Exam 1 Quiz 1 Flashcards
microbiology
area of biology that deals with living things ordinarily too small to be seen without magnification
microbes or microorganisms
bacteria, viruses, protozoa, algae, and fungi
microbes are
tiny living systems (except viruses)
what can microbes do
-metabolize
-reproduce
-differentiate
-communicate
-move
-evolve
microbes metabolism
uptake chemicals from environment and transform within the cell and eliminate wastes
microbes reproduction
chemicals from environment are turned to new cells under the direction of new cells
microbes differentiation
form a new structure as part of a cellular life cycle
microbes communication
interact by chemicals that are released and taken up
microbes movement
self-propulsion
microbes evolution
evolve to display new biological properties and resistant
when did procaryotes appear
3.6 billion years ago
when did eukaryotes appear
1.8 billion years ago
How many microbes cause disease?
2,000 however there are billions of various microbes
ratio of normal cells to bacteria cells in humans
1:10
what percent of bacteria utilize photosynthesis
52%
normal microflora
-not attacked by our immune system
-inhibit pathogenic bacteria from gaining access to our bodies
-digestion
-provide nutrients we cannot make
how can microbes influence human society?
-photosynthesis
-decomposition
-nitrogen cycle
-Regulation of temperature
robert hooke
-wrote micrographia published in 1665
-oxford grad
-fought w/ Newton
-curator of experiments for London
Leeuwenhoek
-daddy of microbio
-homebody fabric merchant
-built single lens microscopes by hand to look at thread counts
-discover first ‘animalcules’
animalcules
little things that moved
leeuwenhoek’s microscope
-built by hand
-single lens
-up to 300x
hooke’s microscope
-up to 30x
-compound microscope
Spontaneous generation theory
-brought up by Aristotle but proven to be incorrect by Francesco Redi in 1668 with his fly experiment
-Idea came back up after Leeuwenhoek found ‘animalcules’
Louie Pasteur
killed spontaneous generation theory once and for all by using a swan neck flask
All contributions from Louie Pasteur
-disproved spontaneous generation
-determined that bacteria were capable of chemical processes
-using heat to sterilize liquids
-discovered attenuation
-created vaccines for cholera, anthrax, and rabies
attenuation
weakened form of a bacteria or virus
Robert Koch
-1800
-proved the germ theory of disease
-german physician
-presented steps ‘postulates’
Koch’s postulates
- same bacteria is present in all cases of disease and not found in healthy people
- suspected pathogen must be grown in pure culture
- pathogen must be introduced to host and cause the same disease
- pathogen must be reisolated in pure culture
what inspired Koch’s postulates?
Bacillus anthracis and Mycobacterium tuberculosis
problems with first postulate
-carrier/ asymptomatic state
-symptoms w/o pathogen
-bacteria not causing symptoms
-slow growth rate
problems with second postulate
-not all can be grown in pure culture
-hard to replicate specific conditions
-slow growth
problem with third postulate
-not ethical on human
-bacteria require cofactors
-not everything will be infected by same bacteria
Stanley Falcow
extended molecular and genetics into the postulates
potential fifth postulate
show that an antibiotic can inhibit/kill the microorganism
Ignaz Semmelweis
worked with midwives and hospital deliveries and proposed that handwashing prevented the spread on bacteria