epigenetics 2 Flashcards
1
Q
what turns genes on?
A
HATs
2
Q
what turns genes off?
A
HDACs
3
Q
epigenetic regulation of gene expression is done by?
A
HATs and HDACs
4
Q
HDAC9 overexpression results in
A
blocks cardiomyocyte hypertrophy
Adenovirus (overexpresses HDAC9) this infects cardiac myocytes and blocks hypertrophy
5
Q
overexpression of HDAC 9 results in
A
myocytes were smaller with no sacromeres.
It blocks cardiac hypertrophy
6
Q
HDAC9 knockout stimulates ____
A
cardiac hypertrophy in mice
7
Q
epigenetic regulation of hypertrophy by HDAC9
A
pro-hypertrophic gene expression, plus HDAC9, leads to pro-hypertrophic gene expression
