Exam Three Online Part One

Question 1

what sequence is where epigenetic regulation typically occurs
ApT
GpC
UpC
CpG

Answer 1

CpG

Question 2

imprinting is caused by sex-specific methylation
true/false

Answer 2

true

Question 3

cell division by mitosis usually resects the genome by wiping out methylation patterns
true/false

Answer 3

false

Question 4

angelman syndrome is a loss of function disease where the paternal chromosome is imprinted
true/false

Answer 4

true

Question 5

there are multiple origins of replication within each human chromosome
true/false

Answer 5

true

Question 6

telomerase is found in all cells
true/false

Answer 6

true

Question 7

activators can lead to chromatin remodeling
true/false

Answer 7

true

Question 8

transmission of organelle-encoded traits is usually uniparental
true/false

Answer 8

true

Question 9

ChIPSeq is used to determine the amino acid sequence of chunks of proteins
true/false

Answer 9

false

Question 10

DNA polymerase would be considered a housekeeping gene
true/false

Answer 10

true

Question 11

interrupted mating or cotransduction experiments can demonstrate the order of genes on a bacterial chromosome
true/false

Answer 11

true

Question 12

in a gain of function disease like Huntington gene therapy with a gene coding for mRNA could be a useful approach to treatment
true/false

Answer 12

true

Question 13

DNA folding has no role in regulation of gene expression
true/false

Answer 13

false

Question 14

alternative sigma factors can mediate the bacterias response to its environment
true/false

Answer 14

true

Question 15

transcription factors generally bind as dimers or multidimers
true/false

Answer 15

true

Question 16

mRNA is a type of RNAi that increases transcript levels
true/false

Answer 16

false

Question 17

eukaryotic genes are regulated by fewer proteins than are those in a prokaryote
true/false

Answer 17

false

Question 18

an enhancer is a cis acting element that may interact with a trans acting element
true/false

Answer 18

true

Question 19

histones can participate in the regulation of gene expression in bacteria
true/false

Answer 19

false

Question 20

eukaryotic activators are also called transcription factors
true/false

Answer 20

true

Question 21

methylation usually occurs at what sites on your DNA?

Answer 21

cytosine bases

Question 22

parent specific silencing of genes is called ___, and an example of a disease inherited in this manner would be ___

Answer 22

imprinting
Angelmans syndrome

Question 23

a group of structural genes in bacteria with a common function and under the control of a common promoter is called an ___

Answer 23

operon

Question 24

in catabolite repression of the lac and other operons, the activity of the CRP protein depends on what small molecule binding to it?

Answer 24

cAMP

Question 25

about what % of your total genes code for transcription factors?

Answer 25

10%

Question 26

what are two examples of post-translational protein modifications?

Question 27

what 2 domains do all transcription factors have on them?

Answer 27

DNA binding and activation

Question 28

give an example of a domain protein that binds to DNA

Answer 28

helix turn helix

Question 29

what is the difference between the lytic and lysogenic cycles of a virus

Answer 29

the lytic cycle does not allow the virus DNA to integrate into the human genome, but the lysogenic cycle does

Question 30

list at least 5 levels of control of gene expression in eukaryotes

Answer 30

transcription, translation, post transcription, post translation, epigenetics

Question 31

how do you use a reporter gene (and give example) to see how a gene is regulated?

Answer 31

they identify enhancers, GFP

Question 32

describe or illustrate the 2 mechanisms regulating the trp operon in bacteria

Question 33

what's the difference between a riboswitch and a ribozyme

Answer 33

a riboswitch is a type of ribozyme that regulates transcription and translation