Allergy and Immunology

Question 1

CVID

Answer 1

Dysfunctioning B cells, low output
Normal T cells
Low IgG, sometimes low IgM IgA
Recurrent sinopulmonary infections
Normal amount of lymphoid tissue

Question 2

Bruton agammaglobulinemia

Answer 2

X-linked
Male kids
Sinopulmonary, similar to CVID but diminished lymphoid tiossues
FLOW CYTOMETRY OF PERIPHERAL TISSUES
decreased response to vaccines

Question 3

SCID

Answer 3

Decreased B and T cells
Presents similarly to AIDS
Treatment is bone marrow transplant

Question 4

IgA deficiency

Answer 4

Anaphylaxis
Allergy/atopy

Question 5

Wiskott Aldrich syndrome

Answer 5

Low T cells
Thrombocytopenia
Eczema
Normal B cells
Bone marrow transplnat

Question 6

LAD

Answer 6

Massively elevated WBC count
Soft tissue infections without pus
Decreased CD18 on neutrophils

Question 7

DiGeorge syndrome

Answer 7

Low T cells

Question 8

Chediak-Higashi syndrome

Answer 8

Neutropenia, bactericidal dysfunction, serotonin and platelet defect
Albinism and staph infections

Question 9

Hyper IgE syndrome

Answer 9

Infection with staph (skin infections)
Eosinophilia

Question 10

Chronic granulomatous disease

Answer 10

Lymph nodes with purulent material
Infections with atypical organisms
Oxidative burst test
impaired superoxide
TMX
Itraconazole

Question 11

Malignancy, increased infection, Low IgG, IgM, IgA, T cells

Answer 11

Ataxia-telangiectasia

Question 12

Test for CGD

Answer 12

Dihidorrhodamine test