Endocrine 2 Flashcards
Overall functions of the endocrine system
- regulates organic metabolism and H2O and electrolyte balance
• 2. Induces adaptive changes to help cope with stressful situations
• 3. Promotes smooth, sequential growth and development
• 4. Controlling reproduction - Regulating red blood cell production
- Along with the autonomic nervous system, controlling and integrating activities of both the circulatory and digestive systems.
How many hormones does the anterior pituitary gland secrete?
6
What do both the pancreas and hypothalamus secrete?
Somatostatin
Function of vasopressin
Promotes H2O reabsorption by binding V2 receptors and cause vasoconstriction of arterioles throughout the body by binding with V1 receptors on arteriolar smooth muscle.
Function of insulin
Promotes conversion of glucose into glycogen by stimulating one particular hepatic enzyme, while glucagon, stimulates another hepatic enzyme to enhance the degradation of glycogen to glucose.
Name a chemical messenger that may be a hormone or a neurotransmitter
Norepinephrine
Where is norepinephrine secreted from? x 2
- As a hormone by the adrenal medulla
- As a neurotransmitter from sympathetic postganglionic nerve fibers.
Name an organ that perform nonendocrine functions as well as hormone secretions
Testes
Dual funciton of testes
Produce sperm and also secrete the male hormone testosterone.
What does the hypothalamus-pituitary integrate?
Nervous and endocrine systems
What does pituitary function depend on
Hypothalamus
Where does the pituitary lie?
At base of brain below hypothalamus
What is the pituitary-hypothalamus connected by?
By nerve fibers and blood vessels
What does the hypothalamus-pituitary regulate?
Function of – thyroid – adrenal – reproductive glands – somatic growth – lactation – water metabolism
Where does the hypothalamus lie?
At base of brain
How does pituitary connect to base of brain?
By infundibular stalk
Anterior pituitary (developed from)
Epithelial structure develops from Rathke’s pouch
Posterior pituitary (structure)
Neural structure develops from floor of midbrain, consists of nerve fibers that run from hypothalamus to
anterior pituitary
What does the posterior pituitary and hypothalamus form?
Neuroendocrine system
What is the posterior pituitary composed of?
Neural tissue
What does the posterior pituitary gland store?
Two peptide hormones in axonal ends
What does the posterior pituitary release?
Oxytocin and Vasopressin (Antidiuretic hormone, ADH)
What are peptides packaged into?
Vesicular granules
Vesicular peptides transport
Transported down axons into posterior lobe
Where is peptide release from
Terminal (similar to neurotransmitter release)
Other name for antidiuretic hormone (ADH)
Vasopressin
Vasopressin during a water deficit
Secretion of vasopressin increases. This increases water reabsorption.
Vasopressin during an excess of water
Secretion of vasopressin decreases. Less water is reabsorbed. More is eliminated
What does the secretion of vasopressin cause?
Increases the permeability of the tubule cells to water.
What exists outside tubules for the transport of water by osmosis?
An osmotic gradient
What percent of water reabsorption is obligatory in the proximal tubule?
65%
Mechanism of action of vasopressin
- Blood-borne vasopressin binds with its receptor sites on the basolateral membrane of a principal cell in the distal or collecting tubule.
- This binding activates the cyclic AMP (cAMP) second-messenger system within the cell.
- Cyclic AMP increases the opposite luminal membrane’s permeability to H2O by promoting the insertion of AQP-2 water channels into the membrane. This membrane is impermeable to water in the absence of vasopressin.
- Water enteres the tubular cell from the tubular lumen through the inserted water channels.
- Water exits the cell through a different water channel (either AQP-3 or AQP-4) permanently positioned at the basolateral border, and then enters the blood, in this way being reabsorbed.
What does vasopressin control?
Blood volume
What does vasopressin act on? and why
On kidney to increase water reabsorption in distal tubule