Enzyme Regulation Flashcards
Inhibitor
a molecule that binds to an enzyme preventing it from catalyzing reactions
if binding involves covalent bonds then inhibition is often _______
irreversible
if binding is weak, inhibition may be _____
reversible
comptetitve inhibition
inhibitor binds to the same site as the substrate
noncompetitive inhibition
inhibitor binds somewhere other than the avtive site
what does a noncompetitive inhibitor cause
the enzyme to become insensitive to substrate concentrations
how does noncompetitive inhibition work?
alters enzyme conformation rendering the active site unreceptive or less effective
why do inhibitors exist?
to maintain homeostasis
allosteric enzyme
has a seonc binding site that is not the active site, called the allosteric site
what are the two conformations of an allosteric enzyme?
active and inactive, naturally
allosteric site
a specific binding site ont he enzyme that is not the active site - can be located between subunits (where subunits join)
effectors - allosteric regulators
a regulator that can activate or inhibit by the enzyme by binding to an allosteric site
classifications of effectors
allosteric inhibitor
allosteric activator
allosteric inhibitor
statbilizes the conformation that lacks an active site (inactive form)
allosteric activator
stabilizes the conformation that has a functional active site
