fisiopato Flashcards

1
Q

HLA diabetes 1

A

drb1 dqb1

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2
Q

hla 2 haolotipos que predisponen

A

dr4-dq8 y dr3-dq2

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3
Q

haplotipo protector

A

dr15-dq6

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4
Q

genes no hla

A

insulina cr11 ifih1 cr 2: respuesta contra virus

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5
Q

marcadores dqb

A

0302 0201 mayor riesgo 0302 0602 proteccion

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6
Q

Influencia del medio ambiente en dm2

A

60-90%

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7
Q

Mejor predictor para conversion de Itg a dm2

A

Aumento en el imc en el tiempo NO: glucosa ayuno o pp

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8
Q

triunvirato

A

menor secrecion menor captacion aumento glucogenesis hepatica

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9
Q

lugar donde disminuye la captacion de glucosa

A

musculo lo demas queda igual

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10
Q

octeto de fronzo

A

menos: insulina incretina captacion periferica de glucosa neuro trans maas: lipolisis, reabsorcion renal, gloconeogenesis hepatica , secrecion de glucagon

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11
Q

primera fase de secrecion insulina

A

detiene la produccion hepatica de glucosa y permite captacion hepatica y periferica si se tarda se prolonga la hiperglucemia representa las reservas

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12
Q

segunda fase sec insulina

A

permite al musculo y tejido adiposo captar glucosa compensadora

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13
Q

umbral en dm2

A

240 mgdl gliflozina baja el umbral

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14
Q

agonistas glp1

A

prevencion secundaria mortalidad cardiovascular

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