Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

561 Pharm > Drugs for Osteoporosis > Flashcards

Drugs for Osteoporosis Flashcards

1
Q

osteoporosis

A

decreased bone density
increased Fx risk
bone more porous and less dense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

risk factors for osteoporosis

A

postmenopause
old age
medications
endocrine disorders
inflammatory arthopathy
hematopoietic disorders
nutrition disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

DEXA scan

A

measure bone density with x ray beam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

agents affected bone mineralization

A

para thyroid hormone
Ca
vitamin D
calcitonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How does parathyroid hormone affect bone mineralization?

A

promotes bone resorption by stimulating osteoclasts
enhance renal production of vitamin D and retentino of Ca

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does Ca affect bone mineralization?

A

regulator of PTH secretion
binds ca sensor on PT gland regulating PTH secretion
excess PTH increases bone
resorption
direct role in bone structure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does vitamin D affect bone mineralization?

A

stimulate intestinal absorption of Ca
regulate PTH: low vit D stimulates PTH causing bone resorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does Calcitonin affect bone mineralization?

A

lowers blood levels of Ca, opposing PTH activity
inhibit osteoclast activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

osteoanabolic agents MOA

A

increase osteoblasts
PTH analog allowing intermittent exposure increasing bone formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

romosozumab MOA

A

monoclonal antibody
activate osteoblasts and inhibit osteoclasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

biphosphonates MOA

A

kill osteoclasts, reduce bone resorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

denosumab MOA

A

inhibit osteoclasts
monoclonal antibody vs RANKL NZ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

biphosphonates side effects

A

GI disturbances - take w water and sit up
osteonecrosis of jaw
femur Fxs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

biphosphonates clinical use

A

first line treatment for post menopausal osteoporosis/glucocorticoid induced osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

biphosphonate names

A

alendronate/fosamax

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

SERMs MOA

A

mimic estrogen, reduce bone resorption without stimulating breat/uterine tissue

17
Q

SERMS common names

A

raloxifene/evista

18
Q

SERMs side effects

A

hot flashes
leg cramps
increased risk of venous thromboembolism

19
Q

SERMs clinical utility

A

prevent/treat post menopausal osteoporosis
safe for ppl with breast cancer risk

20
Q

Calcitonin common medications

A

Miacalcin/Salmon

21
Q

Calcitonin MOA

A

decrease blood Ca level
inhibit osteoclast activity
to reduce bone resorption

22
Q

Calcitonin side effects

A

nasal irritation
hot flashes

23
Q

Calcitonin clinical use

A

less commonly used bc less effective than others
analgesic effect in acute vertebral fractures

24
Q

PTH analogs common medications

A

teriparatide/Forteo
abaloparatide

25
Q

PTH analog MOA

A

stimulate osteoblast
promote bone formation

26
Q

PTH analog side effects

A

leg cramps
dizzy
nausea

27
Q

PTH analog clinical use

A

for high risk pts like prev Fxs, subcutaneous daily injections

28
Q

monoclonal antibodies common medications

A

denosumab/Prolia, Xgeva

29
Q

Monoclonal antibodies MOA

A

bind/inhibit RANKL to reduce osteoclast formation/survival

30
Q

monoclonal antibodies side effects

A

skin reaction at injection site
osteonecrosis of jaw
hypocalcemia

31
Q

monoclonal antibodies clinical use

A

used in postmenopausal women at high risk of Fx and intolerant of other osteoporosis treatments

32
Q

vitamin D supplementation

A

ensure adequate absorption from gut
cholecaciferol D3 and ergocalciferol D2

33
Q

vitamin C supplementation

A

dairy, leafy grees, fortified

34
Q

PT considerations for bisphosphonates

A

Gi side effects
take at least 1 hr before session
monitor for atypical femur fracture or jaw osteonecrosis

35
Q

PT considerations for SERMs

A

hot flashes, cramps
monitor for clots

36
Q

PT considerations for PTH analogs

A

leg cramps
dizziness

37
Q

PT considerations for monoclonal antibodies

A

joint/back/arm/leg pain
low calcium

561 Pharm (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions