Endocrine Pancreas Flashcards
What are the hormones secreted by the endocrine portion of the pancreas?
- Insulin
- Glucagon
- Somatostatin
Where is the endocrine pancreas located? what are the cell types?
Tail of the pancreas; islets of langerhans
Insulin is related by _____ cells results in:
[increase/decrease] in blood glucose
[increase/decrease] in glycogen synthesis
[increase/decrease] in gluconeogenesis
[increase/decrease] in trygliceride and protein synthesis
Beta; decrease; increase; decrease; increase
Glucagon is related by _____ cells. Its release is inhibited by ______.
alpha; serum glucose/insulin
What does glucagon increase?
- serum glucose levels
- Glycogenolysis
- Gluconeogenesis
- Lipolysis
- Output of ketones by liver
What are factors (hormones) that influence diabetes?
- Insulin
- Glucagon
- Catecholamines (epi and NE)
- Growth hormone
- Glucocorticoids
Disorder of carbohydrate, fat, and protein metabolism
Diabetes mellitus
Absolute insulin deficiency
Type I diabetes
Inadequate or defective insulin receptor or response to insulin
Type II diabetes
What happens with uncontrolled diabetes?
A person is unable to transport glucose into fat and muscle cells (body is start and begins to metabolize fats and proteins for energy)
Autoimmune destruction of beta cells; can be the result of a genetic disposition or due to viral infection of coxsackie B or measles; prone to ketoacidosis
Type I diabetes
About __% of diabetes cases are type I while __% are type II
10; 90
Body cells are resistant to insulin; pts are hyperglycemic and most are obese (80%); condition may improve with weight loss and exercise
Type II diabetes
Gestational diabetes occurs in ___% of pregnancies.
2-5
What are the risk factors for gestational diabetes?
- Family history
- Glycosuria
- Hx of stillborn or spontaneous abortion
- Obesity
- 5 or more pregnancies
What are women at a higher risk for if they develop gestational diabetes?
- Complications during pregnancy
- Mortality
- Fetal Abnormalities
What are the normal resting glucose levels? Glucose intolerance? diabetes? gestational diabetes?
<100
100-125
>125
=>105
What are the signs and symptoms of diabetes?
- Poly uria
- Polydipsia
- Polyphagia (usually not in type II)
Why does polyuria occur?
High glucose levels = high glucose in urine; osmotic pressure moves water into urine
What are other signs and symptoms of hyperglycemia?
- Recurrent blurred vision
- fatigue
- Paresthesias (tingling in skin)
- Skin infections
What are the acute complications of diabetes when glucose levels are too hight?
- Diabetic ketoacidosis
2. Hyperglycemia, hyperosmolar syndrome
What occurs due to metabolism of fats and is often preceded by emotional or physical distress?
diabetic ketoacidosis (distress causes person to inadequately use insulin)
What are signs and symptoms of diabetic ketoacidosis?
- 1-2 days polyuria, polydipsia, nausea and vomiting, marked fatigue
- Eventual stupor, may lead to coma
- May have abdominal pain and tenderness
- Fruity smell to breath (ketones)
- Hypotension and tachycardia, secondary to decrease in blood volume
Diabetic is more common in type [I/ II] while hyperosmolar syndrome is more common in type [I/ II]
I; II
Result of increase in serum osmolarity, but no increase in ketones
Hyperosmolar syndrome (hyperglycemia)
What are the S and S of hyperglycemia?
- Dehydration
- Polyuria and thirst, leading to decreased urine output
- Neurological signs