Ch5 Bacteria (Gonorrhoeae thru Leprosy) Flashcards

1
Q

What is the most common reportable bacterial infection in the United States?

A

Neisseria Gonorrhoeae

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2
Q

Gonorrhea: sexual contact (genital areas) Indirect infection is rare (because of _____ and cannot
penetrate intact stratified squamous epithelium). incubation = ________. Affected areas often demonstrate significant ______ discharge, but 10% men and 80% women are ASYMPTOMATIC

A

drying…2 to 5 days…purulent

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3
Q

75% of patients with disseminated gonorrhea = characteristic skin rash develops…what do they look like? Here are they found?

A

Papules and pustules that often exhibit a hemorrhagic component and occur primarily on the extremities

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4
Q

Oral cavity gonorrhea can mimic ______, but what is ONE KEY difference?

A

NUG…LACK OF FETOR ORIS (bad smell)

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5
Q

What is the term for when gonorrhea is spread to the eye during birth of a child?

A

Gonococcal opthalmia neonatorum

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6
Q

What is the gram for neisseria gonorrhoeae? Whats the morphology?

A

gram negative diplococcus

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7
Q

What is the most common coinfection with gonorrhea?

A

chlamydia trachomatis

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8
Q

What is the first line treatment for gonorrhea?

A

IM CEF-TRI-AXONE + azithromycin or doxycycline

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9
Q

What is the estimate for amount of the world population infected with TB?

A

ONE FUCKING THIRD :-O (2 buh-buh-billion)

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10
Q

What are two other mycobacterium besides TB that cause infection?

A

mycobacterium bovis and mycobacterium avium-intracellulare

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11
Q

Besides HIV-infected individuals, how do MOST other cases of NON-TB mycobacterial infections present?

A

localized chronic cervical LAD in otherwise healthy children

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12
Q

What flavor of mycobacterium is most common as an opportunisitic infection in HIV+ pts?

A

Mycobacterium avium-intracellulare

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13
Q

Primary TB is in previously UNEXPOSED pts and ALMOST ALWAYS involves what organ?

A

lungs

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14
Q

What % of patients with TB progress from infection to ACTIVE DISEASE?

A

ONLY 5-10% (usually in immunocompromised)

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15
Q

What is another name for SECONDARY TB? (reactivation of the bug)

A

Miliary TB (resembles millet seeds)

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16
Q

Primary TB is usually ASYMPTOMATIC, but what two symptoms are most likely to occur if symptomatic?

A

fever and pleural effusions

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17
Q

Classically the lesions of secondary TB are located in WHAT REGION of the lungs?

A

APEX

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18
Q

What is the term for TB involvement of the skin?

A

Lupus Vulgaris

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19
Q

What are the three most common head & neck sites for extrapulmonary TB?

A

Cervical lymph nodes, larynx, and middle ear

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20
Q

What are the most common presentations of oral TB? (rare)

A

chronic ulcers or swellings

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21
Q

Because TB can have ulcerations in the mouth and palpable lymph nodes, what is also on the differential?

A

SCC

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22
Q

What is the reported prevalence of oral TB lesions? What are the 2 proposed methods of how pulmonary TB would move to the oral cavity?

A

0.5 - 5% of TB cases have oral manifestations….1) hematogenous spread vs 2) exposure to infected sputum

23
Q

Primary oral TB WITHOUT pulmonary involvement is RARE…what AGE group is more likely to have this?

A

children / adolescents

24
Q

What is the name for a (nonTB) mycobacterial infection obtained from drinking contaminated milk? What are the clinical features? What is a radiographic feature?

A

SCROFULA…enlargment of OROPHARYNGEAL lymphoid tissues and CERVICAL lymph nodes…radio: calcification of the lymph nodes

25
What type of giant cell is seen in a TB granuloma?
Langhans (nuclei around the rim)
26
What is the term for a TB granuloma (besides caseating/necrotizing)?
tubercle
27
What % of special stains for TB will actually be positive? What is the newer fluorescence microscopy technique called?
27-60%....Auramine-rhodamine stains
28
What does PPD stand for in the PPD TB skin test?
purified protein derivative
29
Culturing of TB from a patient is recommended for diagnosis. How long does this take?
4 to 6 weeks may be required to identify the organism in culture
30
What are the 6 TB meds?
PRIEST: pyrazinamide, rifampin, isonazid, ethambutol (not listed in Neville: Streptomycin, T?)
31
What is the name of the vaccine used for positive PPD tests? (given in 85% of the world, but not in US due to controversy of its effectivness)
BCG vaccine (Bacilus Clamette-Guerin)
32
What is the bug responsible for LEPROSY?
Mycobacterium LEPRAE
33
Where is leprosy thought to first enter the body?
nasal or oropharyngeal mucosa
34
Why does leprosy choose to live in the skin, nasal cavity, and the palate?
they need a COOL environment
35
In patients with a high immune reaction to leprosy, what is the term?
tuberculoid leprosy
36
Which form of leprosy?? Typically, the organisms are not found in skin biopsy specimens, skin test results to heat-killed organisms (LEPROMIN) are positive, and the disease usually is localized.
Tuberculoid leprosy
37
In patients with a LOW immune response to leprosy, what is the term?
Lepromatous leprosy
38
Which form of leprosy?? These patients exhibit numerous organisms in the tissue, do not respond to lepromin, and have diffuse disease..
Lepromatous leprosy
39
What are the 5 categories of leprosy infection?
``` Tuberculoid leprosy Lepromatous leprosy borderline-tuberculoid borderline-borderline borderline-lepromatous ```
40
Woah, what are the incubation periods for tuberculoid and lepromatous leprosy?
2-5 years for tuberculoid, 8-12 years for lepromatous
41
_______ leprosy exhibits a small number of well-circumscribed, hypopigmented skin lesions. Nerve involvement usually results in anesthesia of the affected skin, often accompanied by a loss of sweating.
tuberculoid (paucibacillary)
42
_______ leprosy begins slowly with numerous, illdefined, hypopigmented macules or papules on the skin that, with time, become thickened
Lepromatous (multibacillary)
43
Lepromatous leprosy commonly involves the face and produce enlargements and distort the face, called _______
leonine facies
44
COLLAPSE OF THE BRIDGE OF THE NOSE IS PATHOGNOMONIC for ?
lepromatous leprosy
45
Leprosy can cause MACROCHEILIA which can be confused clinically and microscopically with ?
cheilitis granulomatosa
46
What are the TRIAD of lesions in FACIES LEPROSA?
1.atrophy of the anterior nasal spine 2. atrophy of the anterior maxillary alveolar ridge 3. endonasal inflammatory changes
47
What color can the crowns of infected leprosy teeth be in children?
red
48
What is one of the most treatable causes of neuropathy in the world?
neuropathy caused by leprosy
49
Lepromatous leprosy demonstrates no well-formed granulomas; the typical finding is sheets of lymphocytes intermixed with vacuolated histiocytes known as ______ cells
LEPRA
50
Which form of leprosy will show an abundance of organisms on histology? Which will show little or none?
Lepromotous = LOTS, tuberculoid = little
51
Can you culture M. Leprae in culture?
Nope. ID'd by molecular techniques tho
52
What three abx are given for multibacilliary (lepromatous) leprosy?
(RCD) Rifampicin, Clofazimine, Dapsone
53
What two abx are given for paucibacilliary (tuberculoid) leprosy?
Rifampicin, dapsone
54
What are the three animals associated with being hosts for mycobacterium leprae?
armadillos, chimpanzee, mangabey monkey