G45 Skull Growth and Dev Flashcards
Neurocranium
round bony case that surrounds the brain (frontal, parietal, occipital, temporal, sphenoid, and ethmoid
Viscerocranium
bones of the face derived from pharyngeal arches (maxilla, zygomatic, inferior nasal concha, lacrimal, palatine, nasal, ethmoid, and vomer)
Mandible processes
Alveolar: houses teeth, coronoid: temporalis tendon insertion, condylar: supporting the mandibular condyle
Norma frontalis
anterior view of the face
7 bones comprising the orbit
Frontal, maxilla, zygomatic, lacrimal, palatine, sphenoid, ethmoid
Orbital apertures
superior and inferior orbital fissure, nasolacrimal duct, and optic foramen
Bones comprising the piriform aperture
nasal, maxilla; vomer and perpendicular plate of ethmoid forming nasal septum; Nasal concha (middle and superior are ethmoid bone) inferior nasal concha is separate bone
Norma Lateralis
lateral view
Temporal fossa
containing the temporalis m.
Zygomatic arch
attachment site for masseter and temporalis fascia
Norma basalis
inferior view
Glenoid fossa
fossa in temporal bone forming the cranial portion of the TMJ
Pterygoid plates
projections of the sphenoid bone that serve as muscle attachment sites
Separates anterior from middle cranial fossa
sphenoidal crest
Separates the middle and posterior cranial fossa
Petrous ridge
Craniosyntosis
premature closure of a cranial suture
Scaphocephaly
long, narrow skull due to premature closure of the sagittal suture
Brachycephaly
short, wide skull due to premature closure of coronal suture
Squamosal suture
between the temporal and parietal bones
Pterion
H-shaped region on lateral side of cranium where the frontal, temporal, parietal, and sphenoid bone meet
A blow to the pterion could result in…
epidural hematoma due to the middle meningeal artery running along the interior of the pterion
Bregma
anterior fontanelle in newborns
Lambda
posterior fontanelle in newborns
Ectoderm
neural tube (CNS), neural crest (meninges, bones of face, muscles, etc), outer epithelium (skin, glands, hair, nails, lens and cornea)
Mesoderm
Paraxial mesoderm (Axial bones, muscles, and CT) Intermediate mesoderm (kidneys, reproductive, genitals) Lateral plate mesoderm (CT of body wall, GI, respiratory, vessels, limbs, heart)
Endoderm
lining of GI, auditory, respiratory, and bladder
Bilaminar disc
Week 2; epiblast and hypoblast
Epiblast
primitive ectoderm
Hypoblast
primitive endoderm
Trilaminar disc
Week 3; formation of the intraembryonic mesoderm
Primitive streak
a ridge within the epiblast and cells migrate in
Primitive node
node at the cephalic end of the primitive streak
Notochord
rod-like column forms as cells from the epiblast enter the primitive pit
neural plate
ectoderm overlying the notchord that is induced to become neural cells
Neural tube
created by invagination of the neural plate; give rise to CNS
Neural crest cells
lie adjacent to the neural tube and give rise to parts of the face and skull
Intraembryonic mesoderm
mesenchyme (undifferentiated CT) and paraxial mesoderm (somites)
Somitomeres and somites give rise to
Intraembryonic mesoderm
bones of the cranial base and posterior cranial vault (mesenchye -> osteoblasts, chondroblasts, and fibroblasts)
Neural crest mesenchyme give rise to
ectoderm
bones of the face and anterior cranial vault and base
Do ossification pathways of the skull reflect location or origin?
Reflect cranial region, NOT primordial origin
Intramembranous ossification
Flat bones, cranial VAULT, facial bones, Mesenchyme -> osteoblasts dermis replaced with bone
Endochondral ossification
rest of bones of head; mesenchyme-> chondroblasts-> osteoblasts; dermis, hyaline cartilage, bone
Cranial base ossifies via
endochondral ossification
cranial vault ossifies via
intramembranous ossification
viscerocranium ossifies via
intramembranous ossification
Cranial base bones
ethmoid, sphenoid, petrous temporal, occipital
Cranial base is derived from
BOTH neural crest cell and paraxial mesoderm
Stage 1 of Cranial BASE development
Formation of basal plate (fusion of parachordal cartilage), ethmoid plate (fusion of prechodal cartilage), olfactory capsule, otic capsule, and optic capsule
Cartilaginous Basal plate
forms from parachordal cartilage lateral to notochord, fusing across midline
Ethmoid plate
Prechordal cartilage anterior to notochord fuse
Cartilaginous Olfactory capsule
surrounds olfactory epithelium
Cartilaginous Otic capsule
surrounds otocyst
Optic capsule
forms around retina forms sclerotic coat
Stage 2 of Cranial base development
Fusion of ethmoid plate and olfactory capsule, basal plate and otic capsule, ethmoid and basal plate (hypophyseal fenestra - midline hole remains for pituitary gland)
Stage 3 of Cranial base development
Pit for pituitary gland and internal carotid, cartilaginous walls for braincase, and cartilage forms around cranial nerves and vessels (foramina)
Stage 4 of Cranial base development
Ossification; occipital center, sphenoid center, ethmoid center, and otic center (petrous temporal), synchondroses (cartilage between centers) remain until adulthood
Spheno-occipital synchondrosis fuses..
late teens
Achondroplasia
cartilage does not grow properly and the endochondral portions of the skull (cranial base) are smaller and the intramembranous portions appear enlarged
Cranial vault development - intramembranous
frontal, squamous temporal, parietal; neural crest cells become mesenchyme that settles in the SUBDERMIS and becomes fibroblasts and scleroblasts
Microcephaly
brain and braincase are abnormally small; impaired brain growth (not craniosyntosis)
Hydrocephaly
accumulation of intracranial CSF causing abnormal expansion of the braincase
External pressure has an effect on which type of ossification
Intramembranous ossification
Viscerocranium bones include… and develop…
Maxilla, mandible, lacrimal, nasal, zygomatic, vomer, and palatine; INTRAMEMBRANOUS ossification
Bones of middle ear and hyoid bone ossify via
ENDOCHONDRAL OSSIFICATION
Two main parts of the cranium
Neurocranium (bones encasing brain) and viscerocranium (facial bones)
Paired bones the contribute to the neurocranium? Unpaired?
parietal and temporal; occipital, frontal, sphenoid, ethmoid
Paired bones of the viscerocranium? Unpaired?
maxilla, zygomatic, lacrimal, inf. nasal concha, palatine, nasal; vomer, ethmoid
Craniosyntosis
premature closure of sutures; scaphocephaly and brachycephaly
What parts of the cranium form endochondrally? intramembranously?
Endo: cranial base; Intra: cranial vault and viscerocranium
Neural crest regions and paraxial mesoderm regions?
Neural: face, anterior cranial vault and base; Paraxial: Posterior cranial vault and base
Bones that form endochondrally?
occipital, sphenoid, ethmoid, petrous part of temporal