Actinobacillus pleuropneumoniae Flashcards
host specificity?
absolutely specific for pigs
swine trasnferrin for iron
grow requiremnets of Biovar 1 and Biovar 2
Biovar1 – V factor (NAD), chocolate agar
Biovar2 – does not require NAD
hemolysis?
hemolytic on chocolate agar
virulence of serotypes
1 and 5 fairly virulent
7 not so much
swine plwuropnemoniae
fibrinous pleuritis
hemorrhagic and necrotic lesions
subclinical to acute infections
chronic infections and carriers?
common
spread disease to non immune herds
symptoms
trembling
anorexia
dyspnea
fever
hemorrhage form nose and mouth
what can happen when animals recover
can carry bacteria and be source of new infection
virulence
capsule
LPS
RTX exotoxins – lytic for red and white blood cells
adhesins
compromising factors
opportunistic pathogen
some serotypes highly virulent (not all produce same exotoxins, so compromising factors still needed)
disease more severe due to stress, previous infection, overcrowding
what makes disease more severe
stress
previous infection
overcrowding
immunity
protection predominately provided by neutralizing antibodies to RTX (repeats in toxins) toxin
hat are the repeats in RTX
glycine and aspartate
vaccination
bacterins cannot induce neutralizing antibodies to exotoxins (labile, not stable)
live attenuates vaccines most effective as long as they include neutralizing antibodies to toxins
control
management
all in all out farm practices
