Diagnosis in Endocrine Flashcards
Diagnosis of Addison’s?
on bloods: low Na, high K and hypoglycaemia
Also do SHORT SYNACTHEN test - serum cortisol should rise substantially
Diagnosis of Addison’s?
on bloods: low Na, high K and hypoglycaemia
Also do SHORT SYNACTHEN test - serum cortisol should rise substantially, but in Addison’s disease, it will not
Secondary adrenal insufficiency
SHORT SYNACTHEN, serum cortisol will rise, but steadily instead of substantially
Cushing’s syndrome
Overnight dexamethasone suppresion test
Cortisol and ACTH should decrease due to negative feedback, but in Cushing’s, cortisol will not be decreased
Primary aldosteronism?
confirm aldosterone excess by measuring renin and aldosterone and expressing in in a ratio, if ratio is high then investigate further with a saline suppression test
Confirm subtype with CT scan
Congenital adrenal hyperplasia?
basal progesterone
genetic mutation analysis
Phaeochromocytoma?
Biochem abnormalities: hyperglycaemia, low K level, raised Hb, mild hypocalcaemia, lactic acidosis
Cataclamine excess in urine and plasma
Identify source of cetecholamine excess using MRI scan, MIBG, PET scan
Diagnosis of Hashimotos?
presence of thyroid peroxidase antibodies in blood and T cell infiltrate and inflammation on microscopy
TSH high, T4/3 low
High CK
increased LDL
What happens to prolactin in Hashimoto’s?
increases (increased TRH leads to increased prolactin secretion)
Myxoedema coma?
ECG - bradycardia, heart block, T wave inversion, QT prolongation
Type 2 resp failure: hypoxia, hypercarbia, resp acidosis
Grave’s?
antibody positive (TRAbs) High T3/T4, low TSH Scintigraphy, assymmetrical goitre
Sub acute thyroiditis (De Quervians)?
T4 is high in early stages, low in late, then normal
TSH is low, then high then normal
Thyroid cancer?
ultrasound guided FNA of lesion
Excision biopsy of lymph nodes
(No role for isotope scan or CT/MRI)
Hypercalcaemia?
raised calcium, raised PTH, increased urine calcium excretion
Primary Hyperparathyroidism?
PTH and Ca raised
