Exam 3 - Lecture 22: Mycobacteriaceae

Question 1

4

Is mycobacteriacae an aerobe or anaerobe?

Question 2

4

Is mycobacteriacae motile or non-motile?

Question 3

4

Is Mycobacteriacaea sporulating?

Question 4

5

What stain do you use for Mycobacteriacaeaea?

Question 5

5

Mycobacteriacaea resists ____, _____, _____, and _____.

Question 6

5

Mycobacteriacae multiple and dividide ____.

Question 7

6

Mycobacteriacaeae pathogens = _____ colonies

Question 8

10

Mycobacteria can be stained with _____ and viewed with ______. 11

Question 9

11

Microscopically, mycobacterial infection is marked by numerous acid fast organisms growing within macrophages. Lots of _______are seen, particularly in macrophages.

Question 10

13

Mycobacteria are clumpy in _____.

Question 11

13

Cord factor is a _____ that inhibits ______ of PMNs. Small quantities of cord factor are letha in _____.

Question 12

13

Cord factor is abundant in _____ and if this is absent from Mycobacteria it means it is _____.

Question 13

15

Non-TB mycobacteria also cause problems. They are classified into _____ groups.

Question 14

19

Which group of non-TB mycobacteria is the only one of the four that does rapid instead of slow growth?

Question 15

19

Which group of non-TB mycobacteria is the only one of the four that does not produce a pigment?

Question 16

20

What do we now categorize the non-TB Mycobacteria groups as?

Question 17

22

TB is spread by ____

Question 18

22

The primary lesion of TB involves ____ and _____.

Question 19

22

_____ tuberculosis is more general.

Question 20

26

Miliary TB is also known as ______.

Question 21

27

The host response to M. tuberculosis is a ______ response or a ________.

Question 22

27

Individuals previously exposed to M. tuberculosis develop a ______ reaction upon re-exposure to the organism or its products. This reaction is the basis for the _______.

Question 23

28

What is the name for the Tuberculin skin test?

Question 24

28

The tuberculin skin test is an intradermal infection of _______.

Question 25

28

The tuberculin skin test has to incubate for ____ hours.

Question 26

28

What are the measurements for a negative, indeterminate, and positive tuberculin skin test?

Question 27

31

What is the treatment for tuberculosis?

Question 28

31

For the first 2 months of tuberculosis treatment, what 4 drugs do you take?

Question 29

31

For the 4th-6th months of tuberculosis, what two drugs do you take?

Question 30

____ is caused by a TB bacteria that is resistant to at least _____ and _____.

Question 31

______ is a rare type of MDR TB that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of the three injectable second line drugs.

Question 32

33

What test is given if it is suspected that you are allergic to the Tuberculin skin test?

Question 33

33

The Quantiferon Gold Test detects the release of _____ in whole blood when incubated with synthetic peptides representing two proteins from M. tuberculosis.

Question 34

34

What are the two keys to isolation for M. tuberculosis culture?

Question 35

38

The ____ smear is used for treatment, isolation, and public health.

Question 36

39

What is the general FDA approved M. tuberculosis molecular test?

Question 37

39

PCR also detects ____ mutation conferring rifampin resistance.

Question 38

41

Tubverculosis remains a common disease, but the majority of infections are _____ and patients recover without ever knowing they were infected.

Question 39

42

____% of individuals with HIV disease may have tuberculosis.

Question 40

44

Many mycobacteriia are ______ resistant and can be very difficult to treat.

Question 41

44

What is the most common of the Mycobacteria organisms to cause infection?

Question 42

44

M. avium intracellulare is often seen in ____.

Question 43

45

What are three things that mycobacterium avium complex is seen in? Is there any human to human transmission?

Question 44

45

Invasive cardiovascular infections of mycobacterium avium are associated with ______.

Question 45

46

Mycobacterium avium complex is resistant to ____.

Question 46

48

Is leprosy a highly contagious disease?

Question 47

48

Acquisition of M. leprae requires _____.

Question 48

51

M. leprae has to be cultured using what two things?

Question 49

52

What characterizes severe forms of leprosy (Hansen’s disease)?

Question 50

54

Early ______ are characterized by anesthetic macules with hypopigmentation. Mainly involves nerves, with anaesthesia and paraesthesia leading to loss of fingers and toes.

Question 51

56

Is leprae culturable?

Question 52

56

What is the lab diagnosis for leprae?

Question 53

57

What is treatment for Paucibacillary leprae?

Question 54

57

What is the treatment for Multibacillary leprae?

Question 55

57

With leprae, resistance to ___ and ____ has been reported.