Exam 1: Tissue Mechanics Flashcards
Primary tissue components
Collagen
Elastin
Ground substance
Water
Collagen has continuous _____ through growth to maturity
Metabolic turnover
At maturity the collagen fibers become more
Stable
Collagen chains are synthesized ans secreted by
Fibroblasts
Collagen molecules align in the ____ in a ____ arrangement
Extracellular matrix; parallel
Collagen can stretch to ____ its original length
110%
Ligaments change under tension
Inc ligament strength
Inc ligament size
Increased lig size is accomplished by
Inc # of collagen fibrils
Inc collagen fibril diameter
Inc cross-linking
Inc collagen fibril packing density
Immobilization causes these degenerative ligament (collagen) changes
Dec diameter Dec density Dec fibril # Dec overall mass Dec metabolism
Immobilization at ligament-bone junction changes
Inc osteoclast activity
Bone resorption
Disruption of diffusion
Immobilization increases the risk of ____ at the ligament-bone junction
Avulsion injuries
Elastin can stretch to ____ its original length
150%
Age-related changes to elastin
Lose resiliency
Fragmentation/fraying
Calcification
Inc cross-links
Contents of Ground Substance
GAGs
Plasma proteins
Small proteins
Water
GAGs, plasma proteins and small proteins all attract
Water
Water = _____% of total CT content
60-70%
4 major GAGs
Hyaluronic acid
Chondroitin-4-sulfate
Chondroitin-6-sulfate
Dermatan sulfate
_____ is found in high concentration within GAGs
Glucosamine
Hyaluronic acid + water is a powerful _____
Lubricant
Water maintains _____ between collagen fibers which allows ____ and prevents _____
Critical distance
Allows free gliding; prevents excessive cross-linking
Mechanical forces play an important role in ______ of tissue as well as ______
Development, maintenance, remodeling
Damage and disease
Tissue biomechanics is study of how different parts of human body _____
React to external forces
When a load produces forces that push material together
Compression
When a structure is stretched longitudinally
Tension
Forces acting parallel to each other in opposite directions
Shear
Forces twisting/rotating in opposite directions about long axis
Torsion
Combination of tensile and compressive loads
Bending
Behavior of compressed structures depends on
Its length; how far or long load is applied
Nearly constant compressive forces are transmitted to
Vertebral body and IVD
Examples of compression injuries
Bruises
Crushing
Compression fractures
Pinching
Compression fractures happen a lot in _____ because there is _____
Older female patients
Too much force/too little bone density
Tension is a _____ force
Stretching or pulling
Tension elements of the body are ___
Soft tissues
Tensile forces occur in the IVD during ____ movements
Rotational
Examples of tension injuries
Sprain/strain
Avulsion fractures
Nerve traction injuries
_____ bones are most at risk for fracture due to shear forces
Cancellous
In the spine ____ resist shear forces
Facet joints and annulus fibrosus fibers
Examples of shear injuries
Brain injuries
ACL/PCL injuries
Blisters
Spine injuries
Excessive torsion can result in failure of:
Facet joint
Part interarticularis
Capsular tears
Circumferential tear of annulus
____ fractures of long bones are another example of torsional load failure
Spiral
_____ is a combination of compression and tension
Bending
Tissue responses in response to force
- Deformation
- Growth/remodeling
- Failure
Local shape change due to applied forces
Deformation
Extent of deformation depends on
- Material properties
- Size/shape
- Environmental
- Force (magnitude, direction, duration)
External force acting to deform a material
Stress
Stress measures the ___ of the force
Intensity
Magnitude of deformation as result of applied stress/loading
Strain
Strain is a measure of _____
Degree of deformation
Stress is _____, strain is _____
What is done to object; how object responds
Strain is ____ to stress
Proportional
In addition to strain in direction of applied stress, there is also strain ____ to direction of loading
Perpendicular (orthogonal)
Maximum stress a tissue can withstand without permanent deformation
Strength
Yield strength
Stress at yield point of a material beyond which permanent deformation will occur
Ultimate strength
Maximal stress a material can withstand prior to initiation of failure
Failure strength
Stress where material actually breaks/ruptures
Ductility represents how much ____ the structure can sustain _____
Force and deformation; before it fails
Ductile tissues fail at ____ but can withstand ____
Low stress; large strain
Brittle tissues can withstand ___ but fail with ___
High stress; low strain
Total energy required to cause material failure
Toughness
Toughness is estimated by observing
Total area under stress/strain curve
Bone = more ___, very ____
Brittle; strong
Overall toughness of bone =
Low
Tendon = moderate for both
Strength and ductility
Overall toughness of tendon =
High
Ligament = more ___ and lower ____
Pliant; strength
Overall toughness of a ligament =
Moderate
Ability to return to original shape when load is removed
Elasticity
Plastic region
Response of material after yield point
Deformation persists after stress removal
Elastic stretch represents _____ behavior
Spring-like
Property of materials to resist loads that produce shear/tensile forces
Viscosity
Viscous stretch refers to
Putty-like behavior
Deformation by tensile stress remains after stress is removed
When material shows both properties of viscosity and elasticity
Viscoelasticity
Viscoelasticity is affected by both ____ and ____ it is subjected to constant load
Rate of loading; length of time
Viscoelastic structures show time dependent loading characteristics:
Creep
Relaxation
Hysteresis
Continued deformation over time when constantly loaded
Creep
Creep in tissue occurs due to
Expulsion of water
Eventual decrease in stress that occurs as fluid is no longer exuded
Relaxation
Energy loss by viscoelastic materials when subjected to loading/unloading
Hysteresis
The larger the load the ___ the hysteresis
Greater
What does it mean when hysteresis decreases
Less capacity to absorb the shock energy
What can happen as a result of decreased hysteresis
Inc deformation
Molecular disruption
Compliant tendons can absorb elastic energy more easily they have ___ hysteresis which could be related to ___ injury risk
Dec; dec
In general, weight training will ____ stiffness, while flexibility exercises will ___ compliance
Increase; increase
_____ hysteresis is advantageous
Low
Hysteresis is dependent on
Rate of loading/unloading
Dynamic activities (plyo/ballistics) can increase pliability of MTC and thereby
Dec hysteresis (dec injury risk)
Toe region
Normal range of motion
Toe region is the little force required to remove the
Crimping/slack in the tissue
After toe region, tissue
Resists elongation much more strongly
Micro-failure occurs after
Taking out slack in soft tissue
During micro-failure the tissue is still _____
Elastic
Example of micro-failure
Grade 1 sprain (small amount of damage)
Yield stress is the stress when
Plastic deformation starts
In yield stress, when the force is taken off
It will stay deformed
Plastic deformation example
Grade 2 sprain
Example of tissue rupture
Grade 3 sprain