Excitatory and Inhibitory Neurotransmission Flashcards
What is the typical resting membrane potential for a neuron?
-70mV
Is it the depolarization of repolarization of neurones that causes the release of neurotransmitter substances?
Depolarization
Does opening of sodium channels cause excitation or inhibition?
Excitation. Sodium flows inwards and causes depolarizaion
Give an example of a drug that is a Na+ channel antagonist
Lidocaine
At the synapse what channel is opened in response to depolarization?
Voltage activated calcium channels
At the synapse, what does the influx of calcium cause?
Exocytosis of synaptic vesicle contents.
Where are ionotropic receptors most often found?
Skeletal muscle
In glutamate mostly an excitatory or inhibitory neurotransmitter?
Excitatory
What is an ionotropic receptor?
The receptor is an integral component of the molecules that forms the channel in controls (direct gating)
What is a metabotropic receptor?
The receptor and the channel is controls are distinct; indirect gating.
Do NMDA receptors have a high or low permeability to Ca+?
High
Which receptor has a faster action; ionotropic or metabotopic?
Ionotropic
Which receptor acts as a synaptic modulator (slows down neurotransmitter release); ionotropic or metabotropic?
Metabotropic
Which receptor is a nicotinic receptor; ionotropic or metabotopic?
ionotropic
Which receptor is a G protein coupled receptor; ionotropic or metabotropic?
Metabotropic
