Anti-psychotic Drugs

Question 1

Despite the risk of agranulocytosis, why does Clozapine present with less extrapyramidal effects (bradykinesia, rigidity, termors)?

Answer 1

Because it barely blocks D2

Question 2

Typical antipsychotic MOA

Answer 2

D2 Receptor Antagonist

Question 3

Clozapine, Olanzapine, Quetiapine, Risperidone, Ziprasidone, Aripiprazole are all what class of drugs?

Answer 3

Atypical Antipsychotics

Question 4

What is surprising of Aripiprazole’s mechanism of action?

Answer 4

PARTIAL AGONIST at D2

lowers, but doesn’t eliminate DA activity

Question 5

Atypical antipsychotic MOA

Answer 5

• Weak D2 antagonist

- Moderate 5HT2 receptor antagonists (less negative symptoms)

Question 6

Name 6 Atypical antipsychotics

Answer 6

1. Clozapine
2. Olanzapine
3. Quetiapine
4. Risperidone
5. Ziprasidone
6. Aripiprazole

Question 7

Typical antipsychotics have which 2 classes of side-effects? Especially Thioridazine

Answer 7

1. Anti-Dopaminergic

2. Anti-adrenergic

Question 8

Name 4 Typical Antipsychotics

Answer 8

1. Chlorpromazine
2. Phenothiazine
3. Haloperidol
4. Thioridazine

Question 9

Chlorpromazine, Phenothiazine, Haloperidol, Thioridazine are all what class of drugs?

Answer 9

Typical Antipsychotics