EX1 Antigen Processing/Presentation - Stiner Flashcards
CD8 cells recognize MHC class (I or II)
MHC class I
CD4 cells recognize MHC class (I or II)
MHC class II
______ _____ is the bridge between antigen recognition and the ignition of a full-blown immune response
antigen presentation
Antigen presentation enables T cell-mediated _______ or augments antibody production by ______
killing
B cells
Antigen presentation is ______ ______, allowing the deployments of appropriate immune responses under different conditions
context dependent
Antigen recognition without antigen presentation can result in ________, this minimize the chances of _________ activity
tolerance
autoimmune
Antigen presentation is modulated by _______ _______
co-stimulatory molecules
Successful antigen presentation results in activation of _______
T cells
What are the three main antigen presenting cells (APCs)
dendritic cels
macrophages
B cells
All nucleated cells can present endogenous antigens in association with MHC class (I or II) molecules
MHC class I
Pathway 1 of antigen processing involves (endogenous/exogenous) antigens
exogenous
Pathway 2 of antigen processing involves (endogenous/exogenous) antigens
endogenous
In this pathway of antigen processing the antigens are digested to small peptides and presented to CD8 cells via MHC class I; uses ubiquitin
Pathway 2 (cytosolic pathway)
In this pathway of antigen processing the antigens are taken into the cell, small peptides are generated and presented to CD4 cells via MHC class II
Pathway 1 (endocytic pathway)
The processes by which antigens are digested and placed on the cell surface with correct MHC molecules
antigen processing
The invariant chain/CLIP of MHC class II processing does what?
keeps the MHC from binding with anything while it is forming/traveling
Both class I and class II MHCs are formed in the ______
rough endoplasmic reticulum (RER)
MHC class (I or II) makes use of an endocytic compartment containing the antigen to be presented
MHC class II
MHC class (I or II) contains α1, α2, α3, and a β2 component
MHC class I
MHC class (I or II) contains an α1, α2, β1, and a β2 component
MHC class II
MHC haplotypes can influence three things like…
how an individual responds to certain pathogens
susceptibility to certain diseases
transplant success
True or False
MHC genes are highly polymorphic
True; roughly 10^13 different combinations; the alleles are co-dominantly expressed
True or False
MHC molecules have a broad specificity for peptides
True; many different peptides can bind within MHC binding clefts
True or False
Peptides associated with MHC have a rapid on and rapid off rate
False; they have a slow on and off rate
True or False
MHC molecules do discriminate from self and foreign peptides
False; they do not discriminate
MHC ________ allows individual T cells to recognize foreign antigens displayed on the surface on an individual APC; allowing recognition of self or non-slef
MHC restriction
True or False
In order for the antigen to be properly presented the T-cell receptor (TCR) must engage the MHC molecule and other co-stimulatory molecules
True
The main secondary signals of MHC/TCR recognition are ______ and _____
CD28 (on T cell)
B7 (on APC)
Which T cell recognizes cytosolic proteins
CD8
Which T cell recognizes extracellular/intravascular pathogens
CD4
____ and ____ are non-covalently associated to the TCR and they are required for antigen recognition and signaling
CD3 and ζ (zeta)
_______ competitively binds to B7; blocking signals from the TCR
CTLA-4
True or False
You must have both the MHC and co-stimuntory molecule in orderer for the T cell to be activated
True
What interleukin drives the development of Th1 cells
IL-12
What interleukin drives the development of Th2 cells
IL-4
Th (1 or 2) cells provide help for cell mediated immune responses
Th1
This is an important Th1 cytokine
IFN-γ
Th (1 or 2) cells provide help for humoral immune responses
Th2
This is an important Th2 cytokine
IL-4
