Exam 2 Lecture 18 Flashcards

1
Q

Describe the Gram stain of Neisseria

A

Gram negative diplococci

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2
Q

True or False: Neisseria is non-motile

A

T

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3
Q

There are commensals such as N. lactamica, and this is present in the _________. It plays a large role in ______ and antibiotic _________.

A

oropharynx
immunity
resistance

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4
Q

How can Neisseria be grown in culture?

A

It needs to be enriched and contain CO2

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5
Q

What sugars do gonococcus utilize? What about meningococcus?

A

Gonococcus- Glucose
Meninges- maltose and glucose

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6
Q

True or False: Neisseria can be introduced into animals and studied for pathogenesis

A

False

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7
Q

Name the major virulence factors

A

Pili
OMPs (Opa, Por)
Lipooligosaccharide (LOS)

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8
Q

Pili attach to ____ on male urogenital epithelial cells, and on ___ on female cervical epithelium

A

CD46

CR3

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9
Q

How do pili undergo phase variation?

A

Transcriptional regulation

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10
Q

How do pili undergo antigenic variation?

A

Diff sequences

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11
Q

Genes in __ can be combined into an expressed site, known as ____

A

pilS, pilE

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12
Q

Recombination is either ________ or via _________

A

intrachromosomal

transformation

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13
Q

How many silent gene copies does the pilus have?

A

17

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14
Q

How many variable regions does the pilus have?

A

6

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15
Q

____ is the most abundant structural surface protein in Neisseria

A

Por

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16
Q

___ is involved in attachment and invasion of host cells by binding to CR3 receptors in women

A

Por

17
Q

While there are 12 genes for Opa in _ ______, there are about 3-4 in __ __________

A

N. gonorrhoeae

N. meningitidis

18
Q

A single strain may express ___ Opa proteins

A

0-3

19
Q

When Opa is expressed, colonies are ______. When Opa is not expressed, colonies are _______.

A

opaque

transparent