Genomics 1 Flashcards
What is genomics ?
Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes
what are the 4 research areas of genomics ?
- Functional Genomics
- Structural Genomics
- Epigenomics
- Metagenomics
what is functional genomics ?
a field of molecular biology that attempts to make use of the vast wealth of data produced by genomic projects to describe gene (and protein) functions and interactions
What is structural genomics ?
the 3-D structure describtion of every protein encoded by a given genome
what is epigenomics ?
is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome
what is metagenomics ?
the study of metagenomes, genetic material recovered directly from environmental samples
what is metagenomics ?
the study of metagenomes, genetic material recovered directly from environmental samples
how does personalised medicine use genetics ?
- predict disease development
- influence decisions about lifestyle choices
- tailor treatment to the individual
what is pharmacogenomics ?
the study of how genes affect a person’s response to drugs.
what is pharmacogenomics ?
the study of how genes affect a person’s response to drugs.
case studies in pharmacogenomics ?
Codeine
Warfarin
Abracavir
Antibiotics for treatment of tuberculosis
What is Warfarin ?
- Most widely prescribed oral anticoagulant for preventing thrombolytic events, despite its narrow therapeutic range
- Needs to be taken at s specific time each day
who is Warfarin prescribed to ?
- those at risk of blood clots – strokes, embolisms, DVTs, heart attacks
what can overdo of Warfarin cause ?
substantial increased risk for bleeding complications
