Epithelium Flashcards

1
Q

where are microvilli located

A
  • GI tract

- kidney

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2
Q

where are stereocilia located

A
  • epididymis

- ear cochlea

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3
Q

which apical modifications increase surface area

A
  • microvilli

- stereocilia

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4
Q

which apical modifications move substances

A

cilia

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5
Q

where are cilia located

A
  • respiratory system

- oviduct

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6
Q

what are microvilli made of

A

actin filaments

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7
Q

actin-binding proteins of microvilli

A
  • fimbrin

- fascin

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8
Q

lateral anchoring proteins of microvilli

A

myosin I

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9
Q

amorphous apex of microvilli

A

villin

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10
Q

cilia core made of

A

axoneme (9 doublets + 1 doublet microtubules)

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11
Q

what kind of arms for cilia

A

dynein arms

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12
Q

cilia function

A

transport materials along surface - beating

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13
Q

consequence of primary ciliary dyskinesia (immotile cilia)

A
  • dextrocardia
  • no mucus removal from lungs
  • infertility
  • impaired skull sinuses
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14
Q

3 cell junctions

A
  • tight (occluding) junctions
  • anchoring junctions
  • communicating (gap) junctions
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15
Q

zonula occludens type

A
  • cell to cell
  • tight junction
  • belt
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16
Q

zonula adherens

A
  • actin filaments<>actin filaments

- anchoring junction

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17
Q

macula adherens (desmosome)

A
  • intermediate filament<>intermediate filament

- anchoring junction

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18
Q

zonula occludens function

A

prevent diffusion (block paracellular pathways)

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19
Q

zolnula occuldens location

A
  • stomach (secretory)

- kidney (absorptive)

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20
Q

anchoring junctions function

A
  • stability
  • mechanical strength
  • connect cell filaments
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21
Q

zonula adherens filaments

A

actin filaments

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22
Q

zolnula adherens transmembrane link protein

A

cadherin

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23
Q

macula adherens filaments

A

intermediate filaments

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24
Q

what do intermediate filaments of macula adherens bind to?

A

intracellular plaque

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25
Q

macula adherens transmembrane link protein

A

cadherin

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26
Q

pemphigus

A

autoimmune disease of cell junctions for middle aged patients

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27
Q

pemphigus presentation

A

mucous membrane blistering, widespread skin

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28
Q

pemphigus cause

A

desmoglein (cadherin) can’t anchor the cells because antibodies for desmosomal proteins

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29
Q

2 connexons with 6 protein subunits each (connexions)

A

gap junctions

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30
Q

most common gap junction locations

A
  • epithelia
  • cardiac and smooth muscle
  • embryonic tissues
31
Q

gap junction function

A

transport small molecules and ions

32
Q

basal lamina make up

A
  • from epithelium
  • laminin
  • collagen type 4
33
Q

reticular lamina make up

A
  • from connective tissue

- collagen type 3

34
Q

cell attachment connects actin filaments to basement membrane

A

focal adhesion

35
Q

cell attachment connects intermediate filaments to basement membrane

A

hemidesmosome

36
Q

focal adhesion peripheral protein

A

talin

37
Q

focal adhesion transmembrane protein

A

integrin

38
Q

hemidesmosome attachment before basement membrane

A

intracellular plaque

39
Q

hemidesmosome transmembrane protein

A

integrin

40
Q

which epithelium has dome cells

A

transitional epithelium

41
Q

endocrine gland features

A
  • secretion into blood/lumph (internal)
  • NO ducts
  • hormone production
42
Q

exocrine gland features

A
  • secretion to surface

- ducts

43
Q

exocrine gland types

A
  • holocrine
  • apocrine
  • merocrine
44
Q

holocrine function

A

cell destruction (release whole cell)

ex: Sebaceous gland

45
Q

apocrine function

A

apical cytoplasm pinching (release vesicle)

ex: Mammary gland

46
Q

merocrine function

A

exocytosis (no cell part lost)

ex: goblet cells, pancreas

47
Q

3 types of merocrine glands

A
  • serous
  • mucous
  • mixed
48
Q

serous merocrine secretions

A

protein

49
Q

mucous merocrine secretions

A

water (mucins)

50
Q

serous gland cell structure

A
  • active (euchromatic) nucleus
  • dark secretory granules
  • lots of ER
51
Q

what color do serous glands stain?

A

dark

52
Q

serous gland location

A
  • pancreas

- parotid salivary gland

53
Q

mucous glands cell structure

A
  • inactive (heterochromatic) nucleus
  • pale secretory glandules
  • little RER
54
Q

what color do mucous glands stain

A

pale

55
Q

mucous gland function

A

protection and lubriction

56
Q

mucous gland location

A
  • Brunner’s glands (stomach)

- Goblet cells (respiratory & intestine)

57
Q

unicellular exocrine glands function

A

-secrete mucous

58
Q

unicellular exocrine glands location

A
  • goblet cells
  • intestine
  • respiratory tract
59
Q

which type of exocrine gland is along columnar epithelial cells?

A

unicellular exocrine glands

60
Q

which gland has an alveolar secretory part?

A

serous

61
Q

which gland has tubular secretory part?

A

mucous

62
Q

which gland has tubuloalveolar secretory part?

A

mixed

63
Q

what kind of tissue for carcinoma?

A

barrier epithelial tissue

64
Q

what kind of tissue for adenocarcinoma?

A

glandular tissue

65
Q

what are the arms attached to doublets composed of?

A

dynein

66
Q

what does a mutation in a gene encoding keratin affect?

A

macula adherens (desomosme)

67
Q

what has intermediate filaments connected to basal lamina?

A

hemidesmosome

68
Q

what causes a reduction in bronchial epithelium?

A

cilia

69
Q

Zonula adherens actin-binding protein?

A

Vinculin (a-protein)

70
Q

Zonula adherens peripheral protein?

A

Catenin

71
Q

Which is a tighter link, zonula adherens or macula adherens?

A

Macula Adherens (desmosomes)

72
Q

Mixed seromucous glands consist of which types of cells?

A
  • mucous cells (tubules)

- serous cells (serous demilunes)

73
Q

What kind of gland is the submandibular salivary gland?

A

mixed (seromucous) gland

74
Q

2 types of exocrine glands

A
  • unicellular (goblet cells)

- multicellular (mucous, serous glands)