Final Review Flashcards
what are NTs of the AVS
acetycholine (efferent)
glutamate aspartate - excite AVS
gaba glycine - inhibit in AVS
what is a NT of the neuromuscular
acetycholine
Explain the process of stimulus all the way to synapsing of neurons
Neuron is sitting at resting membrane potential with all ion channels closed and inner voltage resting at -70 mV.
Outside trigger (like a spider brushing up against a knee, or a finger touching the hand) causes the mechanically gated ion channels (sodium channel) to open and sodium rushes in the membrane causing the cell to become depolarized
RP stays local where the stimulus was
RP are graded (amplitude modulated) signals with the amount of depolarization representing the strength of the signal.
Stimulus is strong enough to cause a threshold reach of the RP (about -55 mV)
AP (all or none, NO degradation, forward propagating, saltatory conduction)
at the axon hillock, Voltage-gated ion channels open at the first node of Ranvier and sodium rushes in, depolarizing that spot. Then the next (forward) node is stimulated and sodium rushes in so the AP propagates forward by saltatory conduction.
AP propagates down a neuron, activating sodium and potassium channels in a wave, it eventually reaches the presynaptic terminal
Reaching this terminal activates the voltage-gated calcium channels (Ca2+) to open and release calcium into the neuron’s cytoplasm (inside terminal bouton)
The flow of positively charged calcium ions causes the tiny synaptic vesicles (w/ NT) to fuse with the cell membrane and release those chemical messengers
these NT’s diffuse across the synaptic gap and bind to receptor sites on the postsynaptic neuron
Depending which NT binds to which receptor, the post neuron can either be excited or inhibited
correct order that they would occur during sensory transduction for a receptor in the skin and neuron of the ascending sensory pathway
Cell is at rest with a resting membrane potential of -65mV
2. Stimulus triggers a receptor potential
3. depolarization during the receptor potential initiates the action potential
4. Action potential reaches the terminal bouton and triggers synaptic transmission.
5. neurotransmitter is released into the synaptic cleft
purpose of the sodium potassium pump
for every two potassium ions that come in from the extracellular fluid ot the cytoplasm inside the membrane (pumps in), 3 sodium ions are pumped out
what cells create myelin in PNS & CNS
PNS - schwann cells, one axon per cell
CNS - oligodendrocytes, many axons
How does an AP encode intensity of a stimulus?
frequency modulation
a weak stimulus tends to trigger less frequency AP’s (like picking up an egg)
an intense stimulus increases the frequency of APs (like crushing a can)
explain 4 things of an AP
all or none, NO degradation, forward propagating, saltatory conduction)
Action potentials can be conducted along neurons quickly due the presence of myelin and saltatory conduction.
The AP can carry information over relatively long distances without degrading (without getting weaker) so it does not degenerate or lose information on its way to or from the brain
an action potential is all or none
Action potentials carry information about the stimulus as a frequency modulated signal with faster firing rates for stronger stimuli.
period when it cannot respond to any other stimulus no matter how strong (helps prevent signals from traveling in both directions down the axon at once)
absolute refractory period
where is A1
A1 is located on the transverse gyri of the superior temporal gyrus of the temporal lobe, inside the lateral fissure.
Describe Spiral ganglia and Scarpa’s ganglia
Scarpa’s -
The cell bodies of the bipolar afferent vestibular CN VIII fibers located in the internal auditory canal
Spiral ganglia - cochlea nuclei
what does ectoderm form
outer ear (skin) and inner ear (sense organs), membranous labyrinth
what does mesoderm form
ossicles, temporal bone and bony labyrinth
what does endoderm form
middle ear epithelial lining, aerated mastoid cavities, & ET
first sign outside of embryo that inner ear is forming?
otic cyst that invaginated from ectoderm and became inner ear
all 3 germ layers contribute
ME cavity - primordial structure that becomes middle ear
tubotympanic recess - tubo becomes ET, tympanic is the middle ear cavity
Which arches contribute to Ossicles?
1&2
how is outer ear/pinna formed
6 hillocks at 6 weeks that form this shape
how is the canal formed
form bw 1 & 2 arches
only opens later in development because it has meatal plug
how does the TM develop its 3 layers
from all 3 germ layers
ecto outside, meso in middle, endo in middle ear
During embryologic development, six hillocks of tissue form around both sides of the first branchial groove. What do these hillocks eventually become?
pinna of external ear
During embryological development of the central nervous system, which secondary vesicle of the neural tube becomes the pons, cerebellum and a portion of the fourth ventricle?
metencephalon
Which branchial arches play a major role in development of ear structures?
1&2
Embryologically, the central nervous system (including the brain and spinal cord), sense organs such as the cochlear and vestibular hair cells, and the skin are derived from which of the germ layers?
ectoderm
What is the generic term that describes defects of the spinal cord, during embryologic development when the caudal neuropore does not properly close?
spina bifida
With respect to neuroembryology, the term gastrulation refers to
Formation of the three primary germ layers
During embryologic development, which germ layer gives rise to the skeletal structures, circulation structures, meninges, and cartilage (including the ossicles and temporal bone)?
mesoderm
Embryologically, development of the inner ear begins with formation of…
The otic placodes which are thickenings of ectoderm
Embryologically, what structures are derived from the neural tube and its tissues?
Central nervous system structures including structures such as the cerebrum, brainstem, cerebellum, ventricles and spinal cord
During embryologic development, what does the tubotympanic recess eventually become?
middle ear space and ET
In the embryo, which flexure of the developing neural tube marks the location where the future brainstem meets the future spinal cord, and this bend straightens out over time during development?
cephalic flexure
Which branchial arches play a major role in development of ear/auditory structures?
1&2
where is regeneration more likely to happen in our body? PNS or CNS?
PNS
How does regeneration occur?
scwann tube of myelin is in tact and nerve regenerated, new sprout can find the path
attracted to muscle with loss of nerve innervation, grow extra achetecholine receptors and attach
schwann tube to guide the regrowth and attracted to acetecholine on receptors on the muscle to get regrowing nerve back to it causing successful regeneration in PNS
Which type of degeneration involves the distal portion of the axon that has been severed from the cell body and leaves Schwann tubes that may aid in regeneration?
orthograde degeneration
type of degeneration involving the distal portion of the axon that has been severed from the cell body and leaves Schwann tubes that may aid in regeneration
Orthograde degeneration
axonal degeneration occurs proximal to the site of injury -
retrograde degeneration
Loss of neurotrophic factors coming from the axon to the cell body
retrograde axoplasmic flow
nerve is cut and nerve degenerates, so now cell body creates more production and creates a growth cone and sends out sprouts., if it finds the schwann tube, it gets all the nutrients and regrows and reinnervates the muscle and the other sprouts dont go anywhere
regeneration
Main motor area located on the precentral gyrus with direct cortical control over motor neurons
M1
aids in preparation for motor movements through facilitating specific sets of primary motor neuronstate specific sets of neurons
PREMOTOR area
facilitates coordination of complex movements and is not needed for simple repetitive tasks
supplemental motor area
set of nuclei at base of cerebral hemispheres
basal ganglia
what makes up the basal ganglia
Putamen, caudate nucleus, globus pallidus, nucleus accumbens, and diencephalic subthalamic nuclei and substantia nigra
what is a group of BN called
striatum
what is the whole edge of putamen and GP called
lenticular nucleus
forms loop resulting in involvement in most cortical functions (movment, cognition, emotion)
feedback loop because it gets involved in many things
basal ganglia
spasms, involuntary movements of limbs or facial muscles, with possible hypotonia (loss of muscle tone)
chorea
characterized by excessive movement
hyperkinetic
characterized by diminished or slow movement
hypokinetic
“without position”; slow writhing movements (pronounced in hands and fingers); patient may have difficulty holding a limb in a fixed position
athetosis
“jumping about”; wild flailing movements of one arm and leg
ballismus
increased or abnormal tone in muscles or tissue resulting in a somewhat fixed posture
dystonia
loss of muscle tone
hypotonia
tone increase in flexors & extensors
rigidity
decreased or slow movements
bradykinesia
something new that showed up, something added that didn’t use to be there (tremor for ex)
positive signs
taking something away, used to be able to do something and now they cannot
negative signs
What is Huntingdon’s disease
movements that resembled “dancing” - chorea
Neuronal degeneration that is severe in the striatum and especially the caudate nucleus
autosomal dominant inherited disease
what is parkinson’s disease?
hypokinetic disorder
Biochemical disease of basal ganglia (evident in substantia nigra pigmented cells that should produce dopamine and transport it to the striatum)
more rigid and slow, non moving
have a tremor but if they pick up a coffee can and when they are moving the tremor goes away but when they are just sitting at rest, they have a tremor
what would be a positive and negative sign for Parkinson’s?
+ is rigidity
- is bradykinesia
major portion of inferior cerebellar peduncle (“ropelike”) with fibers from spinal cord and brainstem
restiform body
additional fibers of the ICP (inferior cerebellar peduncle) connecting cerebellum and vestibular nuclei
juxtarestiform body
largest peduncle and it emerges from the basal pons
middle cerebellar
peduncle that has many decussations and mainly efferent pathways from cerebellum to red nucleus and thalamus
superior cerebellar
Involved in equilibrium, control of muscle tone, posture and coordination of voluntary movements
cerebellum
what creates the dendritic tree seen in the cerebellar cortex
purkinje cells
difficulty with rapid alternating movements
dysdiadochokinesia
what would we see in damage to a child’s 4th ventricle?
Damage to flocculonodular lobe
Loss of equilibrium, sway side to side, staggering, wide-based gait, falling over, problems with eye movements, can also have noncommunicating hydrocephalus
what could we see with damage to cerebellum?
Can have changes in muscle tone (hypotonia), reflexes (hyporeflexia) and coordination of voluntary movements ipsi to side of lesion
Broad-based stagger, general incoordination or ataxia (“lack of order”), often in leg movements
Problems stopping or changing direction of movement (overshoot or undershoot of targets
dysmetria
Thin watery fluid anterior to the lens, between the lens and cornea
contains nutrients for cornea and lens
aqueous humor
does the cornea and lens have blood supply?
no, lacks this
aqueous humor provides nutrients for it
Thick, jelly-like semifluid found posterior to the lens, between the lens and the retina
Important for maintaining the shape of the eye/orbit
vitreous humor
white part of eye
sclera
clear portion of eye
nonadjustable “lens” of the eye
cornea
contains the blood vessels and nerves for the eye
choroid
pigmented portion and consists of smooth muscles for constricting and dilating the pupil
iris
Pupillary constriction is mediated by the parasympathetic component of
CN III
Dilation is mediated by sympathetic neurons from
spinal cord segments T1 and T2
suspended behind the iris by zonula fiber (thin guide ropes) that are anchored in the ciliary body
lens
contains involuntary muscles that vary the tension exerted on the lens by the zonula fibers
ciliary body
Adjusting the shape of the lens to make it more rounded is called
accomodation
what does accomodation of the eye help us do
Enables us to focus on near and far objects
light-sensing portion of the eye
retina
extension of the diencephalon
retina
are there multiple types of cells in teh retina?
yes, including bipolar
describe the retinogeniculostriate pathway
Retinal ganglion cells (getting information for receptors known as rods and cones)
CN II
Optic chiasm
Optic tract
Lateral geniculate nucleus of the thalamus
Internal capsule as thalamocortical projections
Optic radiations
Primary visual cortex (V1, Brodmann’s area 17, aka Striate cortex) either above or below the calcarine sulcus, in the cuneus or lingual gyrus respectively
represented in the occipital lobe in the left hemisphere
right visual field
represented in the occipital lobe in the right hemisphere.
left visual field
represented inferior to the calcarine sulcus (in the lingual gyrus)
upper visual field
represented superior to the calcarine (in the cuneus).
lower visual field
what does convergence of the eye help us do?
help both eyes look at the same object and focus
describe the light reflex
ganglion cells in retina pick light up, signal carried down CN 2 (optic), crosses the optic chiasm and optic tract to the lateral geniculate, then the superior colliculus stimulating the ciliary ganglion cells of CN 111 (occulomotor) to cause pupil constriction
do we need the cortex for light reflex?
NO
do we need the cortex for the acoustic reflex
no
is there cortical involvement for the accommodation convergences reflex
yes
how is the lens for distance vision
flattened
describe the accomodation convergence reflex
Adjustments of the lens by activation of the ciliary body to bring close objects into focus
There is cortical involvement
After stimulus info reaches the visual cortex, impulses descend from V1 to the superior colliculus to activate the preganglionic parasympathetic neurons of the Edinger-Westphal nucleus
Activation of the ciliary ganglion follows
To cause smooth muscles of the ciliary body to round the lens for near vision
Free nerve endings
Detecting stimuli that caused damage to tissue or that may cause damage
Nociceptors
What happens at the site of tissue damage
chemicals are released that cause dilation of arterioles—redness, leakage of plasma from venules—swelling, and attraction of phagocytes—cleaning up debris
inability to sweat and feel pain
CPA
if you are under stress, which part of ANS is active and what would it control
sympathetic, send harder pumping from heart to big muscles for ff response, reducing digestion and widening of eyes and stimulating sweat glands
Protective mechanism that is normal
Signaling tissue damage
Localized to the site of tissue damage
acute pain
Caused by inflammation, arthritis, nerve entrapment, gun shot wounds, surgery, migraine, cancer, spinal cord injury, stroke, tumors and more
chronic pain
pain located inside of our organs
ex: from gallstons, kidney stones, ulcers, etc.
visceral pain
Superficial pain is pain that arises from the skin (cutaneous receptors)
somatic pain
type of pain described by someone feeling pain in the chest wall or left arm when the stimulation is from the heart due to myocardial ischemia (a heart attack)
referred pain
pain that is projected to areas that are innervated by nerves that are compressed or damaged
With a shoulder injury, the pain may be projected to the wrist or elbow
projected pain
spontaneous pain that occurs in waves or sudden attacks following a noxious stimulus that has acted on the sensory neurons for a long period of time
Generally restricted to the regions supplied by the affected nerve or nerve root
neuralgia
what is trigeminal neuralgia
intractable facial pain along one or more branches of CN V
Maladaptive
from damage to nervous system that changes CNS connections
neuropathic/intractable pain
what kind of pain is phantom pain categorized as
neuropathic/intractable pain
direct stimulation of nociceptors
pain from pinpricks, cuts, minor burns etc
physiological pain (nociceptive)
what are the results of physiological pain
reflexive withdrawal away from the stimulus
Pain that is intensified by peripheral and central mechanisms helps to modify behavior to protect the affected areas during healing (like limping with a sprained ankle)
what is the gate theory
Developed in 1965 by Melzack and Wall
suggested there is a sort of “gate” in the dorsal horn of the spinal cord (specifically, in Rexed’s lamina II, the substantia gelatinosa) that either allows or does not allow pain transmission from afferents to the spinothalamic tract
can either enhance pain by fear and emotional status or we can inhibit this pain through our emotional status
Hitting the thumb with a hammer causes initial and delayed pain
Rubbing the thumb stimulates non-nociceptive cutaneous receptors and their afferents and helps to reduce the pain that is felt
gate theory
what is involved cortically with pain
Limbic system - These regions are thought to play a role in the affective response to painful stimuli
emotional response to pain - will we cry, will we get mad, what are we going to feel with that pain
cortex and frontal lobe also play a role in the affective response to pain - Evaluation of painful input in terms of past experience is also important in determining the response to painful input
lines the heart
endocardium
outermost layer of the heart
epicardium
middle muscular layer of heart
myocardium
what is endocarditis
an infection of the inner lining of the heart usually involving the heart valves
occurs when bacteria, fungi or other germs from another part of your body, such as your mouth, spread through your bloodstream and attach to damaged areas in heart.
has 3 leaflets, flow from left ventricle to the aorta and then to the body
prevents backflow
aortic semilunar valve
has 2 leaflets between left ventricle and atrium, flow from lungs into left atrium and then to left ventricle
between L atrium and L ventricle
mitral valve
has 3 leaflets, flow from right ventricle to pulmonary artery
pulmonary semilunar valve
3 leaflets, allows flow from right atrium to right ventricle,
tricuspid valve