Flashcards - Repro

Question 1

glomeruli-like pathology

Answer 1

Schiller-Duval bodies, yolk sac tumors

Question 2

Reinke crystals

Answer 2

Leydig cell tumors - gynecomastia, precocious puberty - golden brown in color

Question 3

fried egg

Answer 3

seminoma

Question 4

granulosa cells arranged haphazardly around collections of eosinophilic fluid

Answer 4

Call-Exner bodies - granulosa cell tumors

Question 5

koilocytes

Answer 5

condyloma - HPV 6/11

Question 6

lower 1/3 of vagina drainage

Answer 6

urogenital sinus - inguinal nodes

Question 7

upper 2/3 of vagina drainage

Answer 7

Mullerian ducts - regional iliac nodes

Question 8

botryoides - bleeding grape like mass emerging from vagina - desmin/myogen+

Answer 8

embryonal rhabdomyosarcoma - affects girls under 4

Question 9

high risk HPV

Answer 9

16, 18, 31, 33 - E6, E7 protein –> destruction p53 (BAX) and Rb (E2F)

Question 10

low risk HPV

Answer 10

6, 11

Question 11

acute endometritis abx

Answer 11

gentamicin + clindamysin +/- ampicillin

Question 12

PCOS hormones

Answer 12

increased LH, decreased FSH, > 2:1

Question 13

schiller-duval bodies (glomeruli), increased AFP

Answer 13

endodermal sinus tumor - yolk sac

Question 14

large cells, clear cytoplasm

Answer 14

dysgerminoma

Question 15

large primitive cells

Answer 15

ovarian/testicular - embryonal carcinoma -

testes: increased AFP, b-hCG

Question 16

Reinke crystals

Answer 16

Sertoli-Leydig cells tumor - increased androgens

Question 17

Kruckenberg tumor

Answer 17

metastatic gastric cancer - mucionous

Question 18

pseudomyxoma peritonei

Answer 18

mucinous tumor of appendix

Question 19

acute mastitis - bug/treatment

Answer 19

S. aureus/dicloxicillin

Question 20

duct-like structures in a desmoplatin stroma, stellate infiltration, “rock hard”

Answer 20

invasive ductal carcinoma - most common (75%) worst and most invasion

Question 21

decreased E-cadherins, Indian file cells, signet cell

Answer 21

invasive lobular cacinoma - multifocal - tx tamoxifen

Question 22

Bowen disease

Answer 22

precursor SCC of penile shaft

Question 23

Peyronie disease

Answer 23

fibrous plaque in tunica albuginea –> curved penis

Question 24

cryptorchidism hormones

Answer 24

increased FSH, LH, decreaesed inhibin

Question 25

proliferative endometrium

Answer 25

nonbranching, nonbudding uniform glands that are tubular, narrow and lined with pseudostratified elongated mitotically active epithelial cells

Question 26

secretory endometrium

Answer 26

glycogen-rich mucus, edematous stroma, prominent spiral arteries

Question 27

complete mole

Answer 27

46 XX or XY paternal - “bunch of grapes”

Question 28

partial mole

Answer 28

69 XXX or XXY - normal villi and fetal tissue

Question 29

mesonephric ducts

Answer 29

Wolffian ducts - forms male tract

Question 30

paramesonephric ducts

Answer 30

Mullerian ducts - form female tract

Question 31

PCOS infertility treatment

Answer 31

clomiphene - estrogen receptor modulator - decreases negative feedback inhibition of gonadotropin from hypothalamus

Question 32

HER2/neu oncogene

Answer 32

encodes for intraceullar tyrosince kinase growth factor receptor

Question 33

polycythemia vera mutation

Answer 33

V617F mutation with JAK2 - increased marrow sensitivity to EPO and TPO

Question 34

theca interna cells

Answer 34

androgen synthesis - cholesterol to progesterone

Question 35

granulosa cell

Answer 35

aromatase - androgens to estrogen

Question 36

menopause marker

Answer 36

elevated FSH (no inhibition from estrogen)

Question 37

infundibulopelvic ligament

Answer 37

holds ovaries to lateral pelvic wall - contains ovarian vessels

Question 38

cardinal ligament

Answer 38

cervix to side wall of pelvis - contains uterine vessels

Question 39

desmolase

Answer 39

enzyme to convert cholesterol to androgens - theca cell

Question 40

arrest phase pre-ovulatoin

Answer 40

prophase I

Question 41

arrest phase pre-fertilization

Answer 41

metaphase II

Question 42

hCG production location

Answer 42

syncytiotrophoblast (outer layer of chorionic villi - low MHC I expression)

Question 43

spermatogenesis

Answer 43

spermatogonium (2N, 2C) –> primary spermatocyte (2N, 4C) –> secondary spermatocyte (1N, 2C) –> spermatid haploid (1N,1C) –> spermatozoon haploid (1N,1C)

Question 44

kallman syndrome

Answer 44

failure to complete puberty - hypogonadotropic hypogonandism - defective migration of GnRH cells and formation of olfactory bulbs - anosmia, infertility

Question 45

placental abruption

Answer 45

abrupt, painful bleeding - cocaine, HTN, smoking

Question 46

clear cell adenocarcinoma

Answer 46

DES exposure

Question 47

looks like bladder, solid pale yellowtan/encapsulated tumor - “coffee bean” nuclei

Answer 47

Brenner tumor - benign tumor of ovary

Question 48

meigs syndrome

Answer 48

triad of ovarian fibromas, ascites, hydrothorax - pulsing sensation in groin - spindle shaped fibroblasts

Question 49

serous cystadenocarcinoma

Answer 49

most common ovarian neoplasm - psammoma bodies

Question 50

adenomyosis treatment

Answer 50

GnRH agonists, hysterectomy

Question 51

leaf-like projections - large bulky mass of connective tissue/cysts

Answer 51

Phyllodes tumor - malignant potential

Question 52

small tumor in lactiferous ducts beneath areola - bloody nipple discharge

Answer 52

intraductal papilloma

Question 53

comedocarcinoma

Answer 53

DCIS with central necrosis

Question 54

Paget disease

Answer 54

from underlying DCIS - large cells in epidermis with clear halo

Question 55

lichen sclerosis

Answer 55

thinning of epidermis, fibrosis of dermis (parchment) - increased risk of SCC

Question 56

lichen simplex chronicus

Answer 56

hyperplasia of epithelium (thick leathery) - leukoplakia

Question 57

endometrial carcninoma

Answer 57

hyperplastic: estrogen exposure - endometrioid histo
sporadic: atrophic endometrium - serous/papillary/psammoma bodies

Question 58

leiomyosarcoma

Answer 58

malignant - single lesion in uterus w/ areas of necrosis/hemorrhage