Glaesserella (H) parasius

Question 1

what animal is it specific for

Answer 1

specific for swine

Question 2

what blood factors does it require
hemolysis?

Answer 2

requires factor V (NAD) only
non hemolytic

Question 3

glassers disease

Answer 3

polyserositis

Question 4

glasser’s disease – who susceptible

Answer 4

pigs infected with PRRS or from SPF herds susceptible

Question 5

glasser’s disease – age of pigs affected

Answer 5

young pigs – nursery mortality

Question 6

glasser’s disease – lesions

Answer 6

fibrinous inflammation of serous surfaces
purple ears
fibrin on pericardium and liver
blood clot in trachea
pericarditis

Question 7

respiratory disease in who

Answer 7

older pigs after previous infection (mycoplasma or virus)

Question 8

symptoms

Answer 8

lameness
meningitis
serofibrinous pleurisy
pericarditis
peritonitis

Question 9

virulence

Answer 9

capsule
LPS (LOS)
adherence factors
membrane proteins
lipid A (LOS) – endotoxic, inflammation
no known exotoxins

Question 10

are there any exotoxins

Answer 10

no known exotoxins

Question 11

compromising factors

Answer 11

viral
stress (but not required)
disease is predominantely result of host inflammation (trying to remove pathogen but can’t)

Question 12

why is stress not required

Answer 12

newborns are already compromised

Question 13

immunity

Answer 13

antibodies to capsule, LOS, membrane proteins
humoral immunity most important

Question 14

what type of immunity is most imporant

Answer 14

humoral immunity is most important

Question 15

vaccination, treatment, prevention

Answer 15

bacterins – homologous serotypes
attenuated live vaccine
antimicrobials
maternal antibodies
incidental exposure at 3-5 days old with low dose of less virulent serotypes (risky)