Burkholderia pseudomallei Flashcards
respiration
gram
shape
motility
staining
facultative? intracellular?
aerobic
gram negative
rod, bacillus
motile
bipolar staining (safety pin appearance)
facultative intracellular pathogen – can stay dormant for years
servoir
soil
water
diseases
melioidosis – clinically similar to glanders, but contact with infected environment rather than infected animal
whitmore’s disease
pseudo glanders
lesions
abscess in many organs
local skin ulcers
chronic abscess
granuloma
chronic pneumonia
acute septicemia
bioterrorism?
category B bioterrorism agent
report to department of health
virulence
little known
capsule
LPS
multiple secretion systems
quorum sensing (biofilm)
type IV pili
exotoxins
protease
disease in sheep
lung abscesses
pneumonia
disease in goats
mastitis
disease in pigs
asymptomatic spleen lesions found at slaughter
disease in horses
pseudo glanders, symptoms similar to glanders
disease in dogs and cats
multiple organs abscesses
disease in cows
pneumonia
rarely affected
disease in humans
pneumonia, abscesses, subclinical
blood agar and macconkey agar
musty odor
greyish white colonies
non hemolytic
treatmetn
antibiotics – drug resistance, relapse common
surgical drainage of large abscesses
enucleation – eye infections
no vaccines, no effective treatment or control
