Exercise 06: Cholinergic Agonists and Antagonists

Question 1

Two (2) Drugs Samples Used in this Exercise

Answer 1

1. Pilocarpine Hydrochloride
2. Atropine Sulfate

Question 2

Constricted (Miosis) pupil after the application of __________ ophthalmic solution.

Answer 2

Pilocarpine

Question 3

Dilated (Mydriasis) pupil after the application of __________ ophthalmic solution.

Answer 3

Atropine

Question 4

Cholinergic Agonist

Answer 4

Pilocarpine

Question 5

From the Leaves of Pilocarpus jaborandi. Action: Muscarinic Action similar to Ach. It can be use for Glaucoma (Narrow and Open Angle / Close and Wide Angle). It stimulates M3 in the Pupil Miosis → Drains Aqueous Humor and Decreases Ocular Pressure.

Answer 5

Pilocarpine

Question 6

(T/F): Pilocarpine is extremely effective in opening the trabecular meshwork around Schlemm’s canal, causing an immediate drop in intraocular pressure as a result of the increased drainage of aqueous humor. This action occurs within a few minutes, lasts 4 to 8 hours, and can be repeated.

Answer 6

T

Question 7

Cholinergic Antagonist

Answer 7

Atropine

Question 8

Found in Atropa belladonna or deadly night shade or in Datura stramonium or jimsonweed (Jamestown weed) or thorn apple. It causes reversible blockade of cholinomimetic actions at muscarinic receptors. When it binds to the muscarinic receptor, it prevents the actions of muscarinic agonists such as the release of IP3 & the inhibition of adenylyl cyclase.

Answer 8

Atropine

Question 9

Atropine Poisoning

Answer 9

Reverse of Dumbbells

Question 10

Reverse of Dumbbells

Answer 10

• Dry Mouth, Mydriasis
• Tachycardia, Hot, and Flushed Skin
• Agitation, Delirium