Epithelium Flashcards
where are microvilli located
- GI tract
- kidney
where are stereocilia located
- epididymis
- ear cochlea
which apical modifications increase surface area
- microvilli
- stereocilia
which apical modifications move substances
cilia
where are cilia located
- respiratory system
- oviduct
what are microvilli made of
actin filaments
actin-binding proteins of microvilli
- fimbrin
- fascin
lateral anchoring proteins of microvilli
myosin I
amorphous apex of microvilli
villin
cilia core made of
axoneme (9 doublets + 1 doublet microtubules)
what kind of arms for cilia
dynein arms
cilia function
transport materials along surface - beating
consequence of primary ciliary dyskinesia (immotile cilia)
- dextrocardia
- no mucus removal from lungs
- infertility
- impaired skull sinuses
3 cell junctions
- tight (occluding) junctions
- anchoring junctions
- communicating (gap) junctions
zonula occludens type
- cell to cell
- tight junction
- belt
zonula adherens
- actin filaments<>actin filaments
- anchoring junction
macula adherens (desmosome)
- intermediate filament<>intermediate filament
- anchoring junction
zonula occludens function
prevent diffusion (block paracellular pathways)
zolnula occuldens location
- stomach (secretory)
- kidney (absorptive)
anchoring junctions function
- stability
- mechanical strength
- connect cell filaments
zonula adherens filaments
actin filaments
zolnula adherens transmembrane link protein
cadherin
macula adherens filaments
intermediate filaments
what do intermediate filaments of macula adherens bind to?
intracellular plaque
macula adherens transmembrane link protein
cadherin
pemphigus
autoimmune disease of cell junctions for middle aged patients
pemphigus presentation
mucous membrane blistering, widespread skin
pemphigus cause
desmoglein (cadherin) can’t anchor the cells because antibodies for desmosomal proteins
2 connexons with 6 protein subunits each (connexions)
gap junctions