/CT, MRI. Cytoscopy, and Proctoscopy

66
Q

What are some of the lymph nodes involved in cervical cancers?

A

Parametrial, Pelvic, Common iliacs and paraaortics.

67
Q

In the case of Cervical cancer, increased invasion means?

A

Poor outcome

68
Q

What is the most common histology of cervical cancer?

A

Squamous Cell Carcinoma

69
Q

What staging system is used for cervical cancer?

A

FIGO

70
Q

What is the treatment of choice for early-stage cervical cancer?

A

TAH with a small vaginal cuff dissection

71
Q

Whats a hysterectomy?

A

Removal of uteres

72
Q

What is the difference between a total and radical hysterectomy

A

Total involves the removal of the cervix and radical involved the removal the vagi

73
Q

what is the advantage of brachytherapy?

A

high does to tumor with little exposure to critical structures

74
Q

What is the advantage,e of placing the patient prone for cervical cancer?

A

Allows the bowel to be placed outside the field

75
Q

What are some devices used for the cervix during the process of radiotherapy?

A

Rectal/vagina markers, rectal barium

76
Q

Where is point A for cervical cancer?

A

2 cm superior to cervical os and 2 cm lateral to the endometrial cancer

77
Q

Where is point B for cervical cancer?

A

3 cm lateral from Point A

78
Q

What does vuvla cancer present as?

A

suspicious lump, exophytic, labia majora (most common)

79
Q

What age group does ovarian cancer mostly affect?

A

Women less than 50

80
Q

What is the predictable vulvar cancer lymphatics spread?

A

Superficial inguinal, Deep femoral and then eventually pelvic nodes

81
Q

What are diagnostics taken for vulva cancer?

A

CT and cystourethroscopy

82
Q

What is the often used treatment for vuvlar cancer?

A

vulectomy with node dissection

83
Q

What are some symptoms of vulva cancer?

A

Most desquamation and smaller tissue thickness, which can be resolved with bolus

84
Q

What is the 5-year survival rate for Vulva cancer?

A

70%

85
Q

Why is it important to have a vuvla cancer patient set-up uniquely? (pt frog legged and bolus)

A

Patients need to physically widen the field being treatment and also bolus is used to bring the dose higher on the skin

86
Q

What is the most common location of vulva cance?

A

posterior third fo vagina

87
Q

What is the dose limit for endometrial cancer?

A

45-50 Gy, boost to 10-15 Gy

88
Q

What is the dose limit for vuvla cancer?

A

50 Gy, boot to 15-20 Gy

89
Q

What is the dose limit for cervical cancer?

A

45 Gy, boost to 10-15 Gy

90
Q

What is the dose limit for vaginal cancer?

A

45-50 Gy