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FA Haematology Flashcards

1
Q

How do platelets bind to vwf

A

GP1b

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2
Q

PT measures

A

Extrinsic

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3
Q

PTT measures

A

Intrinsic

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4
Q

Warfarin monitor

A

PT (affects both but 7 has shortest half-life)

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5
Q

What synthesizes vit K?

A

Enteric bacteria

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6
Q

How do clotting factors get activated

A

Gamma carboxylation

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7
Q

DOAC reversal

A

Andexanet alfa

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8
Q

tPA can cause

A

Angiooedema

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9
Q

Heparin reversal

A

Protamine sulphate

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10
Q

Dabgatrin reversal

A

Idarucizumab

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11
Q

Inhibits epoxide reductase

A

Warfarin

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12
Q

Doac vs warfarin metabolism

A

Renal, hepatic

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13
Q

INR monitoring

A

> 10 - stop and give vit k
4.5 - 10 - hold and can give vit k
<4.5 - hold next dose and then go to maintenance (adjust)

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14
Q

What blood replacement product has high concentration of fibrinogen, VIII, vWF

A

Cryoprecipitate

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15
Q

Who gets haemophilia C?

A

Ashkenazi Jewish

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16
Q

Best source of factor 8 and fibrinogen?

A

Cryo
FFP also has

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17
Q

Heyde syndrome

A

Aortic stenosis, GI bleeding, acquired vWD

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18
Q

Diagnosis of vWD

A

Reduced agglitination on Ristocetin

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19
Q

Most common inherited bleeding disorder

A

vWD

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20
Q

Treat vWD

A

Desmopressin, antifibrinolytic

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21
Q

Provoked DVT treatmentt

A

3-6 months
Lifelong if more

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22
Q

DVT but anticoagulant is contraindicated

A

IVC filters

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23
Q

Protein C deficiency causes

A

Skin necrosis with warfarin administration

24
Q

APS effects

A

Coagulation defects
Livedo reticularis
Obstetric comp
Thrombocytopenia
SLE

25
Q

Does DIC have haemorrhage or thrombosis?

26
Q

Antibodies in APS

A

Lupus anticoagulant
Beta 2 glycoprotein
Cardiolipin

27
Q

TTP treatment

A

Plasma exchange, steroids

28
Q

Fibrinogen TTP, HUS, DIC

A

Only affected in DIC (low)

29
Q

What is wrong on labs in VWD

A

only increased bleeding (can affect PTT because of factor 8)

30
Q

What is ITP?

A

IgG against membrane protein G2b/3a

31
Q

Treat ITP

A

<30,000 or bleeding = steroids, IVIg

32
Q

Haemolytic vs non-haemolytic anaemia

A

Reticulocyte (increased vs decreased)

33
Q

Microcytic anaemias can be split into

A

Defect harm (iron def. lead poison, sideroblastic, acd) and global (thalassemia)

34
Q

Non-megaloblastic macrocytic

A

Liver
Alcohol

35
Q

Most accurate IDA test?

A

Prussian blue bone barrow stain

36
Q

Does thalassemia anaemia respond to iron ?

37
Q

Lead lines aka

A

Burton lines

38
Q

What TB drug can cause sideroblastic anaemia?

39
Q

Microcytic anaemia where serum iron is elevated

A

Sideroblastic

40
Q

HbH

41
Q

Hb Barts

42
Q

Warm AIHA

A

IgG
SLE, CLL, penicillin, rifampicin, phenytoin, methyldopa

43
Q

Cold AIHA

A

IgM
Myocoplasma
EBV
Waldenstrom

44
Q

B12 can be caused by

A

Diphyllobothrium lactum

45
Q

Phenytoin use causeswhat deficiency

A

Folate deficiency

46
Q

Felty

A

Neutropenia
Splenomegaly
RA

47
Q

ABPA diagnosis

A

IGE against A fumingatus

48
Q

Leukaemia most accurate test

A

Bone marrow biopsy with flow cytometry

49
Q

Non-hodgkin vs hodgkin cells

A

Mainly B
Reed Sternberg

50
Q

Alcohol induced lymph node pain

A

Hodgkins lymphoma

51
Q

Dutcher bodies

A

Wallenstrom

52
Q

AL amyloid

A

MM Waldenstrom

53
Q

AA amyloid

A

RA, inflammatory

54
Q

Transplant between twins

55
Q

Allogeneic

A

Donor to genetically different patient

56
Q

GVHD affects

A

Skin, GI, liver, lung

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