Gastro Flashcards

1
Q

Irritable Bowel Syndrome (IBS)

A

Definition: Chronic condition with recurrent abdominal pain and bowel habit changes.

Prevalence: Affects ~30% of Australians.

Symptoms & Triggers: Abdominal pain, bloating, constipation/diarrhea; triggered by stress, food intolerances, certain medications.

Management: Low FODMAP diet (75% effective), high-fiber foods, reduced gas-producing foods, gut-directed hypnotherapy.

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2
Q

FODMAPs

A

Definition: Poorly absorbed short-chain carbs causing gas and bloating.

Types:
Oligosaccharides: Fructans (wheat, garlic), GOS (legumes).
Disaccharides: Lactose (dairy).
Monosaccharides: XS fructose (fruit, honey).
Polyols: Sugar alcohols (sorbitol, mannitol).

Diet Phases:
Elimination: Avoid high FODMAPs (2-6 weeks).
Reintroduction: Gradually reintroduce foods (6-8 weeks).
Maintenance: Sustainable, less restrictive diet.

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3
Q

Diverticular Disease

A

Diverticulosis: Formation of pouches in the colon, typically asymptomatic.

Diverticulitis: Inflamed or infected pouches, causing severe pain, fever, nausea, and bowel habit changes.

Treatment:
Diverticulosis: High-fiber diet, fluid intake, probiotics.
Diverticulitis: Low-residue diet during flares; severe cases require antibiotics or surgery.

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4
Q

Constipation

A

Definition: Infrequent passage of stools with straining or discomfort.

Types:
Primary: Functional (normal or slow transit, pelvic floor dysfunction).
Secondary: Due to medical conditions, medications, or structural issues.

Prevalence: Up to 24%; 80% in elderly.

Dietary Goals: 25-30g fiber/day, adequate hydration, physical activity.

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5
Q

First-Line IBS Dietary Advice

A

Include: High-fiber foods (whole grains, legumes, fruits, vegetables).

Avoid/Limit: Gas-producing foods (onion, cabbage), lactose, alcohol, artificial sweeteners.

Key Foods to Avoid: Garlic, onion, apples, mushrooms, bread, chickpeas (high FODMAP).

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6
Q

Fibre Overview

A

Types:
Soluble: Found in oats, beans, and fruit; lowers cholesterol, stabilizes blood sugar.

Insoluble: Found in whole grains, fruit skins, vegetables; promotes regularity.

Resistant Starch: Found in cooled rice, underripe bananas; feeds healthy gut bacteria.

Daily Targets: 25g for women, 30g for men.

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7
Q

Toileting Habits for Constipation

A

Optimal Timing: After waking or meals when the bowel is most active.

Posture: Knees above hips, feet flat.

Avoid Distractions: Reading or phone use during toileting.

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8
Q

Treatment Options for Constipation

A

Mild Cases: High-fiber diet, fluid intake, physical activity, trial probiotics.

Severe Cases: Use of fiber supplements, laxatives (bulking agents, stool softeners, stimulants).

Advanced: Colonic transit study, pelvic floor therapy, or medical intervention.

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9
Q

High-Fiber Food Examples

A

Grains: Wholemeal pasta (7.9g/cup), rolled oats (4.5g/½ cup).

Vegetables: Carrot (6.9g), broccoli (3.8g).

Fruits: Dried apricots (2.5g), apple (2.2g).

Legumes: Kidney beans (6.5g/100g).

Nuts: Almonds (3g/30g).

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10
Q

Diverticulosis Recommendations

A

Dietary Goals: Gradual fiber increase (25-30g/day) and hydration (35-45 ml/kg/day).

Other Tips: Avoid alcohol/caffeine; don’t restrict nuts/seeds unnecessarily.

Probiotics: Optional, avoid during acute diverticulitis.

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11
Q

Definition of IBD

A

Chronic inflammatory condition including Crohn’s Disease (CD) and Ulcerative Colitis (UC).

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12
Q

IBD Nutritional Requirements

A

Energy Needs: Generally 30-35 kcal/kg/day; may increase during active disease due to inflammation.

Protein Needs: Increased during active disease (1.2-1.5 g/kg/day); similar to general population during remission (~1 g/kg/day).

Micronutrient Monitoring: Annual assessment for deficiencies, focusing on iron, vitamin D, zinc, selenium, and vitamin B12.

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13
Q

Nutritional Strategies for Active IBD

A

Exclusive Enteral Nutrition (EEN): First-line treatment for inducing remission in pediatric CD; alternative for adults with mild to moderate CD who cannot tolerate drugs.

Crohn’s Disease Exclusion Diet (CDED): Effective in combination with partial enteral nutrition, especially in pediatric patients.

Diet Texture: Modified or liquid diets for patients with strictures or intestinal obstruction.

Supplementation: Address deficiencies of calcium, vitamin D, and iron based on active disease and treatment plans.

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14
Q

IBD Micronutrient Management

A

Iron: Oral iron is preferred in mild anemia and inactive disease. Intravenous iron recommended for severe anemia or active inflammation.

Vitamin D & Calcium: Supplement in corticosteroid use or suspected deficiencies to prevent osteoporosis.

B12 & Folate: Essential after ileocecal resection or methotrexate/sulfasalazine treatment.

Fat-Soluble Vitamins (A, D, E, K): Supplement in cases of fat malabsorption or prolonged disease activity.

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15
Q

IBD Dietary Patterns & Prevention

A

Dietary Risk Factors: Ultra-processed foods and emulsifiers may increase IBD risk; fiber and omega-3 intake offer protection.

Breastfeeding: Reduces risk of developing IBD.

Dietary Goals: Healthy, balanced diet focusing on fruits, vegetables, whole grains, and lean proteins during remission.

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16
Q

EN & PN in IBD

A

EN as Supportive Therapy: Used when oral feeding is insufficient; standard polymeric diets are preferred.

PN Indications: Severe malabsorption, short bowel syndrome, or gastrointestinal obstruction.

Administration: Nasogastric or nasoenteric routes preferred; pump feeding is optimal for jejunal feeding.

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17
Q

IBD Post Surgical Nutrition

A

Assessment: Evaluate nutritional status before and after surgery.

Nutritional Support: Oral nutrition with supplements preferred post-surgery; PN if oral or EN is not feasible.

Micronutrient Focus: Maintain adequate levels of iron, B12, calcium, and vitamins D, A, E, and K.

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18
Q

IBD Management During Remission

A

Dietary Advice: Maintain a healthy diet and avoid known food triggers.

Nutritional Supplements: Use oral supplements or EN if malnutrition persists.

Lifestyle Considerations: Encourage regular meal patterns and physical activity to maintain nutritional health.

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19
Q

Osteoporosis risk in IBD

A

Common in IBD; ensure regular DEXA scans and supplement with calcium and vitamin D.

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20
Q

Dehydration Management in IBD

A

Critical in patients with high-output stomas or severe diarrhea; consider tailored oral rehydration solutions.

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21
Q

IBD General Overview

A

IBD Types: Crohn’s Disease (CD) and Ulcerative Colitis (UC).

Disease Characteristics:
CD: Inflammation from mouth to anus; affects all bowel layers.
UC: Limited to the mucosal lining of the colon and rectum.

Symptoms: Abdominal pain, diarrhea, malabsorption, weight loss, fatigue, and nutrient deficiencies.

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22
Q

IBD Nutritional Status Considerations

A

Risk of malnutrition, growth retardation (children), and osteoporosis (prolonged steroid use).

Micronutrient deficiencies: iron, B12, vitamin C, vitamin D, calcium, fat-soluble vitamins, zinc.

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23
Q

IBD Dietary Modification Considerations

A

CD: Low-fat, low-fiber diets during active disease (LOFLEX protocol).

UC: Avoid specific food triggers; balanced diet.

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24
Q

Dietary management in active IBD

A

General Guidelines:
High-protein (1.2–1.5 g/kg/day).
Energy needs: 30–35 kcal/kg/day.

Elemental Diet: Pre-digested nutrients, suitable for severe disease but may exacerbate diarrhea due to high osmolarity.

Polymeric Diet: Standard feeds with intact nutrients; fiber contraindicated during active flares.

Exclusive Enteral Nutrition (EEN):
First-line therapy in pediatric CD.
Partial EN with tailored diets for adults with UC or CD.

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25
Q

Nutritional Management During IBD Exacerbations

A

Goals: Minimise nutrient losses, manage symptoms, and maintain intake.

Interventions:
Oral nutritional supplements (ONS).
Enteral Nutrition (EN) if oral intake is insufficient.
Parenteral Nutrition (PN) for severe malabsorption or bowel dysfunction.

Modified Fiber Diet: Low fiber, low lactose, adequate fluids during diarrhea.

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26
Q

Nutritional Strategies During IBD Remission

A

Goals: Maintain nutritional status and prevent relapse.

Diet Recommendations:
Healthy, varied diet: focus on fruits, vegetables, whole grains, and lean proteins.
Modified high-energy, high-protein diet if indicated.
Micronutrient monitoring: vitamin D, calcium, iron, zinc.

Exclusive EN: Alternative to steroids in maintaining remission, especially in pediatric CD.

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27
Q

Surgery and Post-Surgical Nutrition in IBD

A

Surgical Options:
- UC: Total colectomy can be curative.
- CD: Surgery to manage symptoms; not curative.

Nutritional Impact: Ileostomy/colostomy increases fluid loss and reduces absorption.

Dietary Adjustments:
- Avoid high-fibre, odorous foods; manage flatulence and stool frequency.
- Balanced diet and supplementation to maintain nutrition.

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28
Q

IBD Micronutrient Management

A

Iron & B12: Address anemia and deficiencies due to malabsorption or ileal damage.

Vitamin D & Calcium: Prevent osteoporosis, especially during steroid use.

Fat-Soluble Vitamins (ADEK): Supplement in cases of fat malabsorption.

Zinc & Folate: Supplement to support immune function and repair.

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29
Q

MNT for Paediatric IBD

A

Focus on Growth: Early intervention with EN to support growth and nutritional status.

CDED (Crohn’s Disease Exclusion Diet):
- Combined with partial EN for achieving remission.
- Gradual reintroduction of foods to identify triggers.

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30
Q

LOWFLEX protocol

A

Low fat, fibre limited exclusive diet

Initial low-fat (50g/day), low-fiber (10g/day) diet for 2–4 weeks.

Gradual reintroduction of foods to identify triggers.

31
Q

IBD Nutritional Management in Special Situations

A

Acute Phase: Modified fibre, low lactose, vitamin and mineral supplements, PN if needed.

Long-Term: General healthy eating guidelines, individualized to maintain remission.

32
Q

Additional IBD considerations

A

Hydration: Adequate fluids for patients with diarrhea or stomas.

Fat Malabsorption: Assess and treat as needed.

Prolonged Steroid Use: Manage associated risks like osteoporosis and micronutrient depletion.

33
Q

Steroid Use in IBD

A

Purpose: Steroids (e.g., prednisone, budesonide) manage acute IBD flare-ups by reducing inflammation.

Common Side Effects: Arise with high doses or prolonged use.

34
Q

Short-term side effects of steroids

A

Increased Appetite & Weight Gain: Fat deposition in the face, neck, and abdomen.

Mood Swings: Anxiety, irritability, or mood disorders.

Insomnia: Difficulty falling or staying asleep.

Increased Blood Sugar: Higher risk in pre-diabetic or diabetic individuals.

Fluid Retention & Swelling: Sodium and water retention causing swelling in extremities and face.

35
Q

Long-term side effects of steroids

A

Osteoporosis: Weakening of bones; higher fracture risk.

Cataracts: Vision problems from prolonged use.

Skin Changes: Fragile, thin skin prone to bruising.

Muscle Weakness: Reduced muscle mass and strength.

Suppressed Immunity: Increased infection risk.

Growth Retardation (Children): Potential impact on growth and development.

Adrenal Gland Suppression: Reduced cortisol production, leading to insufficiency when steroids are tapered off.

36
Q

Steroid impact on nutrient malabsorption

A

Calcium: Reduced absorption and increased excretion → osteoporosis risk.

Potassium: Increased urinary loss → hypokalemia.

Sodium: Retention → high blood pressure, electrolyte imbalances.

Protein: Increased breakdown → muscle wasting.

Vitamin C: Reduced absorption → decreased antioxidant levels.

Vitamin D: Impaired metabolism → reduced calcium utilization and bone health.

37
Q

Steroid Use Management Strategies in IBD

A

Lowest Effective Dose: Use steroids at the minimum effective dose and duration.

Nutritional Support:
- Supplement calcium, vitamin D, and potassium as needed.
- Include high-protein foods to offset muscle breakdown.
- Monitor nutrient levels (e.g., vitamin C, protein, and electrolytes).

Alternative Therapies: Consider non-steroidal medications to reduce reliance on steroids.

38
Q

Definition of eosinophilic oesophagitis

A

Allergic condition causing inflammation in the esophagus, leading to impaired contraction.

39
Q

Prevalence of eosinophilic oesophagitis

A

More common in men than women.

40
Q

Dietary management of eosinophilic oesophagitis

A

6-food elimination diet: Avoid animal milk, wheat, egg, soy, nuts, fish, and shellfish.

2-food elimination diet: Focus on eliminating milk and wheat first.

41
Q

GORD definition

A

Reflux occurring more than twice a week due to an incompetent esophageal sphincter.

42
Q

Medical management of GORD

A

Antacids: Gaviscon.

Prokinetics: Promote stomach emptying.

PPIs: Omeprazole (take 30-60 minutes before meals).

H-2 Receptor Blockers: Reduce acid production.

Some medications can worsen symptoms.

43
Q

Surgical management of GORD

A

Laparoscopic Nissen Fundoplication

44
Q

MNT of GORD

A

Aim for BMI ≤ 25; a BMI reduction of 3.5 can reduce symptoms by 40%.

Avoid alcohol, caffeine, fatty foods, acidic/creamy/fizzy foods, and peppermint tea.

Sit upright after meals; avoid drinking with meals.

Stop gum chewing.

45
Q

Complications associated with GORD

A

Barrett’s esophagus, dysphagia, ulceration, odynophagia, otitis media, chest pain.

46
Q

Causes of GORD

A

Overweight, age, genetics, pregnancy, trauma, hiatus hernia.

47
Q

Overview of absorption in the GI tracts (stomach -> lower GI)

A

Stomach: Intrinsic factor binds to B12; pancreatic enzymes released.

Small Intestine:
Jejunum: Absorbs CHO, protein, water-soluble vitamins.
Ileum: Primary site for bile salt and B12 absorption.

Lower GI Tract: Absorbs water, vitamin K, Na, K, and SCFA.

48
Q

Normal stoma outputs (ileostomy & colostomy)

A

Normal output: 600–1000 ml/day, toothpaste consistency.

Colostomy:
Normal output: 300–400 ml/day, semi-solid stool.

49
Q

Definition & causes of high output stomas

A

Defined as 1500–2000 ml/day.

Causes: Inflammation, infection, SIBO, obstruction, bile salt malabsorption, medications.

50
Q

High stoma output management

A

ORS (Oral Rehydration Solution) with high salt diet.
Starch CHO to thicken output.
Low fiber intake.

51
Q

Oral rehydration solution recipe

A

St Mark’s solution:
3.5 g salt.
2.5 g sodium bicarbonate.
20 g glucose.
1L water or 2 sachets of Dioralyte.

52
Q

What is the definition of short bowel syndrome?

A

A disorder causing malabsorption, diarrhea, steatorrhea, fluid/electrolyte disturbances, and malnutrition due to inadequate functional bowel.

53
Q

What length of bowel is considered high risk for short bowel syndrome?

A

<200cm of bowel

54
Q

What is the most common cause of short bowel syndrome?

A

Crohn’s disease

55
Q

What is the normal Na+ concentration in the bowel?

A

~90–120 mmol

56
Q

What should the sodium concentration in oral rehydration solutions (ORS) for short bowel syndrome be?

A

90–120 mmol, with CHO concentration ~60 mmol.

57
Q

What type of enteral feeds are recommended for short bowel syndrome?

A

Isotonic feeds with an osmolarity of 300–500 osm/kg.

58
Q

Why should elemental feeds be avoided in short bowel syndrome?

A

They are hypertonic and can exacerbate symptoms.

59
Q

When is parenteral nutrition (PN) not required in short bowel syndrome?

A

If the ileum is intact and large portions of the jejunum remain functional.

60
Q

What is the minimum bowel length needed to avoid PN in patients without a colon?

A

At least 100 cm of bowel.

61
Q

Which medication is used to decrease stomach acid in short bowel syndrome?

A

Proton pump inhibitors (PPIs), such as omeprazole.

62
Q

Which medication can be used as an antimotility agent in short bowel syndrome?

A

Codeine phosphate.

63
Q

What supplements are necessary in short bowel syndrome due to malabsorption in the ileum?

A

Vitamin B12 and bile salts.

64
Q

What is the gold standard diagnostic test for coeliac disease?

A

Small bowel biopsy

65
Q

How is lactose intolerance diagnosed?

A

Hydrogen breath test

66
Q

How is IBS diagnosed?

A

Based on symptom criteria and excluding other conditions

67
Q

What diagnostic tools are used for ulcerative colitis?

A

Blood tests, endoscopy, stool tests, scans, colonoscopy

68
Q

What tests are used to diagnose Crohn’s disease?

A

Faecal calprotectin, MRI, CT scan

69
Q

How is diverticular disease diagnosed?

A

Colonoscopy, CT, X-ray, barium enema

70
Q

Which tests are used to diagnose GORD?

A

Endoscopy, 24hr pH monitoring, oesophageal manometry

71
Q

What are the diagnostic tests for peptic ulcer disease?

A

Endoscopy & H. Pylori testing (breath or stool)

72
Q

How can faecal calprotectin be used in differentiating between IBS & IBD?

A

Detects inflammation = present in IBD, not IBS

73
Q

What are other inflammatory markers used in GI diagnostics?

A

Erythrocyte sedimentation rate (ESR) & CRP