Germ Cell Ovarian Tumours Flashcards
Examples of Germ cell tumours?
-Dermoid cyst/ Mature Cystic Teratoma
-Immature Teratoma
-Dysgerminoma
-Yolk Sac tumour
-Choriocarcinoma (asssociated with complete molar pregnancy)
-Mixed germ cell tumour
what is a dermoid cyst/ mature cystic teratoma?
type of ovarian germ cell tumour (95% of all germ cell tumours) that contains various type of tissue
who is most likely to get a dermoid cyst/ mature cystic teratoma?
-Young women
-Occur frequently in pregnancy
-Associated with ovarian torsion
are dermoid cysts/ mature cystic teratomas benign or malignant?
Typically benign
-rarely become malignant e.g. SSC in skin of a teratoma
what markers may be raised in dermoid cysts/ mature cystic teratomas?
alpha- fetoprotein
hCG
what is an immature cystic teratoma?
-dermoid cyst that has immature foetal tissue
-this is very rare
what is the most common malignant primitive germ cell tumour?
Dysgerminoma
What other tumour is a dysgerminoma similar to?
seminoma in testes
who is mostly affected by dysgerminoma?
children and women
how does a dysgerminoma present histologycally?
what is increased in bloods of someone with dysgerminoma?
LDH and hCG
how do dysgerminomas predominantly spread?
via lymphatic spread
how do yolk sac tumours present on histology?
Fried egg appearance
Schiller- Duval bodies
SAC
Schiller- Duval bodies
AFP raised
Children
bloods of someone with Yolk Sac tumour?
raised AFP
SAC
Schiller- Duval bodies
AFP raised
Children
who is most commonly affected by yolk sac tumours?
Children
SAC
Schiller- Duval bodies
AFP raised
Children
