Chemotherapy Drugs

Question 1

Name the drug class that is a G-Phase DNA damage disruptors

Answer 1

DNA Intercalating Agents

Question 2

Aside from hemorrhagic skin cystitis, What additional specific risk does cyclophosphamide pose?

Answer 2

CANCER (acute myelogenous leukemia)

Question 3

Name the 2 drug classes that disrupt mitotic spindles

Answer 3

1. Taxanes

2. Vinca Alkaloids

Question 4

Name the 4 Drug classes that disrupt S phase

Answer 4

1. Purine/Pyrimid Analogs
2. Antimetabolites
3. Antifolates
4. Epipodophyllotoxins

Question 5

When taking the deoxycytidine analog, Gemcitabine, watch out for ______ _____ Syndrome as a toxicity!

Answer 5

Hemolytic Uremic

Question 6

Vinca alkaloids (vincristine) and Taxanes (paclitaxel) are both ______ _____

Answer 6

Microtubule disruptors

Question 7

If a person has kidney disease, you would want to avoid the alkylating agent, _______ and instead use ______

Answer 7

Cisplatin, Carboplatin

Question 8

What is they key highlighted Pyridine analog of Deoxyctidine that is used to treat cancer?

Answer 8

Gemcitabine

Question 9

Gemcitabine is a ______ ____ drug

Answer 9

Deoxycytidine Analog

Question 10

The epipodophyllotoxins (Etoposide), Capothecin (Irinotecan), and Anthracylcin (Doxonrubicin) all inhibit the enzyme ______

Answer 10

Topoisomerase

Question 11

The MT disuptors Vin and Pac 3 key toxicities

Answer 11

• Neurotox
• ANS dysfxn
• SIADH

Question 12

Considering the indication of Alkylating Agents, what are their 3 overall sideffects?

Answer 12

1. GI problems
2. Bone Marrow Depression (low immune cells)
3. Reproductive system probs

Question 13

Both of the Antifolate drugs, Pemetrexed and 5-FU target the enzyme _____(___) to reduce DHFR to lessen DNA & RNA biosynthesis

Answer 13

Thymidylate Synthase (TS)

Question 14

The alkylating drug Cisplatin treats what types of cancer?

Answer 14

Basically all of them

Non-small and small, head, neck, lung, and GI

Question 15

The deoxycytidine analog, Gemcitabine inhibits which two enzymes?

Answer 15

1. Ribonucleatide Reductase

2. DNA polymerase

Question 16

Aside from nephrotoxicity and ototoxicity, what major and speific toxicity occurs with Cisplatin?

Answer 16

Irreversible Nerve Dysfunction

Question 17

Name the 3 Topoisomerase inhibitors

Answer 17

1. Etoposide
2. Irinotecan
3. Doxorubicin

Question 18

Etoposide, Irinotecan, and Doxorubicin are all _____ inhibitors

Answer 18

Topoisomerase

Question 19

In order to become a Pur/Pyr, Folate become Dihydrofolate, then Tetrahydrofolate via the enzyme ______

Answer 19

DiHydrofolate Reductase (DHFR)

Question 20

Considering that Irinotecan the Topo 1 inhibitor treats colorectal cancer, the most common toxicity is ______

Answer 20

Diarrhea

Question 21

Vincristine and Paclitaxel are both MT disruptors disrupting mitosis, however Vin ____ polymerization, whereas Pac _____ polymerization

Answer 21

• Vin inhibits

- Pac promotes

Question 22

Aside from myelosuppression and GI problems, the Anthracyclin, Doxorubicin’s MAJOR SEVERE toxicity is ______

Answer 22

CARDIOTOXICITY

2-3 days watch for arrhythmias

Question 23

Purine/Pyrimidine analogs, antimetabolites, antifolates, and Epipodophyllo toxins all block the ____ phase of the cell cycle.

Answer 23

S

Question 24

Pemetrexed and 5-Fluorouracil are both ______ Cancer Drugs

Answer 24

Anti-Folate

Question 25

Carboplatin vs Cisplatin

Answer 25

Carbo is better for the kidneys!

Question 26

Out of the topoisomerase cancer drugs, why is Irinotecan different?

Answer 26

It targets Topoisomerase 1

- Etoposide and Doxorubicin target Topo 2

Question 27

What is the indication for Alkylating Agents?

Answer 27

Treating Rapidly dividing cancers

Question 28

Name the 3 highlighted Alkylating drugs

Answer 28

1. Cyclophasphamide
2. Cisplatin
3. Carboplatin

Question 29

Name the 2 highlighted Antifolate cancer drugs

Answer 29

1. Pemetrexed

2. 5-Fluorouracil

Question 30

Vin is used for _____ malignancies

Answer 30

Hematologic

Question 31

The deoxycytidine analog, Gemcitabine treat NSCLC as well as _____ Cancer

Answer 31

Pancreatic

Question 32

Aside from myelosuppresion, 2 key Toxicities of Etoposide, the Topo 2 inhibitor

Answer 32

1. Hypotension

2. Alopecia

Question 33

Cyclophasphamide, Cisplatin, and Carboplatin are all _____ Drugs

Answer 33

Alkylating

Question 34

Pac is used for _____ malignancies

Answer 34

Solid

Question 35

Irinotecan the Topo 1 inhibitor specifically treats _____ cancer

Answer 35

Colorectal

Question 36

DO NOT USE 5-FU IF THE PATIENT HAS LOW LEVELS OF _____(_____)

Answer 36

Dihydropuridine Dehydrogenase (DPD)

Question 37

What happens with cyclophosphamide and the liver?

Answer 37

The Liver activates cyclophosphamide

Question 38

Aside from Gi probs, neurotoxicity, and myelosuppression, what characteristic toxicity finding indicates the use of an Antifolate drug such as Pemetrexed or 5-FU?

Answer 38

HAND-FOOT SYNDROME

Question 39

The alkylating drug Cyclophosphamide specifically treats:

Answer 39

Breast and Ovarian Cancers

Question 40

Alkylating Agents and DNA intercalating agents block the _____ phase of the cell cycle.

Answer 40

G

Question 41

The anthracyclin Doxorubicin, is an Anti-tumor antibiotic that specifically treats _____ _____

Answer 41

Hodgkins Lymphoma

Question 42

Antifolate drugs Pemetrexed and 5-Fluorouracil are only used for _____

Answer 42

NSCLC (adenocarcinoma in the lung)