Exam 3 - Respiratory Flashcards
VC
TV + ERV + IRV
IC
TV + IRV
FRC
ERV + RV
TLC
TV + ERV + IRV + RV
Inspiration
external intercostal and diaphragm contraction
Expiration
internal intercostal and abdominal contraction
Shift Right
Reduced affinity for O2, release O2, High Temp, High H+/CO2, low pH, High 2,3-BPG (activity)
Shift Left
Increased affinity, Decreased Temp, Decreased H+/CO2, Increased pH, Decreased 2,3-BPG (non-active)
Type 1 Alveolar Cells
exchange
Type 2 Alveolar Cells
surfactant
Airway Functions
warm air, add H2O, filter foreign
Goblet Cells
secrete mucus
Dalton’s Law
Partial Pressures Sum Total Pressure
Boyle’s Law
P1V1=P2V2
Hypocapnia
low CO2
Hypoxia
low O2 tissue
Hyperventilation
High O2
Hypoventilation
Low O2, High CO2
Emphysema
type of COPD, alveolar damage, lowers surface area
Capacity
more than one volume
Pulmonary Edema
fluid accumulation, increased diffusion distance
Pleural Fluid
lubricant
Parietal PLeura
outer
Visceral Pleura
inner
COPD
chronic obstructive pulmonary disease
RDS
Respiratory distress syndrome, surfactant deficiency
Hypoxemia
low O2 in blood, low oxygenation
Surfactant
surface tension equalizer, more in smaller alveoli
Compliance
ability to stretch (RDS/tb complications)
Elasticty
ability to return from stretch
Haldane Effect
Increased Po2 affinity lowers CO2 affinity for hemoglobin binding
Fibrosis
thickening of alveoli, diffusion barrier, lowered compliance, type of RLD
Hypoxic Hypoxia
low O2 in blood, high altitude, hypoventilation, no adequate oxygen
Anemic Hypoxia
Reduced O2 carrying, CO poisoning, anemia, problem with heme binding
Ischemic Hypoxia
stagnant, insufficient blood flow, heart failure, shock, issues with transportation
Histotoxic Hypoxia
unusable oxygen due to CN poisoning, present but not used
COPD
emphysema (alveolar damage/decrease SA), chronic bronchitis (cough/mucus), chronic, non-reversible, environmental
RDS
NRDS (lacks surfactant), ARDS (severe inflammation), acute, premature, infection
Regulated Variables
O2, CO2, pH
Arterial Po2 __ Venous Po2
>
Venous Pco2 __ Arterial Pco2
>
Venous pH __ Arterial pH
<
Alveolar Po2 __ Blood Po2
>
Blood Pco2 __ Alveolar Pco2
>
Blood Po2 __ Tissue Po2
>
Tissue Pco2 __ Blood Pco2
>
Asthma
bronchiole restriction, decreased Po2, type of constriction disease
QO2
CO x (Ao2 - Vo2)
98% O2
bound
2% O2
dissolved
7% CO2
dissolved
23% CO2
bound
70% CO2
bicarbonate
HbCO2
carbaminohemoglobin
Cl- Shift
Chloride enters RBC, HCO3- leaves
Medulla
inspiratory/expiratory muscles
Pons
ventilation
Chemoreceptors
reflexes
Phrenic Nerve
diaphram
Peripheral Chemoreceptors
carotid bodies
Protective Reflexes
bronchoconstriction, sneezing, coughing, Hering-Breuer inflation reflex
Low Po2 Innervation
Low Po2 -> K+ closed -> Depolarization -> Ca2+ open -> Vesicle Formation -> Synapse Signal -> Increased Ventilation
Pneumothorax
air flow into the cavity, collapse
Low Compliance
low stretch, RLD, fibrosis “thickening”, NRDS “surfactant”
Surfactant
disrupts the cohesive force of water, made of proteins and phospholipids
LaPlace
2(ST)/radius; smaller alveoli have more surfactant, pressure equalizes
Bronchoconstriction
increase resistance, parasympathetic
Bronchodilation
lowered resistance, sympathetic
Totalpv
ventilation rate x Tidal Volume (mL/min)
Alveolarv
ventilation rate v (Tidal Volume - Dead Volume) (mL/min)
Obstructive Lung Disease
Increased resistance, COPD, apnea, asthma (constriction)
Restrictive Lung Disease
decreased compliance, fibrosis “thickening”