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Step 1 > Flashcards - Path > Flashcards

Flashcards - Path

1
Q

fibrinoid necrosis

A

necrotic damage to vessel walls (fibrin complexes with immunoglobulins), pink - malignant hypertension, vasculitis, preeclampsia

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2
Q

intrinsic apoptosis

A

mitochondrial cytochrome C leaks when bcl-2 is inactivated (increased BAX); caspases induced by Apaf-1, bcl-2 inhibits Apaf-1

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3
Q

extrinsic apoptosis

A

FAS ligand binds with CD95 - activates caspases; TNF binds to TNF receptor - activates caspases

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4
Q

Anti-TNF risks

A

granumatous inflammation inhibition - tuberculosis

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5
Q

primary amyloidosis

A

deposits of Ig light chains - MM –> nephrotic syndrome, restrictive cardiomyopathy, hepatomegaly, neuropathy

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6
Q

secondary amyloidosis

A

serum amyloid A from chronic inflammation (IBD, RA)

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7
Q

P-glycoprotein

A

multidrug resistance protein - adrenal cell carcinoma - pumps out toxins/chemotherapeutics

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8
Q

arsenic

A

SCC of skin, lung cancer, angiosarcoma

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9
Q

napthylamine

A

urothelial carcinoma of bladder - in cigarette smoke

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10
Q

vinyl chloride

A

angiosarcoma of liver

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Step 1 (19 decks)

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