E4: pit Flashcards
syndrome of inappropriate ADH (SIADH)
excessive amounts of ADH resulting in H2O imbalance
(excess ADH=too much ANTI=retention of tooo much H2O
cause of SIADH
- trauma
- medications
- tumors producing ADH
- infected lung tissue producing ADH
- post-pituitary surgery
- feedback inhibition
pathway of SAIDH
hypothal–> post. pit–> increased ADH secretion–> increased H20 reabsorption–> fluid retention
clinical mani of SAIDH RT retention
- hyponatremia (dilutional)
- HTN
- edema
- urine is low concentrated output
- increased urine sodium
main loop with SAIDH
increased H20 reabsorption inhibits post pit
what if the entire pituitary gland has problems
if the mother gland aint happy– no one happy
panhypopituitarism
deficiency of one or more hormones of the pituitary (usually the ant. pit)
decreased Gh
dwarfism
decreased ACTH
addisons
decreased TSH
hypothyrodidm
decreased LH and FSH
sexual and reproductive disorders
decreased ADH
diabetes insipidus
panhyperpituitarism
oversecretion of one or more of the hormones of the pituitary (usually the ant pit)
increased GH
giantism/acromegaly
increased ACTH
cushings disease
increased TSH
hyperthyroidism
increased FSH and LH
sexual/repro problems
increased ADH
SIADH
increased prolactin
Galactorrhea (excessive breast milk)
metabolic syndrome
a combination of medical conditions:
- insulin resistance (T2 DM)
- HTN
- central obesity
- high lipid/cholesterol
patho of metabolic syndrome
- Not known
- genetic role (obesity, lack of exercise)
- systemic inflammation
- -increased CRP
- -increased fibrinogen
