Drugs for Coagulative Disorders (Part 02)

Question 1

Anticlotting Drugs

Answer 1

1. Anticoagulants
2. Antiplatelets
3. Thrombolytics

Question 2

It is used to prevent the formation of clots.

Answer 2

Anticoagulants

Question 3

It is used to inhibit platelet aggregation.

Answer 3

Antiplatelets

Question 4

It is used to dissolve such life-threatening clots.

Answer 4

Thrombolytics

Question 5

Drug/s that Facilitate Clotting

Answer 5

Hemostatics

Question 6

It is used to speed clot formation, or to limit bleeding from surgical site.

Answer 6

Hemostatics

Question 7

It is used to prevent the formation and enlargement of clots.

Answer 7

Anticoagulants

Question 8

Example/s of Anticoagulants

Answer 8

• Warfarin (Coumadin)
• Heparin
• Low Molecular Weight Heparin

Question 9

Action/s of Anticoagulants

Answer 9

• Inhibit certain clotting factors.
• Lengthen clotting time.
• Prevent thrombi from forming or growing larger.

Question 10

Its MOA is to inhibit Vitamin K Synthesis

Answer 10

Warfarin

Question 11

Its MOA is to activate Antithrombin III

Answer 11

Heparin

Question 12

Oral or IV

(Warfarin or Heparin)

Answer 12

Warfarin

Question 13

IV or SC

(Warfarin or Heparin)

Answer 13

Heparin

Question 14

PT-INR

(Warfarin or Heparin)

Answer 14

Warfarin

Question 15

APTT

(Warfarin or Heparin)

Answer 15

Heparin

Question 16

Prophylactic for Acute MI

Answer 16

Warfarin

Question 17

Prevention of Venous Thrombosis

Answer 17

Heparin

Question 18

Antidote for Warfarin

Answer 18

Vitamin K

Question 19

Antidote for Heparin

Answer 19

Protamine Sulfate

Question 20

Other Name of Vitamin K

Answer 20

Antihemorrhagic Factor

Question 21

Vitamin K-1
Vitamin K-2
Vitamin K-3

Answer 21

Phylloquinone
Menaquinone
Menadiol

Question 22

Drug/s under LMWH

Answer 22

• Enoxaparin (Lovenox)
• Tinzaparin (Fragmin)
• Dalteparin (Innohep)

Question 23

Anticoagulants of choice for treating pregnant women with prosthetic heart valves or venous thromboembolism.

Answer 23

• Enoxaparin (Lovenox)
• Tinzaparin (Fragmin)
• Dalteparin (Innohep)

Question 24

Anticoagulants under Direct Thrombin Inhibitors

Answer 24

1. Lepirudin (Refludan)
2. Argatroban
3. Fondaparinux (Arixtra)

Question 25

Polypeptide that is closely related to hirudin.

Answer 25

Lepirudin (Refludan)

Question 26

Prophylactic for the treatment of thrombosis in patients with HIT.

Answer 26

Argatroban

Question 27

First in new class of pentasaccharide anticoagulants that is purely synthetic.

Answer 27

Fondaparinux (Arixtra)

Question 28

Most common and potentially serious adverse effect is bleeding.

Answer 28

Anticoagulants

Question 29

Most common and potentially serious adverse effect is bleeding.

Answer 29

Anticoagulants

Question 30

Anticoagulants under Indirect Thrombin Inhibitors

Answer 30

• Warfarin (Coumadin) • Heparin • Low Molecular Weight Heparin

Question 31

Four (4) Primary Subclasses of Antiplatelets

Answer 31

1. Aspirin (Acetylsalicylic Acid) 2. ADP Receptor Blockers 3. Glycoprotein IIA/IIB Receptor Blockers 4. PDE Inhibitors

Question 32

Irreversible inhibition of COX.

Answer 32

Aspirin (Acetylsalicylic Acid)

Question 33

Prophylactic for transient cerebral ischemia and to reduce the incidence of recurrent MI.

Answer 33

Aspirin (Acetylsalicylic Acid)

Question 34

A/E of Aspirin (Acetylsalicylic Acid)

Answer 34

1. Increased Incidence of Hemorrhagic Stroke 2. GIT Bleeding 3. Salicylism = Tinnitus

Question 35

It is also known as Thienopyridines.

Answer 35

ADP Receptor Blockers

Question 36

Irreversibly inhibit the binding of ADP to its receptors on platelets.

Answer 36

ADP Receptor Blockers

Question 37

Drug/s under ADP Receptor Blockers

Answer 37

• Clopidogrel (Plavix) • Ticlopidine (Ticlid) • Prasugrel (Effient)

Question 38

It is the preferred agent in ischemic heart disease events.

Answer 38

Clopidogrel (Plavix)

Question 39

It causes Neutropenia / Agranulocytosis, Thrombotic Thrombocytopenic Purpura (TTP), and Aplastic Anemia.

Answer 39

Ticlopidine (Ticlid)

Question 40

Drug/s under Glycoprotein IIA and IIB Blockers

Answer 40

1. Abciximab (Reopro) 2. Eptifibatide (Integrilin) 3. Tirofiban (Aggrastat)

Question 41

A chimeric monoclonal antibody.

Answer 41

Abciximab (Reopro)

Question 42

Drug/s under PDE Inhibitor

Answer 42

Dipyridamole

Question 43

It is usually given in combination with aspirin or warfarin; it is ineffective when used alone.

Answer 43

Dipyridamole

Question 44

Used to dissolve existing clots.

Answer 44

Thromobolytics

Question 45

Three (3) Types of Thrombolytics

Answer 45

1. Streptokinase (Streptase) 2. Tissue Plasminogen Activator 3. Anistreplase

Question 46

Protein from Streptococci

Answer 46

Streptokinase (Streptase)

Question 47

Derived from Cultured Human Melanoma Cells

Answer 47

Tissue Plasminogen Activator

Question 48

Anisoylated Plasminogen Streptokinase Activator Complex

Answer 48

Anistreplase

Question 49

Used to promote the formation of clots.

Answer 49

Hemostatics

Question 50

Drug/s under Hemostatics

Answer 50

1. Aminocaproic and Tranexamic Acid (Hemostan) 2. Aprotinin 3. Desmopressin Acetate

Question 51

Inhibit Plasminogen Activation

Answer 51

Aminocaproic and Tranexamic Acid (Hemostan)

Question 52

Potential S/E of Treatment is Intravascular Thrombosis

Answer 52

Aminocaproic and Tranexamic Acid (Hemostan)

Question 53

It stops bleeding by blocking plasmin.

Answer 53

Aprotinin

Question 54

Approved for prophylactic use to reduce perioperative blood loss and the need for blood transfusion in patients undergoing cardiopulmonary bypass sugery.

Answer 54

Aprotinin

Question 55

This is the vasopressin V2 receptor agonist that increases the plasma concentration of von willebrand factor and factor VIII.

Answer 55

Desmopressin Acetate