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Neville and Damm > Fellowship MC > Flashcards

Fellowship MC Flashcards

1
Q

Metastases to the jaws bypassing filtration through the lungs occurs via the ?

A

Batson plexus

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2
Q

Following chemotherapy for leukemia a patient has a recurrence. What region of the body may still harbor neoplastic cells for recurrence and why?

A

Recurrence may spread from the brain because the blood brain barrier is not crossed by traditional chemotherapy agents

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3
Q

Metastatic disease to the jaw is typically via ______ spread

A

hematogenous

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4
Q

Location (s) of cleft in paraneoplastic pemphigus

A

subepithelial or intraepithelial

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5
Q

Location (s) of cleft in mucous membrane pemphigoid

A

subepithelial

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6
Q

Antibodies against ? are implicated in paraneoplastic pemphigus

A

plakin family of desmosomal components including periplakin and envoplakin (also sometimes desmoglein 1 &3)

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7
Q

What internal malignancy(ies) are most commonly associated with paraneoplastic pemphigus?

A

CLL, lymphoma

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8
Q

What is bronchiolitis obliterans

A

sloughing occuring in the bronchioles that can obstruct the airway, listed as a clinical feature of paraneoplastic pemphigus

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9
Q

Location (s) of cleft in angina bullosa hemorrhagica

A

subepithelial

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10
Q

Location (s) of cleft in epidermolysis bullosa acquisita

A

subepithelial

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11
Q

INheritance pattern of epidermolysis bullosa acquisita and autoantibodies implicated

A

Not inherited! (occurs in older adults)

autoantibodies to collagen type VII

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12
Q

Differentiate the DIF of MMP and epidermolysis bullosa acquisita

A

MMP: IgG C3 on the “roof” of the bullous lesion aka on the epithelial side
EBA: IgG deposits on the CT side of the bulla where the type VII collagen is

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13
Q

Location (s) of cleft in fogo selvage

A

fogo selvage aka endemic pemphigus foliaceus

intraepithelial clefting (IgG/C3)

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14
Q

Common feature of acanthosis nigricans and Leser-Trelat sign

A

Gastrointestinal malignancy

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15
Q

Inheritance pattern of hereditary mucoepithelial dyspasia

A

autosomal dominant or sporadic

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16
Q

Inheritance pattern for incontinentia pigmenti

A

X-linked dominant so female predominant disease

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17
Q

Location (s) of cleft in warty dyskeratoma

A

suprabasilar cleft

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18
Q

what is Papyraceous healing and what population does it occur in?

A

“crumpled cigarette paper” look to the skin after it heals in Ehlers Danlos, occurs with minor injury

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19
Q

Conditions with premature loss of teeth

A 
Sarcoidosis
hypophosphatasia
papillon-lefevre syndrome
Ehlers Danlos
Haim-Munk
Dentin dysplasia type 1
Swift-feer disease (Acrodynia)
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20
Q

Amianthoid fibers are characteristic of

A

myofibroblastoma aka intranodal hemorrhagic spindle cell tumor with amianthoid fibers

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21
Q

“tissue culture-like” and “feathery” growth describe

A

nodular fasciitis

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22
Q

pattern-less round to spindle proliferation describes

A

solitary fibrous tumor

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23
Q

Short intersecting fascicles aka storiform pattern describes

A

fibrous histiocytoma

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24
Q

Nodular or multinodular (lobular) fibroblastic proliferation decribes

A

myofibroma

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25
Q

What molecular test can be used to distinguish lipoblastoma from liposarcoma

A

lipoblastoma (occurs in infants) = recurrent rearrangement that includes PLAG1

26
Q

Cells of origin for CEOT

A

stratum intermedium aka rests of the dental lamina

27
Q

Entities that can originate from the rests of the dental lamina

A 
gingival cyst of the newborn
gingival cyst of the adult
LPC
Ameloblastoma (other things it can originate from too)
AOT
CEOT
SOT
OKC
28
Q

entities that can originate from the rests of Malassez

A

SOT

Periapical cyst/radicular

29
Q

The rests of malassez are derived from

A

hertwigs epithelial root sheath

30
Q

Infectious process resulting in a subcutaneous vascular proliferation recognized in patients with AIDS is termed? causative organism?

A

Bacillary angiomatosis

Bartonella henselae

31
Q

Most common cause of chronic regional LAD in children

A

Cat scratch disease

32
Q

Features of unicystic ameloblastoma

A

younger age group
90% in mandible, usually posterior
Classified with vickers gorlin criteria
treated with enucleation with only 10-20% recurrence

33
Q

EBV related malignancies

A

extranodal NK/T cell lymphoma, sinonasal type
Some nasopharyngeal carcinomas
Hodgkin lymphoma (significant # of cases)
Burkitt lymphoma
lymphomatoid granulomatosis
salivary lymphoepithelial carcinoma
Plasmablastic lymphoma

34
Q

Increased levels of serum alpha-fetoprotein are seen in?

A

hepatocellular carcinoma, ovarian cancer, germ cell tumor of the testes

35
Q

Hypertension, gross hematuria, fever, and Abdominal pain in a child may be indicative of?

A

Wilm’s tumor: most common kidney cancer in children

36
Q

What syndromes have Wilm’s tumor as a component

A

Beckwith weidemann
Hemifacial hyperplasia
Hyperparathyroidism jaw tumor syndrome

37
Q

Angiomyolipoma and cardiac rhabdomyoma are less common features of what condition?
-What are the major features of this condition?

A

Tuberous sclerosis
-Major: ash leaf spots, shagreen patches, facial angiofibromas, gingival fibromas, ungual and periungal fibromas, hamartomas of the CNS –> intellectual disability, seizures

38
Q

Primitive mesenchymal cells, cartilage, muscle, necrosis and foci of neuroepithelial differentiation describes

A

immature teratoma

39
Q

Most common malignant ovarian germ cell tumor
Female counterpart to testicular seminoma
Most common in children and young women
describes?

A

Dysgerminoma

40
Q

Biphasic, malignant tumor with high grade epithelial and sarcomatous components arising in the uterus describes what entity?

A

Malignant mixed mullerian tumor aka carcinosarcoma

41
Q

Most commonly used diagnostic test for systemic sclerosis

A

anticentromere antibodies

anti-Scl70

42
Q

Antibodies against periplakin and envoplakin

outside of neville: also desmoglein 3, epiplakin, BP230

A

Paraneoplastic pemphigus

43
Q

DIF continuous band of IgG and C3 localized to the basement membrane zone

A

Mucosal membrane pemphigoid

44
Q

DIF linear deposition of only IgA along the

basement membrane zone

A

IgA bullous dermatosis

45
Q

Most common CNS tumor

A

Glioma (includes astrocytoma, ependymoma, glioblastoma, oligodendroglioma and various subtypes / combinations)

46
Q

Most specific marker for wegner’s granulomatosis

A

c-ANCA (antineutrophil cytoplasm antibodies) aka PR3-ANCA

-less specific p-ANCA

47
Q

serum antinuclear antibodies are a non-specific marker that can be seen in what conditions

A

Lupus, chronic ulcerative stomatitis, sjogren syndrome, lupus like drug reactions

48
Q

Drugs for Crohns

A

mesalamine (5-aminosalicylic acid) or sulfasalazine

49
Q

What autoantibodies are implicated in chronic ulcerative stomatitis

A

autoantibodies against 70-kD nuclear protein (ΔNp63α,) an isoform of p63

50
Q

Commissural lip pits are associated with?

A

high incidence of preauricular pits

51
Q

A layer of balloon cells just beneath the keratin layer in a biopsy is characteristic of?

A

Oral hairy leukoplakia

52
Q

Hypochromic microcytic anemia is a finding of

A

Iron deficiency anemia

also plummer vinson which is just syndrome with iron def anemia

53
Q

inability of the stomach to form intrinsic factor describes what disease

A

Pernicious anemia

54
Q

Megaloblastic/Macrocytic anemia occurs in what conditions

A

Pernicious anemia
VitB12 def
Folate deficiency

55
Q

Malignant epithelial cells have an increased number and wider distribution of what receptor?

A

Laminin

56
Q

biphasic cell population represented by peripheral large, polygonal, clear cells and central cuboidal darkly staining cells with eosinophilic cytoplasm describes?

A

epithelial myoepithelial carcinoma

57
Q

Oral bisphosphonates

A

Fosamax (alendronate)
Actonel (risedronate)
Boniva (ibandronate)

58
Q

IV bisphosphonates

A

Zometa (zolendronate)

Aredia (pamidronate)

59
Q

A patient presents with HHT, they have apparent telangiectasias of the oral cavity and facial skin. What other manifestations of this disease may affect your management?

A
  • recurrent spontaneous epistaxis
  • AV malformations of lungs, liver, CNS
  • Rupture of vascular lesions in the GI frequently causes iron deficiency anemia
60
Q

DDX large verrucous lesion of the buccal mucosa present for 6 months

A

Verrucous carcinoma
SCC
PVL
Verruca vulgaris

61
Q

Serologic tests for mono

A
  • Paul-Bunnell test OR rapid slide agglutination (Monospot) assay. Both look for heterophile antibodies
  • indirect immunofluorescence for viral capsid antigens and EBV nuclear antigens
62
Q

tender, inflamed, hemorrhagic gingiva with little response to oral hygiene for 2 month duration DDX (4)

A

Leukemic infiltrate
Wegners granulomatosis
scurvy
plasma cell gingivitis

Neville and Damm (72 decks)

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