Diabetes Pharmacology

Question 1

Acarbose’s MOA?

Answer 1

Blocks enzymes that result in the creation of absorbable monosaccharides

Question 2

Lispro, -Asparts,Detemir, and -degludecs are all _______ _______

Answer 2

Insulin Preparations

Question 3

What cllass of drug is Metformin?

Answer 3

Biguanide

Question 4

Acarbose adverse effects?

Answer 4

Diarrhea

Question 5

Name the main Meglitinide (secretagogue)

Answer 5

Repaglinide

Question 6

The main alpha-glucosidase in hibitor is _____

Answer 6

Acrabose

Question 7

Name the 2 Incretin GLP-1 based therapies

Answer 7

1. Exenatide

2. Liraglutide

Question 8

Name the 2 main sulfonylurea drugs (secretagogues)

Answer 8

1. Glyburide

2. Glipizide

Question 9

Aside from UTIs, Key risk of SGLT2 inhibitors (flozins)?

Answer 9

Diabetic Ketoacidosis

Question 10

Sulfonylureas are Meglitinides are both what kind of drug class?

Answer 10

Secretagogues

Question 11

Insulin lispro, aspart, and glulisine are used when? (think about what acting speed they are)

Answer 11

Right before the meal (rapid)

Question 12

Name the 2 Glitazones

Answer 12

1. Pioglitazone

2. Rosiglitazone

Question 13

What insulin is short-acting?

Answer 13

Regular

Question 14

Linagliptin and Sitagliptin are both ______ ______

Answer 14

DPP-4 Inhibitors

Question 15

How many times should the insulin Detemir be used a day?

Answer 15

Twice (12hr duration)

Question 16

The Glitazones are agonists of _____, that redistributes fat in the body to reduce insulin resistance

Answer 16

PPAR-gamma (peroxisome proliferator-activated receptor-gamma)

Question 17

Exenatide and Liraglutide are both ____ ____ Based Therapy

Answer 17

Incretin GLP-1

Question 18

The insulin Degludec should be used how many times a day?

Answer 18

Once

Question 19

1st line drug for Type 2 diabetes is _____ which lowers glucose to Euglycemic levels and is well tolerated

Answer 19

Metformin

Question 20

Canagliflozin and Dapagliflozin are both ______ ______

Answer 20

SGLT2 Inhibitors

Question 21

Lispro and -asparts are both _____-acting Insulin preparations

Answer 21

Rapid

Question 22

Regular insulin is _____-acting.

Answer 22

Short

Question 23

Short-acting insulin has effects that appear within how long? _____

Answer 23

30 minutes

Question 24

Name the 2 Rapid-acting Insulin preparations

Answer 24

1. Lispro

2. -Asparts

Question 25

Insulin Secreatogogue drugs MOA

Answer 25

Blocks pancreatic K+ channel, resulting in easier depolarization to create insulin

Question 26

4 Risks of Glitazones that use PPAR-gamma

Answer 26

1. Weight gain
2. Edema
3. HDL/LDL changes
4. BIG Liver problems

Question 27

Name the 2 DPP-4 Inhibitors

Answer 27

1. Linagliptin

2. Sitagliptin

Question 28

Name the “Big Metaphysical” Biguanide drug name

Answer 28

Metformin

Question 29

Name the 2 SGLT2 inhibitors that promote “flow”

Answer 29

1. Canagliflozin

2. Dapagliflozin

Question 30

Glyburide and Glipizide are both _____ drugs of the general class; (______)

Answer 30

• Sulfonylureas (secretagogues)

Question 31

Exenatide and Liraglutide are both _____

Answer 31

GLP-1 Receptor Agonists

Question 32

When should meglitinides such as Repaglinide be used?

Answer 32

Just BEFORE a meal

Question 33

Name the 2 Long-acting insulin preparations

Answer 33

1. Detemir

2. -Degludecs

Question 34

Detemir and -degludec are both _____-acting insulin preparations

Answer 34

Long

Question 35

Repaglinide is the main ______ of the class of drug (_____)

Answer 35

• Meglitinides (secretagogues)

Question 36

Acarbose is a _____ _____

Answer 36

Alpha-glucosidase inhibitor