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Step 1 > Flashcards - Repro > Flashcards

Flashcards - Repro

1
Q

glomeruli-like pathology

A

Schiller-Duval bodies, yolk sac tumors

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2
Q

Reinke crystals

A

Leydig cell tumors - gynecomastia, precocious puberty - golden brown in color

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3
Q

fried egg

A

seminoma

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4
Q

granulosa cells arranged haphazardly around collections of eosinophilic fluid

A

Call-Exner bodies - granulosa cell tumors

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5
Q

koilocytes

A

condyloma - HPV 6/11

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6
Q

lower 1/3 of vagina drainage

A

urogenital sinus - inguinal nodes

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7
Q

upper 2/3 of vagina drainage

A

Mullerian ducts - regional iliac nodes

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8
Q

botryoides - bleeding grape like mass emerging from vagina - desmin/myogen+

A

embryonal rhabdomyosarcoma - affects girls under 4

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9
Q

high risk HPV

A

16, 18, 31, 33 - E6, E7 protein –> destruction p53 (BAX) and Rb (E2F)

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10
Q

low risk HPV

A

6, 11

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11
Q

acute endometritis abx

A

gentamicin + clindamysin +/- ampicillin

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12
Q

PCOS hormones

A

increased LH, decreased FSH, > 2:1

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13
Q

schiller-duval bodies (glomeruli), increased AFP

A

endodermal sinus tumor - yolk sac

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14
Q

large cells, clear cytoplasm

A

dysgerminoma

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15
Q

large primitive cells

A

ovarian/testicular - embryonal carcinoma -

testes: increased AFP, b-hCG

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16
Q

Reinke crystals

A

Sertoli-Leydig cells tumor - increased androgens

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17
Q

Kruckenberg tumor

A

metastatic gastric cancer - mucionous

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18
Q

pseudomyxoma peritonei

A

mucinous tumor of appendix

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19
Q

acute mastitis - bug/treatment

A

S. aureus/dicloxicillin

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20
Q

duct-like structures in a desmoplatin stroma, stellate infiltration, “rock hard”

A

invasive ductal carcinoma - most common (75%) worst and most invasion

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21
Q

decreased E-cadherins, Indian file cells, signet cell

A

invasive lobular cacinoma - multifocal - tx tamoxifen

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22
Q

Bowen disease

A

precursor SCC of penile shaft

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23
Q

Peyronie disease

A

fibrous plaque in tunica albuginea –> curved penis

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24
Q

cryptorchidism hormones

A

increased FSH, LH, decreaesed inhibin

25
Q

proliferative endometrium

A

nonbranching, nonbudding uniform glands that are tubular, narrow and lined with pseudostratified elongated mitotically active epithelial cells

26
Q

secretory endometrium

A

glycogen-rich mucus, edematous stroma, prominent spiral arteries

27
Q

complete mole

A

46 XX or XY paternal - “bunch of grapes”

28
Q

partial mole

A

69 XXX or XXY - normal villi and fetal tissue

29
Q

mesonephric ducts

A

Wolffian ducts - forms male tract

30
Q

paramesonephric ducts

A

Mullerian ducts - form female tract

31
Q

PCOS infertility treatment

A

clomiphene - estrogen receptor modulator - decreases negative feedback inhibition of gonadotropin from hypothalamus

32
Q

HER2/neu oncogene

A

encodes for intraceullar tyrosince kinase growth factor receptor

33
Q

polycythemia vera mutation

A

V617F mutation with JAK2 - increased marrow sensitivity to EPO and TPO

34
Q

theca interna cells

A

androgen synthesis - cholesterol to progesterone

35
Q

granulosa cell

A

aromatase - androgens to estrogen

36
Q

menopause marker

A

elevated FSH (no inhibition from estrogen)

37
Q

infundibulopelvic ligament

A

holds ovaries to lateral pelvic wall - contains ovarian vessels

38
Q

cardinal ligament

A

cervix to side wall of pelvis - contains uterine vessels

39
Q

desmolase

A

enzyme to convert cholesterol to androgens - theca cell

40
Q

arrest phase pre-ovulatoin

A

prophase I

41
Q

arrest phase pre-fertilization

A

metaphase II

42
Q

hCG production location

A

syncytiotrophoblast (outer layer of chorionic villi - low MHC I expression)

43
Q

spermatogenesis

A

spermatogonium (2N, 2C) –> primary spermatocyte (2N, 4C) –> secondary spermatocyte (1N, 2C) –> spermatid haploid (1N,1C) –> spermatozoon haploid (1N,1C)

44
Q

kallman syndrome

A

failure to complete puberty - hypogonadotropic hypogonandism - defective migration of GnRH cells and formation of olfactory bulbs - anosmia, infertility

45
Q

placental abruption

A

abrupt, painful bleeding - cocaine, HTN, smoking

46
Q

clear cell adenocarcinoma

A

DES exposure

47
Q

looks like bladder, solid pale yellowtan/encapsulated tumor - “coffee bean” nuclei

A

Brenner tumor - benign tumor of ovary

48
Q

meigs syndrome

A

triad of ovarian fibromas, ascites, hydrothorax - pulsing sensation in groin - spindle shaped fibroblasts

49
Q

serous cystadenocarcinoma

A

most common ovarian neoplasm - psammoma bodies

50
Q

adenomyosis treatment

A

GnRH agonists, hysterectomy

51
Q

leaf-like projections - large bulky mass of connective tissue/cysts

A

Phyllodes tumor - malignant potential

52
Q

small tumor in lactiferous ducts beneath areola - bloody nipple discharge

A

intraductal papilloma

53
Q

comedocarcinoma

A

DCIS with central necrosis

54
Q

Paget disease

A

from underlying DCIS - large cells in epidermis with clear halo

55
Q

lichen sclerosis

A

thinning of epidermis, fibrosis of dermis (parchment) - increased risk of SCC

56
Q

lichen simplex chronicus

A

hyperplasia of epithelium (thick leathery) - leukoplakia

57
Q

endometrial carcninoma

A

hyperplastic: estrogen exposure - endometrioid histo
sporadic: atrophic endometrium - serous/papillary/psammoma bodies

58
Q

leiomyosarcoma

A

malignant - single lesion in uterus w/ areas of necrosis/hemorrhage

Step 1 (19 decks)

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