Drugs

Question 1

Amphetamine

Answer 1

Stimulant
Leaks from presynaptic cell terminal (DA, NE)
Peptide

Question 2

Cocaine

Answer 2

Stimulant.
Blocks reuptake from synapse
Peptide

Question 3

NMDA (ecstasy)

Answer 3

Stimulant. Hallucinogen.
Works on DA and 5HT
Low doses increase DA
Higher doses increase 5HT- euphoric, like LSD

Question 4

Nicotine

Answer 4

Stimulant, mostly.

Bonds to acetylcholine receptors, makes us have more. Agonist at first, then acts as antagonist

Question 5

Opiates

Answer 5

Ex. Morphine, heroin.

Have 3 types of opiate receptors. Regulate pain response.
Reinforce themselves. Indirectly activate DA.

Question 6

PCP

Answer 6

Dissociative. Combative behavior. Gets into Glu receptor (schizophrenia pathway).

Question 7

Marijuana

Answer 7

THC is acting ingredient. Have endogenous cannibinoids. Inhibit activity.
Receptors in substantia nigra, hipp, and cortex

Question 8

Alcohol

Answer 8

Facilitates GABA, more inhibitory effects.
Decreases Na+ across membranes- slows down activity
Decreases serotonin activity.
Binging cause neural defense of brain

Question 9

Antipsychotic drugs

Answer 9

Typical neuroleptics- act on DA pathways

Atypical neuroleptics- act on serotonin

Question 10

Antidepressants

Answer 10

MAO- increase monoamine neurotransmitter activity

SSRI-blocks reuptake of serotonin

Question 11

Anti anxiety medication

Answer 11

Barbituates- downers, addictive
Benzodiazepine antagonists- enhance GABA activity
Allopregnanolone - elevated during stress

Question 12

Hallucinogens

Answer 12

Activate serotonin type 2 receptors

Question 13

Caffeine

Answer 13

Antagonist of adenosine.
Adenosine inhibits release of glutamate. Caffeine inhibits the inhibitor.
NOT a stimulant bc it has a different mechanism.