FA Haematology Flashcards
How do platelets bind to vwf
GP1b
PT measures
Extrinsic
PTT measures
Intrinsic
Warfarin monitor
PT (affects both but 7 has shortest half-life)
What synthesizes vit K?
Enteric bacteria
How do clotting factors get activated
Gamma carboxylation
DOAC reversal
Andexanet alfa
tPA can cause
Angiooedema
Heparin reversal
Protamine sulphate
Dabgatrin reversal
Idarucizumab
Inhibits epoxide reductase
Warfarin
Doac vs warfarin metabolism
Renal, hepatic
INR monitoring
> 10 - stop and give vit k
4.5 - 10 - hold and can give vit k
<4.5 - hold next dose and then go to maintenance (adjust)
What blood replacement product has high concentration of fibrinogen, VIII, vWF
Cryoprecipitate
Who gets haemophilia C?
Ashkenazi Jewish
Best source of factor 8 and fibrinogen?
Cryo
FFP also has
Heyde syndrome
Aortic stenosis, GI bleeding, acquired vWD
Diagnosis of vWD
Reduced agglitination on Ristocetin
Most common inherited bleeding disorder
vWD
Treat vWD
Desmopressin, antifibrinolytic
Provoked DVT treatmentt
3-6 months
Lifelong if more
DVT but anticoagulant is contraindicated
IVC filters