Anxiolytic/Sedative/Hypnotics Flashcards
Non-GABAergic hypnotics two potential MOA
Melatonin or Orexin
In terms of treating Anxiety, Busprione has less adverse effects compared to Benzos or SSRIs, so why isn’t it used for GAD?
Inconsistent efficacy
Benzos general MOA:
GABA-ergic by promoting frequency of Cl- Channel opening
Antihistamines and antipsychotics both anti______ergic effects, whereas TCAs don’t.
Dopamin
Quetiapine is an atypical antipsychotic that help anxiety by antagonizing _______ receptor
Serotonin2A
3 memorable Non-Benzo Hypnotics
- Zolpidem
- Zaleplon
- Eszopiclone
“Catch those Z’s”
What is Flumazenils therapeutic function?
Treat Benzo overdose
Zolpidem, Zaleplon, Eszopiclone are all ____ hypnotics that bind to GABAa receptor specically only ones with Alpha1 subunits
Non-Benzo
Suvorexant is a Non-GABAergic hypnotic whose MOA is:
Antagonize Orexin Receptors
Hydroxyzine is an anti-histamine that also antagonizing the _______ receptor
Serotonin2A
Name the 2 Non-GABAergic hypnotics agonizes Melatonin Receptors
- Ramelteon
- Tasimelteon
“These guys make you melt from mucho melatonin”
Pregabalin increases presynaptic release of _______, by binding to a sodium channel.
GABA
For SSRI’s, they promote which serotonin receptor and downreg which serotonin receptor to have a double anxiety calming effect?
- Promote 5-HT1A
- Downreg 5-HT2A/C
Adminster ______ to treat Benzo overdose
Flumazenil
Midazolam is among the drug class ______ with what Pharmacokinetic property which makes it ideal to sedate before surgery?
- Benzodiazepines
- Shortest half-life
“outta your system Mida Quick”
