Ch10 Genes

Question 1

Multifocal epithelial hyperplasia (Heck Disease)…also which HPV strains?

Answer 1

HLA-DR4 allele…13 and 32

Question 2

Verruciform xanthoma (cutaneous)

Answer 2

3-beta-hydroxysteriod dehydrogenase (somatic mutation)

Question 3

Seborrheic Keratosis. What inheritance pattern?

Answer 3

FGFR3 and PIK3CA….AD

Question 4

Ephelis (freckle). What inheritance pattern?

Answer 4

MC1R..AD

Question 5

Actinic Lentigo

Answer 5

FGFR3 and PIK3CA

Question 6

Acquired melanocytic nevus (mole)

Answer 6

BRAF

Question 7

Spitz nevus

Answer 7

HRAS

Question 8

Melanoma (7)

Answer 8

CDKN2A, CDK4, MC1R, BRAF, KIT (mucosal melanoma), MAPK, PI3K/AKT

Question 9

Blue Nevus

Answer 9

GNAQ (rarely BRAF)

Question 10

Chromosomes associated with risk of malignant transformation of leukoplakia

Answer 10

Loss of heterozygosity 3p and 9p

Question 11

Actinic keratosis

Answer 11

TP53

Question 12

HPV associated squamous cell carcinoma (5)

Answer 12

E6 (degrades p53) and E7 (inactivates pRb), increased p16, WTp53

Question 13

Oral SCC (7)

Answer 13

RAS, MYC, EGFR, TP53, pRb, p16, E-cadherin

Question 14

Nuclear protein in testis midline carcinoma

Answer 14

NUT chromosome 15q14

Question 15

Basal Cell Carcinoma (3)

Answer 15

PTCH (“patched”), SMO (“smoothened”), TP53

Question 16

Congenital Nevus

Answer 16

NRAS