Exam 1: Intro to Cytokines Flashcards
1
Q
Cytokines
Overview
A
- Low MW glycoprotein mediators
- Released by lymphocytes, leukocytes, and non-leukocytic cells
- Influences growth, differentiation or function of many cell types
2
Q
Communication pathways created by cytokines are called…
A
cytokine networks
3
Q
Cytokines secreted by lymphocytes called…
A
lymphokines
4
Q
Cytokines secreted by monocytes and macrophages called…
A
monokines
5
Q
Chemokines
A
“Chemoattractant cytokines”
- Cause chemotactic migration of leukocytes
- Promotes recruitment & activation of cells
- Increases effector functions
- ~ 50 chemokines bind ~ 20 receptors
6
Q
Pleiotropy
A
One cytokine has multiple different effects
7
Q
Redundancy
A
Multiple cytokines appear to induce the same functions.
8
Q
Cytokine Regulation
A
- Transient production
- Low concentrations made
- Levels elevated in local environment
- Short half-life
- Control expression of its receptor
